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MIRAGE

alpha-L-fucosidase 2

Summary

Gene Symbol

FUCA2

Aliases

MGC1314
a-L-fucosidase 2
dJ20N2.5
plasma fucosidase
α-L-fucosidase 2

Organism

Homo sapiens (human)

External Links

NCBI Gene

2519

HGNC

4008

KEGG Gene ID

hsa:2519

PubChem

2519

Alliance of Genome Resources

HGNC:4008

JoGo

FUCA2

TogoVar

FUCA2

Annotation

Keyword

Alternative splicing
Glycoprotein
Glycosidase
Phosphoprotein
Proteomics identification
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9BTY2	Alpha-L-fucoside fucohydrolase 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

1

2

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GO Term	Evidence Code	PMID
carbohydrate metabolic process	IEA
fucose metabolic process	IDA
fucose metabolic process	IBA
fucose metabolic process	IEA
response to bacterium	IMP

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

carbohydrate derivative catabolic process [inference]

glycosyl compound catabolic process [inference]

glycoside catabolic process

primary metabolic process [inference]

carbohydrate metabolic process

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fucose metabolic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fucose metabolic process

carbohydrate derivative metabolic process [inference]

glycoside metabolic process [inference]

glycoside catabolic process

carbohydrate derivative catabolic process [inference]

glycosyl compound catabolic process [inference]

glycoside catabolic process

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium

response to stimulus [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

biological regulation [inference]

regulation of biological process [inference]

regulation of biological process involved in symbiotic interaction [inference]

modulation by symbiont of entry into host [inference]

regulation of entry of bacterium into host cell

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular region	IDA
extracellular region	IEA
obsolete extracellular space
lysosome	IBA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

azurophil granule lumen

intracellular organelle lumen [inference]

vacuolar lumen [inference]

azurophil granule lumen

endoplasmic reticulum lumen

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

azurophil granule lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 4** entries
GO Term	Evidence Code	PMID
alpha-L-fucosidase activity	IDA
alpha-L-fucosidase activity	IBA
alpha-L-fucosidase activity	IEA
protein binding	IPI

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds [inference]

fucosidase activity [inference]

alpha-L-fucosidase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

alpha L fucosidase

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
K: Transcription
M: Cell wall/membrane/envelope biogenesis

Displaying **all 5** entries
Gene Ontology
alpha-L-fucosidase activity
fucose metabolic process
fucosidase activity
hydrolase activity, acting on glycosyl bonds
hydrolase activity

Displaying **all 5** entries
InterPro
Alpha-L-fucosidase, C-terminal
Alpha-L-fucosidase, metazoa-type
Glycoside hydrolase superfamily
Glycoside hydrolase, family 29
Glycosyl hydrolase, all-beta

KEGG BRITE Database

Orthology

K01206

Name

alpha-L-fucosidase [EC:3.2.1.51]

References

Rhea

H₂O + an α-L-fucoside

L-fucose + an alcohol

Enzyme

3.2.1.51

PMID

Ortholog

Displaying **all 4** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	66848	MGI:1914098
Rattus norvegicus	292485	RGD:1303053
Caenorhabditis elegans	189173	WB:WBGene00012225
Drosophila melanogaster	3772574	FB:FBgn0285958

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026