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Fas ligand

Summary

Gene Symbol

Faslg

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

25385

KEGG Gene ID

PubChem

25385

Alliance of Genome Resources

RGD:3880

Annotation

Keyword

Apoptosis
Cell membrane
Cytokine
Cytoplasmic vesicle
Disulfide bond
Glycoprotein
Lysosome
Nucleus
Reference proteome
Repressor
Secreted
Signal-anchor
Transcription regulation
Transmembrane helix
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A0U5J7X8	CD95 ligand Fas antigen ligand
P36940	CD95 ligand Fas antigen ligand

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 42 in total

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GO Term	Evidence Code	PMID
immune response	IEA
positive regulation of cell population proliferation	IDA
positive regulation of cell population proliferation	IEA
extrinsic apoptotic signaling pathway via death domain receptors	ISO
extrinsic apoptotic signaling pathway via death domain receptors	IMP

GO Hierarchy

biological process

immune system process [inference]

immune response

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

extrinsic apoptotic signaling pathway

extrinsic apoptotic signaling pathway via death domain receptors

apoptotic signaling pathway

extrinsic apoptotic signaling pathway

extrinsic apoptotic signaling pathway via death domain receptors

necroptotic signaling pathway

cell death [inference]

programmed cell death [inference]

apoptotic process

inflammatory cell apoptotic process

leukocyte apoptotic process [inference]

lymphocyte apoptotic process [inference]

T cell apoptotic process

programmed cell death involved in cell development [inference]

retinal cell programmed cell death

programmed necrotic cell death [inference]

necroptotic process

intercellular transport [inference]

release of sequestered calcium ion into cytosol [inference]

release of sequestered calcium ion into cytosol by endoplasmic reticulum

cellular developmental process [inference]

programmed cell death involved in cell development [inference]

retinal cell programmed cell death

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol [inference]

release of sequestered calcium ion into cytosol by endoplasmic reticulum

cellular component organization or biogenesis [inference]

cellular component organization [inference]

membrane organization [inference]

regulation of membrane lipid distribution [inference]

regulation of phospholipid translocation [inference]

positive regulation of phospholipid translocation [inference]

positive regulation of phosphatidylserine exposure on apoptotic cell surface

regulation of phosphatidylserine exposure on apoptotic cell surface [inference]

positive regulation of phosphatidylserine exposure on apoptotic cell surface

developmental process [inference]

cellular developmental process [inference]

programmed cell death involved in cell development [inference]

retinal cell programmed cell death

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic anion homeostasis [inference]

intracellular chloride ion homeostasis

intracellular monoatomic cation homeostasis [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

endosomal lumen acidification

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic anion homeostasis [inference]

intracellular chloride ion homeostasis

intracellular monoatomic cation homeostasis [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

endosomal lumen acidification

monoatomic cation homeostasis [inference]

regulation of pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

endosomal lumen acidification

intracellular monoatomic cation homeostasis [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

endosomal lumen acidification

monoatomic anion homeostasis [inference]

intracellular monoatomic anion homeostasis [inference]

intracellular chloride ion homeostasis

chloride ion homeostasis [inference]

intracellular chloride ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic anion homeostasis [inference]

intracellular chloride ion homeostasis

intracellular monoatomic cation homeostasis [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

endosomal lumen acidification

inorganic ion homeostasis [inference]

chloride ion homeostasis [inference]

intracellular chloride ion homeostasis

response to stimulus [inference]

immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to endogenous stimulus [inference]

response to growth factor

response to chemical [inference]

response to lipid [inference]

response to lipopolysaccharide

response to peptide [inference]

response to cytokine [inference]

response to type II interferon [inference]

cellular response to type II interferon

cellular response to cytokine stimulus [inference]

cellular response to type II interferon

response to oxygen-containing compound [inference]

response to lipopolysaccharide

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol [inference]

release of sequestered calcium ion into cytosol by endoplasmic reticulum

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol [inference]

release of sequestered calcium ion into cytosol by endoplasmic reticulum

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol [inference]

release of sequestered calcium ion into cytosol by endoplasmic reticulum

intercellular transport [inference]

release of sequestered calcium ion into cytosol [inference]

release of sequestered calcium ion into cytosol by endoplasmic reticulum

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol [inference]

release of sequestered calcium ion into cytosol by endoplasmic reticulum

biological regulation [inference]

regulation of pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

endosomal lumen acidification

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of ERBB signaling pathway [inference]

regulation of epidermal growth factor receptor signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of localization [inference]

regulation of transport [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of phospholipid transport [inference]

positive regulation of phospholipid translocation [inference]

positive regulation of phosphatidylserine exposure on apoptotic cell surface

regulation of phospholipid transport [inference]

regulation of phospholipid translocation [inference]

positive regulation of phospholipid translocation [inference]

positive regulation of phosphatidylserine exposure on apoptotic cell surface

regulation of phosphatidylserine exposure on apoptotic cell surface [inference]

positive regulation of phosphatidylserine exposure on apoptotic cell surface

positive regulation of phospholipid transport [inference]

positive regulation of phospholipid translocation [inference]

positive regulation of phosphatidylserine exposure on apoptotic cell surface

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of phospholipid transport [inference]

positive regulation of phospholipid translocation [inference]

positive regulation of phosphatidylserine exposure on apoptotic cell surface

regulation of lipid localization [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of phospholipid transport [inference]

positive regulation of phospholipid translocation [inference]

positive regulation of phosphatidylserine exposure on apoptotic cell surface

regulation of phospholipid transport [inference]

regulation of phospholipid translocation [inference]

positive regulation of phospholipid translocation [inference]

positive regulation of phosphatidylserine exposure on apoptotic cell surface

regulation of phosphatidylserine exposure on apoptotic cell surface [inference]

positive regulation of phosphatidylserine exposure on apoptotic cell surface

positive regulation of phospholipid transport [inference]

positive regulation of phospholipid translocation [inference]

positive regulation of phosphatidylserine exposure on apoptotic cell surface

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of phospholipid transport [inference]

positive regulation of phospholipid translocation [inference]

positive regulation of phosphatidylserine exposure on apoptotic cell surface

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of cellular component organization [inference]

positive regulation of phospholipid translocation [inference]

positive regulation of phosphatidylserine exposure on apoptotic cell surface

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of phospholipid transport [inference]

positive regulation of phospholipid translocation [inference]

positive regulation of phosphatidylserine exposure on apoptotic cell surface

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of phospholipid transport [inference]

positive regulation of phospholipid translocation [inference]

positive regulation of phosphatidylserine exposure on apoptotic cell surface

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of developmental process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of ERBB signaling pathway [inference]

regulation of epidermal growth factor receptor signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

negative regulation of developmental process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

extrinsic apoptotic signaling pathway

extrinsic apoptotic signaling pathway via death domain receptors

apoptotic signaling pathway

extrinsic apoptotic signaling pathway

extrinsic apoptotic signaling pathway via death domain receptors

necroptotic signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of ERBB signaling pathway [inference]

regulation of epidermal growth factor receptor signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

regulation of RNA metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

regulation of RNA metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of neuron apoptotic process [inference]

positive regulation of neuron apoptotic process

regulation of endothelial cell apoptotic process [inference]

positive regulation of endothelial cell apoptotic process

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of cellular component organization [inference]

positive regulation of phospholipid translocation [inference]

positive regulation of phosphatidylserine exposure on apoptotic cell surface

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

regulation of cellular component organization [inference]

positive regulation of cellular component organization [inference]

positive regulation of phospholipid translocation [inference]

positive regulation of phosphatidylserine exposure on apoptotic cell surface

regulation of phospholipid translocation [inference]

positive regulation of phospholipid translocation [inference]

positive regulation of phosphatidylserine exposure on apoptotic cell surface

regulation of phosphatidylserine exposure on apoptotic cell surface [inference]

positive regulation of phosphatidylserine exposure on apoptotic cell surface

regulation of plasma membrane organization [inference]

regulation of phosphatidylserine exposure on apoptotic cell surface [inference]

positive regulation of phosphatidylserine exposure on apoptotic cell surface

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of biological quality [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

endosomal lumen acidification

regulation of membrane lipid distribution [inference]

regulation of phospholipid translocation [inference]

positive regulation of phospholipid translocation [inference]

positive regulation of phosphatidylserine exposure on apoptotic cell surface

regulation of phosphatidylserine exposure on apoptotic cell surface [inference]

positive regulation of phosphatidylserine exposure on apoptotic cell surface

Displaying entries **11 - 15** of 21 in total

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GO Term	Evidence Code	PMID
plasma membrane	IEA
caveola	IDA
external side of plasma membrane	IEA
cell surface	ISO
cell surface	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

plasma membrane

plasma membrane region [inference]

plasma membrane raft [inference]

caveola

membrane microdomain [inference]

membrane raft [inference]

plasma membrane raft [inference]

caveola

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen

intracellular organelle lumen [inference]

vacuolar lumen [inference]

lysosomal lumen

cytoplasmic vesicle lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

perinuclear region of cytoplasm

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
death receptor binding	IC
death receptor binding	IPI
cytokine activity	ISO
cytokine activity	IBA
cytokine activity	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

cytokine receptor binding [inference]

tumor necrosis factor receptor superfamily binding [inference]

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

cytokine activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

cytokine activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Tumor necrosis factor

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
extrinsic apoptotic signaling pathway via death domain receptors
immune response
positive regulation of canonical NF-kappaB signal transduction
tumor necrosis factor receptor binding

Displaying **all 2** entries
InterPro
Tumour necrosis factor domain
Tumour necrosis factor-like domain superfamily

Alliance of Genome Resources

Expression

Displaying **all 4** entries
Location	References
cytoplasm	PMID:21630211
perinuclear region of cytoplasm	PMID:16563377
plasma membrane	PMID:21630211
caveola	PMID:15541714

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:9744	type 1 diabetes mellitus	Alliance of Genome Resources
DOID:303	substance-related disorder	Alliance of Genome Resources
DOID:0060108	brain glioma	Alliance of Genome Resources

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	14103	MGI:99255
Homo sapiens	356	HGNC:11936

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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OrthoDB (Group)

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Acknowledgements