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Repository for lectin-assisted multimodality data

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Guidelines

MIRAGE

collagen type II alpha 1 chain

Summary

Gene Symbol

Col2a1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

25412

KEGG Gene ID

[""]

PubChem

25412

Alliance of Genome Resources

RGD:2375

Annotation

Keyword

Calcium
Collagen
Disulfide bond
Extracellular matrix
Glycoprotein
Hydroxylation
Metal-binding
Proteomics identification
Reference proteome
Repeat
Signal

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A8I6AM44
F1LRM7
P05539	Alpha-1 type II collagen

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 55 in total

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GO Term	Evidence Code	PMID
skeletal system development	ISO
cartilage condensation	ISO
ossification	ISO
tissue homeostasis	ISO
endochondral ossification	ISO

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

extrinsic apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway in absence of ligand

signal transduction in absence of ligand [inference]

extrinsic apoptotic signaling pathway in absence of ligand

apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway in absence of ligand

metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process

primary metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process

cellular developmental process [inference]

cell differentiation [inference]

chondrocyte differentiation

cellular response to stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin E

cellular response to chemical stimulus [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin E

cellular response to hormone stimulus [inference]

cellular response to parathyroid hormone stimulus

cellular response to peptide hormone stimulus

cellular response to insulin-like growth factor stimulus

cellular response to nicotine

cellular response to lipid [inference]

cellular response to retinoic acid

cellular response to nitrogen compound [inference]

cellular response to peptide hormone stimulus

cellular response to insulin-like growth factor stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide hormone stimulus

cellular response to insulin-like growth factor stimulus

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

cell aggregation [inference]

cartilage condensation

multicellular organismal process [inference]

replacement ossification [inference]

endochondral ossification

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of light stimulus [inference]

visual perception

sensory perception of mechanical stimulus [inference]

sensory perception of sound

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

heart morphogenesis

embryonic organ morphogenesis [inference]

embryonic skeletal system morphogenesis [inference]

embryonic skeletal joint morphogenesis

skeletal system morphogenesis

embryonic skeletal system morphogenesis [inference]

embryonic skeletal joint morphogenesis

appendage morphogenesis [inference]

limb morphogenesis

embryonic morphogenesis [inference]

inner ear morphogenesis

embryonic organ morphogenesis [inference]

embryonic skeletal system morphogenesis [inference]

embryonic skeletal joint morphogenesis

anatomical structure formation involved in morphogenesis [inference]

limb bud formation

anatomical structure development [inference]

tissue development [inference]

epithelium development [inference]

otic vesicle development

connective tissue development [inference]

growth plate cartilage development

tube development [inference]

otic vesicle development

animal organ development [inference]

sensory organ development [inference]

otic vesicle development

embryonic organ development [inference]

notochord development

cartilage development

cartilage development involved in endochondral bone morphogenesis

growth plate cartilage development

bone development

system development [inference]

inner ear development

otic vesicle development

roof of mouth development

head development [inference]

anterior head development

cellular developmental process [inference]

cell differentiation [inference]

chondrocyte differentiation

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis

response to stimulus [inference]

response to external stimulus [inference]

response to mechanical stimulus

cellular response to mechanical stimulus

cellular response to external stimulus [inference]

cellular response to mechanical stimulus

response to abiotic stimulus [inference]

response to radiation [inference]

response to ionizing radiation [inference]

response to X-ray

response to mechanical stimulus

cellular response to mechanical stimulus

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

response to endogenous stimulus [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to parathyroid hormone stimulus

cellular response to peptide hormone stimulus

cellular response to insulin-like growth factor stimulus

response to peptide hormone [inference]

cellular response to peptide hormone stimulus

cellular response to insulin-like growth factor stimulus

response to parathyroid hormone [inference]

cellular response to parathyroid hormone stimulus

response to growth factor [inference]

cellular response to growth factor stimulus [inference]

cellular response to BMP stimulus

response to BMP [inference]

cellular response to BMP stimulus

response to fibroblast growth factor

cellular response to endogenous stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to parathyroid hormone stimulus

cellular response to peptide hormone stimulus

cellular response to insulin-like growth factor stimulus

cellular response to growth factor stimulus [inference]

cellular response to BMP stimulus

response to nutrient levels [inference]

response to nutrient [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin E

response to vitamin [inference]

response to vitamin E [inference]

cellular response to vitamin E

cellular response to vitamin [inference]

cellular response to vitamin E

cellular response to nutrient levels [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin E

response to chemical [inference]

response to nutrient [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin E

response to vitamin [inference]

response to vitamin E [inference]

cellular response to vitamin E

cellular response to vitamin [inference]

cellular response to vitamin E

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to parathyroid hormone stimulus

cellular response to peptide hormone stimulus

cellular response to insulin-like growth factor stimulus

response to peptide hormone [inference]

cellular response to peptide hormone stimulus

cellular response to insulin-like growth factor stimulus

response to parathyroid hormone [inference]

cellular response to parathyroid hormone stimulus

response to lipid [inference]

response to retinoic acid [inference]

cellular response to retinoic acid

cellular response to lipid [inference]

cellular response to retinoic acid

response to nicotine [inference]

cellular response to nicotine

cellular response to chemical stimulus [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin E

cellular response to hormone stimulus [inference]

cellular response to parathyroid hormone stimulus

cellular response to peptide hormone stimulus

cellular response to insulin-like growth factor stimulus

cellular response to nicotine

cellular response to lipid [inference]

cellular response to retinoic acid

cellular response to nitrogen compound [inference]

cellular response to peptide hormone stimulus

cellular response to insulin-like growth factor stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide hormone stimulus

cellular response to insulin-like growth factor stimulus

response to peptide [inference]

response to cytokine [inference]

response to tumor necrosis factor [inference]

cellular response to tumor necrosis factor

cellular response to cytokine stimulus [inference]

cellular response to tumor necrosis factor

response to nitrogen compound [inference]

response to peptide hormone [inference]

cellular response to peptide hormone stimulus

cellular response to insulin-like growth factor stimulus

cellular response to nitrogen compound [inference]

cellular response to peptide hormone stimulus

cellular response to insulin-like growth factor stimulus

response to oxygen-containing compound [inference]

response to retinoic acid [inference]

cellular response to retinoic acid

response to vitamin E [inference]

cellular response to vitamin E

response to peptide hormone [inference]

cellular response to peptide hormone stimulus

cellular response to insulin-like growth factor stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide hormone stimulus

cellular response to insulin-like growth factor stimulus

cellular response to stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin E

cellular response to chemical stimulus [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin E

cellular response to hormone stimulus [inference]

cellular response to parathyroid hormone stimulus

cellular response to peptide hormone stimulus

cellular response to insulin-like growth factor stimulus

cellular response to nicotine

cellular response to lipid [inference]

cellular response to retinoic acid

cellular response to nitrogen compound [inference]

cellular response to peptide hormone stimulus

cellular response to insulin-like growth factor stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide hormone stimulus

cellular response to insulin-like growth factor stimulus

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of signal transduction in absence of ligand [inference]

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

regulation of extrinsic apoptotic signaling pathway in absence of ligand [inference]

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of signal transduction in absence of ligand [inference]

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of signal transduction in absence of ligand [inference]

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of signal transduction in absence of ligand [inference]

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of signal transduction in absence of ligand [inference]

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of signal transduction in absence of ligand [inference]

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

regulation of extrinsic apoptotic signaling pathway in absence of ligand [inference]

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of signal transduction in absence of ligand [inference]

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

extrinsic apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway in absence of ligand

signal transduction in absence of ligand [inference]

extrinsic apoptotic signaling pathway in absence of ligand

apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway in absence of ligand

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of signal transduction in absence of ligand [inference]

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

regulation of extrinsic apoptotic signaling pathway in absence of ligand [inference]

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of signal transduction in absence of ligand [inference]

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

regulation of extrinsic apoptotic signaling pathway in absence of ligand [inference]

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of signal transduction in absence of ligand [inference]

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
extracellular region	ISO
collagen trimer	ISO
collagen type II trimer	ISO
collagen type II trimer	IBA
collagen type II trimer	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

collagen trimer

fibrillar collagen trimer [inference]

extracellular protein-containing complex [inference]

fibrillar collagen trimer [inference]

cellular anatomical structure [inference]

external encapsulating structure [inference]

extracellular matrix

basement membrane

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
extracellular matrix structural constituent	ISO
extracellular matrix structural constituent	IEA
extracellular matrix structural constituent conferring tensile strength	IBA
MHC class II protein binding	ISO
MHC class II protein binding	IEA

GO Hierarchy

molecular function

structural molecule activity [inference]

extracellular matrix structural constituent

extracellular matrix structural constituent conferring tensile strength

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

MHC protein binding [inference]

MHC class II protein binding

growth factor binding [inference]

platelet-derived growth factor binding

identical protein binding

protein homodimerization activity

proteoglycan binding

protein dimerization activity [inference]

protein homodimerization activity

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

carbohydrate derivative binding [inference]

proteoglycan binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

collagen

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
extracellular matrix structural constituent conferring tensile strength
extracellular matrix structural constituent

Displaying **all 2** entries
InterPro
Collagen triple helix repeat
Fibrillar collagen, C-terminal

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
collagen-containing extracellular matrix	PMID:7649371

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:1459	hypothyroidism	Alliance of Genome Resources
DOID:8398	osteoarthritis	Alliance of Genome Resources
DOID:90	degenerative disc disease	Alliance of Genome Resources

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Last updated: April 6, 2026