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Guidelines

MIRAGE

solute carrier family 5 (sodium/glucose cotransporter), member 2

Summary

Gene Symbol

Slc5a2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

246787

KEGG Gene ID

PubChem

246787

Alliance of Genome Resources

MGI:2181411

Annotation

Keyword

Cell membrane
Disulfide bond
Glycoprotein
Metal-binding
Reference proteome
Sodium transport
Sugar transport
Symport
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q923I7	Low affinity sodium-glucose cotransporter Solute carrier family 5 member 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
alpha-glucoside transport	ISO
alpha-glucoside transport	IEA
renal system process	IEA
sodium ion transport
renal D-glucose absorption	IMP

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

hexose import across plasma membrane [inference]

D-glucose import across plasma membrane

D-glucose transmembrane transport

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

D-glucose import across plasma membrane

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

import across plasma membrane [inference]

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

D-glucose import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

multicellular organismal process [inference]

system process [inference]

renal system process

regulation of urine volume [inference]

negative regulation of urine volume

renal absorption [inference]

renal D-glucose absorption

renal tubular secretion [inference]

renal potassium excretion

excretion [inference]

renal tubular secretion [inference]

renal potassium excretion

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

carbohydrate transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

hexose import across plasma membrane [inference]

D-glucose import across plasma membrane

D-glucose transmembrane transport

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

D-glucose import across plasma membrane

transmembrane transport

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

hexose import across plasma membrane [inference]

D-glucose import across plasma membrane

D-glucose transmembrane transport

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

D-glucose import across plasma membrane

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

import across plasma membrane [inference]

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

D-glucose import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

import into cell [inference]

import across plasma membrane [inference]

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

D-glucose import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

carbohydrate derivative transport [inference]

glycoside transport [inference]

glucoside transport [inference]

alpha-glucoside transport

biological regulation [inference]

regulation of biological quality [inference]

regulation of body fluid levels [inference]

regulation of urine volume [inference]

negative regulation of urine volume

Displaying entries **6 - 8** of 8 in total

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GO Term	Evidence Code	PMID
apical plasma membrane	IEA
brush border membrane	ISO
transmembrane transporter complex	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

transmembrane transporter complex

transporter complex [inference]

transmembrane transporter complex

cellular anatomical structure [inference]

plasma membrane

plasma membrane region [inference]

apical plasma membrane

cell projection membrane [inference]

brush border membrane

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
D-glucose:sodium symporter activity	ISS
D-glucose:sodium symporter activity	ISO
D-glucose:sodium symporter activity	IBA
D-glucose:sodium symporter activity	IEA
protein binding	IPI

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

carbohydrate:monoatomic cation symporter activity [inference]

D-glucose:sodium symporter activity

solute:sodium symporter activity [inference]

D-glucose:sodium symporter activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

D-glucose:sodium symporter activity

carbohydrate transmembrane transporter activity [inference]

carbohydrate:monoatomic cation symporter activity [inference]

D-glucose:sodium symporter activity

sugar transmembrane transporter activity [inference]

monosaccharide transmembrane transporter activity [inference]

hexose transmembrane transporter activity [inference]

D-glucose transmembrane transporter activity

D-glucose:sodium symporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity [inference]

solute:monoatomic cation symporter activity [inference]

carbohydrate:monoatomic cation symporter activity [inference]

D-glucose:sodium symporter activity

solute:sodium symporter activity [inference]

D-glucose:sodium symporter activity

carbohydrate derivative transmembrane transporter activity [inference]

glucoside transmembrane transporter activity [inference]

alpha-glucoside transmembrane transporter activity

binding [inference]

protein binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

solute carrier family 5 member 5

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
Sodium/glucose symporter superfamily
Sodium/solute symporter

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources
Rattus norvegicus	64522	RGD:620217
Homo sapiens	6524	HGNC:11037

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026