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ATP binding cassette subfamily C member 2

Summary

Gene Symbol

Abcc2

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

25303

PubChem

25303

Alliance of Genome Resources

RGD:2366

Annotation

Keyword

3D-structure
ATP-binding
Cell membrane
Glycoprotein
Lipid transport
Phosphoprotein
Reference proteome
Repeat
Translocase
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q63120	Canalicular multidrug resistance protein Canalicular multispecific organic anion transporter 1 Multidrug resistance-associated protein 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 71 in total

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GO Term	Evidence Code	PMID
glutathione metabolic process	ISO
xenobiotic transmembrane transport	ISO
xenobiotic transmembrane transport	IMP
lipid transport	IEA
response to oxidative stress	IEP

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

phosphatidylinositol 3-kinase/protein kinase B signal transduction

metabolic process [inference]

modified amino acid metabolic process [inference]

glutathione metabolic process

sulfur compound metabolic process [inference]

glutathione metabolic process

penicillin metabolic process [inference]

benzylpenicillin metabolic process

xenobiotic metabolic process [inference]

xenobiotic catabolic process

catabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

heme catabolic process

xenobiotic catabolic process

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

antibiotic metabolic process

secondary metabolic process [inference]

penicillin metabolic process [inference]

benzylpenicillin metabolic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

porphyrin-containing compound catabolic process [inference]

heme catabolic process

heme metabolic process [inference]

heme catabolic process

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

heme catabolic process

pigment metabolic process

heme metabolic process [inference]

heme catabolic process

pigment catabolic process [inference]

heme catabolic process

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mRNA metabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mRNA metabolic process

lipid metabolic process [inference]

steroid metabolic process [inference]

bile acid metabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

bile acid metabolic process

penicillin metabolic process [inference]

benzylpenicillin metabolic process

lactam metabolic process [inference]

penicillin metabolic process [inference]

benzylpenicillin metabolic process

cellular developmental process [inference]

cell differentiation [inference]

cardiocyte differentiation [inference]

cardiac muscle cell differentiation

muscle cell differentiation [inference]

striated muscle cell differentiation [inference]

cardiac muscle cell differentiation

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

cellular response to lipid [inference]

cellular response to lipopolysaccharide

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

cellular response to xenobiotic stimulus

cellular response to oxygen-containing compound [inference]

cellular response to lipopolysaccharide

cellular response to ketone [inference]

cellular response to dexamethasone stimulus

cellular response to biotic stimulus [inference]

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

transmembrane transport

xenobiotic transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

mercury ion transport

xenobiotic export from cell

xenobiotic detoxification by transmembrane export across the plasma membrane

export across plasma membrane [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

export from cell [inference]

xenobiotic export from cell

xenobiotic detoxification by transmembrane export across the plasma membrane

export across plasma membrane [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

reproductive process [inference]

multi-organism reproductive process [inference]

female pregnancy

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

vascular transport [inference]

transport across blood-brain barrier [inference]

xenobiotic transport across blood-brain barrier

multi-multicellular organism process [inference]

female pregnancy

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

epithelium development [inference]

renal tubule development [inference]

nephron tubule development [inference]

proximal tubule development

kidney epithelium development [inference]

nephron epithelium development [inference]

nephron tubule development [inference]

proximal tubule development

tube development [inference]

renal tubule development [inference]

nephron tubule development [inference]

proximal tubule development

animal organ development [inference]

heart development

cellular developmental process [inference]

cell differentiation [inference]

cardiocyte differentiation [inference]

cardiac muscle cell differentiation

muscle cell differentiation [inference]

striated muscle cell differentiation [inference]

cardiac muscle cell differentiation

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic anion homeostasis [inference]

intracellular chloride ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic anion homeostasis [inference]

intracellular chloride ion homeostasis

monoatomic anion homeostasis [inference]

intracellular monoatomic anion homeostasis [inference]

intracellular chloride ion homeostasis

chloride ion homeostasis [inference]

intracellular chloride ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic anion homeostasis [inference]

intracellular chloride ion homeostasis

inorganic ion homeostasis [inference]

chloride ion homeostasis [inference]

intracellular chloride ion homeostasis

response to stimulus [inference]

response to stress [inference]

response to oxidative stress

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

cellular response to lipopolysaccharide

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

cellular response to lipopolysaccharide

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

cellular response to biotic stimulus [inference]

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

response to endogenous stimulus [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

response to peptide hormone [inference]

response to estrogen

response to steroid hormone

response to corticosteroid [inference]

response to glucocorticoid [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

response to dexamethasone [inference]

cellular response to dexamethasone stimulus

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

cellular response to endogenous stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

response to chemical [inference]

response to xenobiotic stimulus

cellular response to xenobiotic stimulus

response to toxic substance

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

response to peptide hormone [inference]

response to estrogen

response to steroid hormone

response to corticosteroid [inference]

response to glucocorticoid [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

response to dexamethasone [inference]

cellular response to dexamethasone stimulus

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

response to metal ion [inference]

response to mercury ion

response to lipid [inference]

response to estradiol

response to lipopolysaccharide

cellular response to lipopolysaccharide

response to steroid hormone

response to corticosteroid [inference]

response to glucocorticoid [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

response to dexamethasone [inference]

cellular response to dexamethasone stimulus

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

cellular response to lipid [inference]

cellular response to lipopolysaccharide

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

response to arsenic-containing substance

cellular response to chemical stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

cellular response to lipid [inference]

cellular response to lipopolysaccharide

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

cellular response to xenobiotic stimulus

cellular response to oxygen-containing compound [inference]

cellular response to lipopolysaccharide

cellular response to ketone [inference]

cellular response to dexamethasone stimulus

response to peptide

response to cytokine [inference]

response to tumor necrosis factor [inference]

cellular response to tumor necrosis factor

response to interleukin-1 [inference]

cellular response to interleukin-1

response to interleukin-6 [inference]

cellular response to interleukin-6

cellular response to cytokine stimulus [inference]

response to nitrogen compound [inference]

response to peptide hormone [inference]

response to oxygen-containing compound [inference]

response to estradiol

response to lipopolysaccharide

cellular response to lipopolysaccharide

response to peptide hormone [inference]

response to ketone [inference]

response to dexamethasone [inference]

cellular response to dexamethasone stimulus

cellular response to ketone [inference]

cellular response to dexamethasone stimulus

response to wortmannin

cellular response to oxygen-containing compound [inference]

cellular response to lipopolysaccharide

cellular response to ketone [inference]

cellular response to dexamethasone stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

cellular response to lipid [inference]

cellular response to lipopolysaccharide

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus [inference]

cellular response to dexamethasone stimulus

cellular response to xenobiotic stimulus

cellular response to oxygen-containing compound [inference]

cellular response to lipopolysaccharide

cellular response to ketone [inference]

cellular response to dexamethasone stimulus

cellular response to biotic stimulus [inference]

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport

transition metal ion transport [inference]

mercury ion transport

monoatomic cation transmembrane transport [inference]

mercury ion transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

mercury ion transport

lipid transport

bile acid and bile salt transport

canalicular bile acid transport

fatty acid transport [inference]

prostaglandin transport

hormone transport [inference]

thyroid hormone transport

vascular transport [inference]

transport across blood-brain barrier [inference]

xenobiotic transport across blood-brain barrier

organic anion transport

glutathione transport

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

bilirubin transport

monocarboxylic acid transport

bile acid and bile salt transport

canalicular bile acid transport

fatty acid transport [inference]

prostaglandin transport

icosanoid transport [inference]

peptide transport [inference]

oligopeptide transport [inference]

tripeptide transport [inference]

glutathione transport

organic acid transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

bilirubin transport

monocarboxylic acid transport

bile acid and bile salt transport

canalicular bile acid transport

fatty acid transport [inference]

prostaglandin transport

icosanoid transport [inference]

organic hydroxy compound transport [inference]

bile acid and bile salt transport

canalicular bile acid transport

xenobiotic transport

xenobiotic transmembrane transport

xenobiotic export from cell

xenobiotic detoxification by transmembrane export across the plasma membrane

xenobiotic transport across blood-brain barrier

secretion [inference]

canalicular bile acid transport

transmembrane transport

xenobiotic transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

mercury ion transport

xenobiotic export from cell

xenobiotic detoxification by transmembrane export across the plasma membrane

export across plasma membrane [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

transepithelial transport

nitrogen compound transport [inference]

oligopeptide transport [inference]

tripeptide transport [inference]

glutathione transport

bilirubin transport

modified amino acid transport [inference]

glutathione transport

sulfur compound transport [inference]

glutathione transport

export from cell [inference]

xenobiotic export from cell

xenobiotic detoxification by transmembrane export across the plasma membrane

export across plasma membrane [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

carbohydrate derivative transport [inference]

glycoside transport [inference]

glucuronoside transport

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone transport [inference]

thyroid hormone transport

detoxification [inference]

detoxification of inorganic compound [inference]

detoxification of mercury ion

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
plasma membrane	ISO
plasma membrane	IBA
cell surface	ISO
membrane	ISO
membrane	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cell surface

membrane

plasma membrane

plasma membrane region [inference]

apical plasma membrane

cell projection membrane [inference]

brush border membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

intercellular canaliculus

organelle [inference]

membrane-bounded organelle [inference]

vesicle

intracellular canaliculus

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	PMID
protein binding	IPI
ATP binding	IEA
obsolete organic anion transmembrane transporter activity
ABC-type xenobiotic transporter activity	ISO
ABC-type xenobiotic transporter activity	IMP

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity [inference]

transmembrane transporter activity

toxin transmembrane transporter activity

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity

xenobiotic transmembrane transporter activity

ABC-type xenobiotic transporter activity

carboxylic acid transmembrane transporter activity

dicarboxylic acid transmembrane transporter activity [inference]

bilirubin transmembrane transporter activity

sulfur compound transmembrane transporter activity [inference]

ABC-type glutathione S-conjugate transporter activity

binding [inference]

protein binding

protein domain specific binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

multidrug resistance-associated

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ABC-type transporter activity
ATP binding
nucleotide binding

Displaying **all 6** entries
InterPro
AAA+ ATPase domain
ABC transporter type 1, transmembrane domain superfamily
ABC transporter type 1, transmembrane domain
ABC transporter-like, ATP-binding domain
ABC transporter-like, conserved site
P-loop containing nucleoside triphosphate hydrolase

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
apical plasma membrane	PMID:28842383
brush border membrane	PMID:16899240

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:12308	Dubin-Johnson syndrome	Alliance of Genome Resources
DOID:13580	cholestasis	Alliance of Genome Resources
DOID:1826	epilepsy	Alliance of Genome Resources
DOID:2741	bilirubin metabolic disorder	Alliance of Genome Resources
DOID:783	end stage renal disease	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements