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major histocompatibility complex, class I-related

Summary

Gene Symbol

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

25119

PubChem

25119

Alliance of Genome Resources

RGD:1593291

Annotation

Keyword

Cell membrane
Disulfide bond
Endoplasmic reticulum
Endosome
Glycoprotein
Golgi apparatus
Immunoglobulin domain
Innate immunity
MHC I
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
O19477	MHC class I-related gene protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
antigen processing and presentation of peptide antigen via MHC class I	IEA
positive regulation of T cell mediated cytotoxicity directed against tumor cell target	ISO
positive regulation of T cell mediated cytotoxicity directed against tumor cell target	IEA
immune response	IBA
antigen processing and presentation of exogenous antigen	ISO

GO Hierarchy

biological process

immune system process [inference]

immune response

innate immune response

antigen processing and presentation [inference]

antigen processing and presentation of exogenous antigen

antigen processing and presentation of peptide antigen [inference]

antigen processing and presentation of peptide antigen via MHC class I

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

T cell differentiation in thymus

T cell activation [inference]

T cell differentiation [inference]

T cell differentiation in thymus

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

T cell differentiation in thymus

T cell activation [inference]

T cell differentiation [inference]

T cell differentiation in thymus

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

T cell differentiation in thymus

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

T cell differentiation in thymus

T cell activation [inference]

T cell differentiation [inference]

T cell differentiation in thymus

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

T cell differentiation in thymus

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to other organism [inference]

defense response to bacterium [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to bacterium [inference]

innate immune response

immune response

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to other organism [inference]

defense response to bacterium [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to other organism [inference]

defense response to bacterium [inference]

innate immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of immune effector process [inference]

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of leukocyte mediated immunity [inference]

regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity directed against tumor cell target [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of leukocyte mediated immunity [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of lymphocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated immunity [inference]

regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity directed against tumor cell target [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity directed against tumor cell target [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of immune response [inference]

regulation of adaptive immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of T cell mediated immunity [inference]

regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity directed against tumor cell target [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity directed against tumor cell target [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of immune response to tumor cell [inference]

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity directed against tumor cell target [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of cellular process [inference]

positive regulation of cell killing [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of response to tumor cell [inference]

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of response to tumor cell [inference]

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of response to tumor cell [inference]

positive regulation of response to tumor cell [inference]

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of immune response to tumor cell [inference]

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity directed against tumor cell target [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of response to tumor cell [inference]

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of immune response [inference]

regulation of adaptive immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of T cell mediated immunity [inference]

regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity directed against tumor cell target [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity directed against tumor cell target [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of immune response to tumor cell [inference]

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity directed against tumor cell target [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of cellular process [inference]

regulation of cell killing [inference]

regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity directed against tumor cell target [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of cell killing [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of cellular process [inference]

positive regulation of cell killing [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

Displaying entries **6 - 10** of 12 in total

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GO Term	Evidence Code	PMID
plasma membrane	ISO
external side of plasma membrane	IBA
early endosome membrane	ISO
early endosome membrane	IEA
late endosome membrane	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

MHC protein complex [inference]

MHC class I protein complex

cellular anatomical entity [inference]

extracellular space

membrane [inference]

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

endosome membrane [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

side of membrane [inference]

external side of plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
beta-2-microglobulin binding	ISO
beta-2-microglobulin binding	IEA
T cell receptor binding	ISO
T cell receptor binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

T cell receptor binding

beta-2-microglobulin binding

protein-containing complex binding [inference]

T cell receptor binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

class i histocompatibility

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
immune response

Displaying **all 4** entries
InterPro
Immunoglobulin C1-set
MHC class I-like antigen recognition-like superfamily
MHC class I-like antigen recognition-like
MHC classes I/II-like antigen recognition protein

Ortholog

Displaying entries **41 - 50** of 71 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Bos taurus	506206		BOVIN08732
Macaca mulatta	718365		MACMU23667
Monodelphis domestica	100023175		MONDO15995
Equus caballus	100054060		HORSE34868
Pongo abelii	100172054		PONAB17413
Callithrix jacchus	100398548		CALJA16702
Danio rerio	100507436	ZFIN:ZDB-GENE-140820-7
Sus scrofa	100511275		PIGXX36651
Cavia porcellus	100713400		CAVPO07029
Sarcophilus harrisii	100917175		SARHA10067

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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External Links

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OrthoDB (Group)

International Collaboration

Acknowledgements