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Guidelines

MIRAGE

renin

Summary

Gene Symbol

Ren

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

24715

PubChem

24715

Alliance of Genome Resources

RGD:3554

Annotation

Keyword

3D-structure
Aspartyl protease
Cleavage on pair of basic residues
Disulfide bond
Glycoprotein
Membrane
Reference proteome
Secreted
Signal
Zymogen

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P08424	Angiotensinogenase
A6IC75	Angiotensinogenase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 27 in total

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GO Term	Evidence Code	PMID
kidney development	ISO
mesonephros development	ISO
angiotensin maturation	ISO
angiotensin maturation	IDA	21321306
angiotensin maturation	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing [inference]

angiotensin maturation

amyloid-beta metabolic process

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing [inference]

angiotensin maturation

amyloid-beta metabolic process

protein metabolic process [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

hormone metabolic process [inference]

peptide hormone processing [inference]

angiotensin maturation

primary metabolic process [inference]

protein metabolic process [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing [inference]

angiotensin maturation

amyloid-beta metabolic process

protein metabolic process [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

cellular process [inference]

signal transduction [inference]

hormone-mediated signaling pathway

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

endothelial cell development [inference]

establishment of blood-nerve barrier

cell maturation

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to xenobiotic stimulus

reproductive process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

male gonad development

multicellular organismal process [inference]

system process [inference]

renal system process [inference]

renal system process involved in regulation of systemic arterial blood pressure [inference]

renin-angiotensin regulation of aldosterone production

endocrine process [inference]

regulation of systemic arterial blood pressure by hormone [inference]

regulation of systemic arterial blood pressure by renin-angiotensin [inference]

regulation of blood volume by renin-angiotensin

behavior [inference]

feeding behavior [inference]

drinking behavior

developmental process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

male gonad development

developmental maturation [inference]

anatomical structure maturation [inference]

cell maturation

anatomical structure development [inference]

cell development [inference]

epithelial cell development [inference]

endothelial cell development [inference]

establishment of blood-nerve barrier

animal organ development [inference]

kidney development

mesonephros development

gonad development [inference]

male gonad development

reproductive structure development [inference]

gonad development [inference]

male gonad development

juxtaglomerular apparatus development

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

endothelial cell development [inference]

establishment of blood-nerve barrier

cell maturation

response to stimulus [inference]

response to stress [inference]

response to immobilization stress

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to chemical [inference]

response to xenobiotic stimulus

cellular response to xenobiotic stimulus

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to organic cyclic compound [inference]

response to purine-containing compound [inference]

response to lipid [inference]

response to lipopolysaccharide

response to organophosphorus [inference]

cellular response to chemical stimulus [inference]

cellular response to xenobiotic stimulus

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to oxygen-containing compound [inference]

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to xenobiotic stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade

regulation of hormone secretion [inference]

regulation of steroid hormone secretion [inference]

regulation of corticosteroid hormone secretion [inference]

regulation of mineralocorticoid secretion [inference]

regulation of aldosterone secretion [inference]

renin-angiotensin regulation of aldosterone production

regulation of localization [inference]

regulation of transport [inference]

regulation of lipid transport [inference]

regulation of steroid hormone secretion [inference]

regulation of corticosteroid hormone secretion [inference]

regulation of mineralocorticoid secretion [inference]

regulation of aldosterone secretion [inference]

renin-angiotensin regulation of aldosterone production

regulation of secretion [inference]

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

regulation of steroid hormone secretion [inference]

regulation of corticosteroid hormone secretion [inference]

regulation of mineralocorticoid secretion [inference]

regulation of aldosterone secretion [inference]

renin-angiotensin regulation of aldosterone production

regulation of lipid localization [inference]

regulation of lipid transport [inference]

regulation of steroid hormone secretion [inference]

regulation of corticosteroid hormone secretion [inference]

regulation of mineralocorticoid secretion [inference]

regulation of aldosterone secretion [inference]

renin-angiotensin regulation of aldosterone production

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade

regulation of cellular process [inference]

signal transduction [inference]

hormone-mediated signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade

regulation of hormone secretion [inference]

regulation of steroid hormone secretion [inference]

regulation of corticosteroid hormone secretion [inference]

regulation of mineralocorticoid secretion [inference]

regulation of aldosterone secretion [inference]

renin-angiotensin regulation of aldosterone production

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

regulation of steroid hormone secretion [inference]

regulation of corticosteroid hormone secretion [inference]

regulation of mineralocorticoid secretion [inference]

regulation of aldosterone secretion [inference]

renin-angiotensin regulation of aldosterone production

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of endocrine process [inference]

regulation of steroid hormone secretion [inference]

regulation of corticosteroid hormone secretion [inference]

regulation of mineralocorticoid secretion [inference]

regulation of aldosterone secretion [inference]

renin-angiotensin regulation of aldosterone production

regulation of biological quality [inference]

regulation of blood pressure

regulation of systemic arterial blood pressure [inference]

regulation of systemic arterial blood pressure mediated by a chemical signal [inference]

regulation of systemic arterial blood pressure by hormone [inference]

regulation of systemic arterial blood pressure by renin-angiotensin [inference]

regulation of blood volume by renin-angiotensin

regulation of hormone levels [inference]

hormone metabolic process [inference]

peptide hormone processing [inference]

angiotensin maturation

regulation of hormone secretion [inference]

regulation of steroid hormone secretion [inference]

regulation of corticosteroid hormone secretion [inference]

regulation of mineralocorticoid secretion [inference]

regulation of aldosterone secretion [inference]

renin-angiotensin regulation of aldosterone production

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
extracellular region	ISO
extracellular space	ISO
extracellular space	IDA	1278112
extracellular space	IBA
extracellular space	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
endopeptidase activity	ISO
endopeptidase activity	IDA	7060565
aspartic-type endopeptidase activity	ISO
aspartic-type endopeptidase activity	IBA
aspartic-type endopeptidase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity

aspartic-type endopeptidase activity

aspartic-type peptidase activity [inference]

aspartic-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity

aspartic-type endopeptidase activity

aspartic-type peptidase activity [inference]

aspartic-type endopeptidase activity

binding [inference]

protein binding [inference]

signaling receptor binding

insulin-like growth factor receptor binding

Gene Ontology information from NCBI Gene and UniProt.

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
extracellular space	PMID:1278112

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:10763	hypertension	Alliance of Genome Resources

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Last updated: April 6, 2026