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brevican

Summary

Gene Symbol

Bcan

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

25393

PubChem

25393

Alliance of Genome Resources

RGD:2194

Annotation

Keyword

Alternative splicing
Direct protein sequencing
Disulfide bond
EGF-like domain
Extracellular matrix
GPI-anchor
Hyaluronic acid
Immunoglobulin domain
Lectin
Phosphoprotein
Proteoglycan
Reference proteome
Repeat
Signal
Sushi

Proteins

Displaying **all 4** entries
UniProt	Protein Name
P55068	Brain-enriched hyaluronan-binding protein
A6J642
A6J643
G3V8G4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
skeletal system development	IBA
positive regulation of neuroblast proliferation
cell adhesion	IEA
cell-matrix adhesion	IDA	11208904
central nervous system development	IBA

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

cell-substrate adhesion [inference]

cell-matrix adhesion

cell growth [inference]

developmental cell growth [inference]

neuron projection extension

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation

neurogenesis [inference]

gliogenesis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell junction organization [inference]

synapse organization [inference]

synapse maturation

developmental process [inference]

developmental maturation [inference]

synapse maturation

anatomical structure development [inference]

hippocampus development

system development [inference]

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation

neurogenesis [inference]

gliogenesis

growth [inference]

cell growth [inference]

developmental cell growth [inference]

neuron projection extension

developmental growth [inference]

developmental cell growth [inference]

neuron projection extension

developmental growth involved in morphogenesis [inference]

neuron projection extension

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of neural precursor cell proliferation [inference]

positive regulation of neuroblast proliferation

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of neural precursor cell proliferation [inference]

positive regulation of neuroblast proliferation

regulation of neural precursor cell proliferation [inference]

regulation of neuroblast proliferation [inference]

positive regulation of neuroblast proliferation

positive regulation of neural precursor cell proliferation [inference]

positive regulation of neuroblast proliferation

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of neural precursor cell proliferation [inference]

positive regulation of neuroblast proliferation

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of biological quality [inference]

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	PMID
extracellular region	IEA
extracellular space	IDA	7592978
extracellular space	IBA
cell surface	IDA	12799382
axon	IDA	17709431

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane region [inference]

synaptic membrane

cell junction [inference]

synapse

external encapsulating structure [inference]

extracellular matrix

collagen-containing extracellular matrix [inference]

perisynaptic extracellular matrix

perineuronal net

node of Ranvier

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

Displaying **all 3** entries
GO Term	Evidence Code	PMID
calcium ion binding	IEA
hyaluronic acid binding	IEA
carbohydrate binding	IEA

GO Hierarchy

molecular function

binding [inference]

carbohydrate binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

hyaluronic acid binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Brevican core protein

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 4** entries
Gene Ontology
central nervous system development
hyaluronic acid binding
positive regulation of neuroblast proliferation
skeletal system development

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InterPro
C-type lectin fold
C-type lectin, conserved site
C-type lectin-like/link domain superfamily
C-type lectin-like
EGF-like domain
Immunoglobulin V-set domain
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold

Alliance of Genome Resources

Expression

Displaying **all 8** entries
Location	References
node of Ranvier	PMID:17709431
dendrite	PMID:7592978
extracellular space	PMID:7592978
axon	PMID:17709431
synaptic membrane	PMID:7592978
axon initial segment	PMID:17709431
cell surface	PMID:12799382
perineuronal net	PMID:16644727

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:3070	high grade glioma	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	12032	Xenbase:XB-GENE-5829331	MOUSE37658
Xenopus tropicalis	25393	Xenbase:XB-GENE-5829331
Homo sapiens	63827	Xenbase:XB-GENE-5829331	HUMAN52791
Bos taurus	281019		BOVIN25725
Danio rerio	334113		DANRE11208
Pan troglodytes	457401		PANTR22596
Canis lupus familiaris	612102		CANLF17389
Macaca mulatta	718545		MACMU23576
Felis catus	727695		FELCA36946
Monodelphis domestica	100023489		MONDO13315