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TNF receptor superfamily member 8

Summary

Gene Symbol

Tnfrsf8

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

25069

KEGG Gene ID

PubChem

25069

Alliance of Genome Resources

RGD:3879

Annotation

Keyword

Cell membrane
Disulfide bond
Glycoprotein
Phosphoprotein
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying **all 4** entries
UniProt	Protein Name
F1LNN5
A6IU17
A6IU18
P97525	CD30L receptor Lymphocyte activation antigen CD30

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
signal transduction	IEA
positive regulation of TRAIL production	ISO
positive regulation of tumor necrosis factor production	ISO
positive regulation of apoptotic process	ISO
cellular response to mechanical stimulus	ISO

GO Hierarchy

biological process

cellular process [inference]

signal transduction

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

response to stimulus [inference]

response to external stimulus [inference]

response to mechanical stimulus [inference]

cellular response to mechanical stimulus

cellular response to external stimulus [inference]

cellular response to mechanical stimulus

response to abiotic stimulus [inference]

response to mechanical stimulus [inference]

cellular response to mechanical stimulus

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

regulation of cellular process [inference]

signal transduction

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

regulation of tumor necrosis factor superfamily cytokine production [inference]

regulation of TRAIL production [inference]

positive regulation of TRAIL production

regulation of tumor necrosis factor production [inference]

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

regulation of tumor necrosis factor superfamily cytokine production [inference]

regulation of TRAIL production [inference]

positive regulation of TRAIL production

regulation of tumor necrosis factor production [inference]

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

regulation of tumor necrosis factor superfamily cytokine production [inference]

regulation of TRAIL production [inference]

positive regulation of TRAIL production

regulation of tumor necrosis factor production [inference]

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

Displaying **all 4** entries
GO Term	Evidence Code	PMID
nucleoplasm
plasma membrane	ISS
plasma membrane	ISO
plasma membrane	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

nucleoplasm

membrane [inference]

plasma membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protease binding	ISO
transmembrane signaling receptor activity	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

enzyme binding [inference]

protease binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity

Gene Ontology information from NCBI Gene and UniProt.

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	21941	MGI:99908
Homo sapiens	943	HGNC:11923

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Last updated: April 6, 2026

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