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adrenoceptor beta 1

Summary

Gene Symbol

Adrb1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

24925

PubChem

24925

Alliance of Genome Resources

RGD:2059

Annotation

Keyword

Cell membrane
Disulfide bond
Endosome
G-protein coupled receptor
Glycoprotein
Palmitate
Phosphoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P18090	Beta-1 adrenoreceptor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 53 in total

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GO Term	Evidence Code	PMID
diet induced thermogenesis	IEA
norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	ISO
norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IBA
norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IEA
positive regulation of the force of heart contraction by norepinephrine	IDA	19133992

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

carbohydrate catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

energy reserve metabolic process [inference]

glycogen metabolic process [inference]

glycogen catabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

glucan metabolic process [inference]

glycogen metabolic process [inference]

glycogen catabolic process

glucan catabolic process [inference]

glycogen catabolic process

carbohydrate catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

glucan metabolic process [inference]

glycogen metabolic process [inference]

glycogen catabolic process

glucan catabolic process [inference]

glycogen catabolic process

carbohydrate catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

macromolecule metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

glucan metabolic process [inference]

glycogen metabolic process [inference]

glycogen catabolic process

glucan catabolic process [inference]

glycogen catabolic process

macromolecule catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

carbohydrate catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

adaptive thermogenesis [inference]

diet induced thermogenesis

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

adenylate cyclase-activating adrenergic receptor signaling pathway

adrenergic receptor signaling pathway [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rho protein signal transduction

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

energy reserve metabolic process [inference]

glycogen metabolic process [inference]

glycogen catabolic process

cellular developmental process [inference]

cell differentiation [inference]

fat cell differentiation [inference]

brown fat cell differentiation

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

vasodilation [inference]

norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure

renal system process [inference]

regulation of urine volume [inference]

negative regulation of urine volume

nervous system process [inference]

cognition [inference]

learning or memory [inference]

memory

behavior [inference]

learning or memory [inference]

memory

multicellular organismal response to stress [inference]

fear response

multicellular organismal-level homeostasis [inference]

temperature homeostasis [inference]

heat generation

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

fat cell differentiation [inference]

brown fat cell differentiation

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

temperature homeostasis [inference]

heat generation

chemical homeostasis [inference]

lipid homeostasis

response to stimulus [inference]

response to stress [inference]

response to cold

multicellular organismal response to stress [inference]

fear response

response to abiotic stimulus [inference]

response to temperature stimulus [inference]

response to cold

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of synaptic transmission [inference]

positive regulation of long-term synaptic potentiation

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

regulation of long-term synaptic potentiation [inference]

positive regulation of long-term synaptic potentiation

positive regulation of synaptic transmission [inference]

positive regulation of long-term synaptic potentiation

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of cation channel activity

regulation of cation channel activity [inference]

positive regulation of cation channel activity

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of cation channel activity

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion import across plasma membrane

positive regulation of cation channel activity

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of cation channel activity

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion import across plasma membrane

positive regulation of cation channel activity

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion import across plasma membrane

regulation of calcium ion import across plasma membrane [inference]

positive regulation of calcium ion import across plasma membrane

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion import across plasma membrane

positive regulation of cation channel activity

regulation of cation channel activity [inference]

positive regulation of cation channel activity

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of calcium ion transport

positive regulation of calcium ion transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion import across plasma membrane

regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion import across plasma membrane

regulation of calcium ion import across plasma membrane [inference]

positive regulation of calcium ion import across plasma membrane

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of cation channel activity

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion import across plasma membrane

positive regulation of cation channel activity

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion import across plasma membrane

regulation of calcium ion import across plasma membrane [inference]

positive regulation of calcium ion import across plasma membrane

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion import across plasma membrane

positive regulation of cation channel activity

regulation of cation channel activity [inference]

positive regulation of cation channel activity

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of cation channel activity

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion import across plasma membrane

positive regulation of cation channel activity

positive regulation of calcium ion transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion import across plasma membrane

positive regulation of transport [inference]

positive regulation of transporter activity [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of cation channel activity

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of cation channel activity

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion import across plasma membrane

positive regulation of cation channel activity

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of cation channel activity

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion import across plasma membrane

positive regulation of cation channel activity

positive regulation of calcium ion transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion import across plasma membrane

regulation of growth [inference]

regulation of cell growth [inference]

positive regulation of cell growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of cell growth involved in cardiac muscle cell development [inference]

positive regulation of cell growth involved in cardiac muscle cell development

negative regulation of growth [inference]

negative regulation of developmental growth [inference]

negative regulation of multicellular organism growth

positive regulation of growth [inference]

positive regulation of cell growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of developmental growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of developmental growth [inference]

regulation of multicellular organism growth [inference]

negative regulation of multicellular organism growth

regulation of organ growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of heart growth [inference]

regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of cell growth involved in cardiac muscle cell development [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of developmental growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

negative regulation of developmental growth [inference]

negative regulation of multicellular organism growth

regulation of circadian rhythm [inference]

regulation of circadian sleep/wake cycle [inference]

regulation of circadian sleep/wake cycle, sleep

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of cold-induced thermogenesis

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of synaptic transmission [inference]

positive regulation of long-term synaptic potentiation

positive regulation of growth [inference]

positive regulation of cell growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of developmental growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of synaptic transmission [inference]

positive regulation of long-term synaptic potentiation

positive regulation of cell growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of cation channel activity

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion import across plasma membrane

positive regulation of cation channel activity

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of transport [inference]

positive regulation of transporter activity [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of cation channel activity

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of cation channel activity

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion import across plasma membrane

positive regulation of cation channel activity

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of cation channel activity

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion import across plasma membrane

positive regulation of cation channel activity

positive regulation of calcium ion transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion import across plasma membrane

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of developmental growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of multicellular organismal process [inference]

positive regulation of muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of cold-induced thermogenesis

positive regulation of blood circulation [inference]

positive regulation of heart contraction [inference]

positive regulation of the force of heart contraction by chemical signal [inference]

positive regulation of heart rate

positive regulation of heart rate by epinephrine-norepinephrine

negative regulation of biological process [inference]

negative regulation of growth [inference]

negative regulation of developmental growth [inference]

negative regulation of multicellular organism growth

negative regulation of developmental process [inference]

negative regulation of developmental growth [inference]

negative regulation of multicellular organism growth

negative regulation of multicellular organismal process [inference]

negative regulation of multicellular organism growth

negative regulation of muscle contraction [inference]

negative regulation of smooth muscle contraction

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of muscle adaptation [inference]

regulation of cardiac muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of muscle cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of striated muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of developmental growth [inference]

regulation of multicellular organism growth [inference]

negative regulation of multicellular organism growth

regulation of organ growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of heart growth [inference]

regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of cell growth involved in cardiac muscle cell development [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of developmental growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

negative regulation of developmental growth [inference]

negative regulation of multicellular organism growth

negative regulation of developmental process [inference]

negative regulation of developmental growth [inference]

negative regulation of multicellular organism growth

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of developmental growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of multicellular organismal development [inference]

regulation of heart growth [inference]

regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of cell growth involved in cardiac muscle cell development [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

adenylate cyclase-activating adrenergic receptor signaling pathway

adrenergic receptor signaling pathway [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rho protein signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of synaptic transmission [inference]

positive regulation of long-term synaptic potentiation

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

regulation of long-term synaptic potentiation [inference]

positive regulation of long-term synaptic potentiation

positive regulation of synaptic transmission [inference]

positive regulation of long-term synaptic potentiation

regulation of actin filament-based process [inference]

regulation of actin filament-based movement [inference]

regulation of cardiac muscle cell contraction

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of cation channel activity

regulation of cation channel activity [inference]

positive regulation of cation channel activity

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of cation channel activity

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion import across plasma membrane

positive regulation of cation channel activity

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of cation channel activity

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion import across plasma membrane

positive regulation of cation channel activity

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion import across plasma membrane

regulation of calcium ion import across plasma membrane [inference]

positive regulation of calcium ion import across plasma membrane

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion import across plasma membrane

positive regulation of cation channel activity

regulation of cation channel activity [inference]

positive regulation of cation channel activity

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of muscle cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of striated muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of synaptic transmission [inference]

positive regulation of long-term synaptic potentiation

positive regulation of cell growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of cation channel activity

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of calcium ion import across plasma membrane

positive regulation of cation channel activity

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of cellular component organization [inference]

regulation of cell growth [inference]

positive regulation of cell growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of cell growth involved in cardiac muscle cell development [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of multicellular organismal process [inference]

regulation of multicellular organism growth [inference]

negative regulation of multicellular organism growth

regulation of system process [inference]

regulation of muscle system process [inference]

regulation of muscle contraction [inference]

regulation of smooth muscle contraction [inference]

negative regulation of smooth muscle contraction

regulation of striated muscle contraction [inference]

regulation of cardiac muscle contraction [inference]

regulation of cardiac muscle cell contraction

negative regulation of muscle contraction [inference]

negative regulation of smooth muscle contraction

regulation of muscle hypertrophy [inference]

regulation of cardiac muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of muscle adaptation [inference]

regulation of cardiac muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of blood circulation [inference]

regulation of heart contraction [inference]

regulation of the force of heart contraction [inference]

regulation of the force of heart contraction by chemical signal [inference]

positive regulation of the force of heart contraction by chemical signal [inference]

regulation of heart rate [inference]

positive regulation of heart rate

positive regulation of heart rate by epinephrine-norepinephrine

positive regulation of heart contraction [inference]

positive regulation of the force of heart contraction by chemical signal [inference]

positive regulation of heart rate

positive regulation of heart rate by epinephrine-norepinephrine

regulation of cardiac muscle contraction [inference]

regulation of cardiac muscle cell contraction

positive regulation of blood circulation [inference]

positive regulation of heart contraction [inference]

positive regulation of the force of heart contraction by chemical signal [inference]

positive regulation of heart rate

positive regulation of heart rate by epinephrine-norepinephrine

regulation of organ growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of heart growth [inference]

regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of cell growth involved in cardiac muscle cell development [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of behavior [inference]

regulation of circadian sleep/wake cycle [inference]

regulation of circadian sleep/wake cycle, sleep

positive regulation of multicellular organismal process [inference]

positive regulation of muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of cold-induced thermogenesis

positive regulation of blood circulation [inference]

positive regulation of heart contraction [inference]

positive regulation of the force of heart contraction by chemical signal [inference]

positive regulation of heart rate

positive regulation of heart rate by epinephrine-norepinephrine

negative regulation of multicellular organismal process [inference]

negative regulation of multicellular organism growth

negative regulation of muscle contraction [inference]

negative regulation of smooth muscle contraction

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

regulation of multicellular organismal development [inference]

regulation of heart growth [inference]

regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of cell growth involved in cardiac muscle cell development [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of biological quality [inference]

regulation of the force of heart contraction [inference]

regulation of the force of heart contraction by chemical signal [inference]

positive regulation of the force of heart contraction by chemical signal [inference]

regulation of heart rate [inference]

positive regulation of heart rate

positive regulation of heart rate by epinephrine-norepinephrine

regulation of blood pressure [inference]

negative regulation of blood pressure [inference]

negative regulation of systemic arterial blood pressure [inference]

norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure

positive regulation of blood pressure [inference]

positive regulation of systemic arterial blood pressure

regulation of membrane potential [inference]

regulation of postsynaptic membrane potential

inhibitory postsynaptic potential

regulation of synaptic plasticity [inference]

regulation of long-term synaptic potentiation [inference]

positive regulation of long-term synaptic potentiation

regulation of body fluid levels [inference]

regulation of urine volume [inference]

negative regulation of urine volume

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

vasodilation [inference]

norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure

regulation of molecular function [inference]

regulation of transporter activity [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of cation channel activity

regulation of cation channel activity [inference]

positive regulation of cation channel activity

positive regulation of transporter activity [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of cation channel activity

positive regulation of molecular function [inference]

positive regulation of transporter activity [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of cation channel activity

positive regulation of catalytic activity [inference]

positive regulation of cyclase activity [inference]

positive regulation of adenylate cyclase activity

positive regulation of lyase activity [inference]

positive regulation of adenylate cyclase activity

regulation of catalytic activity [inference]

regulation of cyclase activity [inference]

positive regulation of cyclase activity [inference]

positive regulation of adenylate cyclase activity

regulation of adenylate cyclase activity [inference]

positive regulation of adenylate cyclase activity

positive regulation of catalytic activity [inference]

positive regulation of cyclase activity [inference]

positive regulation of adenylate cyclase activity

positive regulation of lyase activity [inference]

positive regulation of adenylate cyclase activity

regulation of lyase activity [inference]

regulation of adenylate cyclase activity [inference]

positive regulation of adenylate cyclase activity

positive regulation of lyase activity [inference]

positive regulation of adenylate cyclase activity

Displaying entries **11 - 13** of 13 in total

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GO Term	Evidence Code	PMID
postsynapse	IEA
neuronal dense core vesicle	ISO
neuronal dense core vesicle	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

cell junction [inference]

synapse [inference]

Schaffer collateral - CA1 synapse

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

secretory vesicle [inference]

secretory granule [inference]

dense core granule [inference]

neuronal dense core vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

secretory vesicle [inference]

secretory granule [inference]

dense core granule [inference]

neuronal dense core vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

secretory vesicle [inference]

secretory granule [inference]

dense core granule [inference]

neuronal dense core vesicle

postsynapse

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
beta1-adrenergic receptor activity	ISS
beta1-adrenergic receptor activity	ISO
beta1-adrenergic receptor activity	IDA	12514203
beta1-adrenergic receptor activity	IBA
beta1-adrenergic receptor activity	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

G protein-coupled receptor binding [inference]

adrenergic receptor binding [inference]

alpha-2A adrenergic receptor binding

protein domain specific binding [inference]

PDZ domain binding

protein dimerization activity [inference]

protein heterodimerization activity

amine binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled amine receptor activity [inference]

adrenergic receptor activity [inference]

beta-adrenergic receptor activity [inference]

beta1-adrenergic receptor activity

G protein-coupled neurotransmitter receptor activity [inference]

G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential

G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential [inference]

G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential

neurotransmitter receptor activity [inference]

postsynaptic neurotransmitter receptor activity [inference]

neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential [inference]

G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential

G protein-coupled neurotransmitter receptor activity [inference]

G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Alpha-2B adrenergic receptor

Functional Category

O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
adenylate cyclase-activating adrenergic receptor signaling pathway
adrenergic receptor activity
adrenergic receptor signaling pathway
alpha2-adrenergic receptor activity
epinephrine binding

Displaying **all 3** entries
InterPro
Adrenoceptor family
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:12930	dilated cardiomyopathy	Alliance of Genome Resources
DOID:1591	renovascular hypertension	Alliance of Genome Resources
DOID:5844	myocardial infarction	Alliance of Genome Resources
DOID:6000	congestive heart failure	Alliance of Genome Resources
DOID:824	periodontitis	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 49 in total

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Species	Gene ID	Orthologous MAtrix
Chrysemys picta bellii	101935916	CHRPI36350
Capra hircus	102187558	CAPHI17671
Latimeria chalumnae	102359969	LATCH08753
Callorhinchus milii	103186583	CALMI34946
Chlorocebus sabaeus	103216543	CHLSB18128
Macaca nemestrina	105467024	MACNE27497
Cercocebus atys	105577918	CERAT13219
Macaca fascicularis	107126443	MACFA43439
Sinocyclocheilus grahami	107566002	SINGR20499
Sinocyclocheilus grahami	107581665	SINGR07355

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements