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microtubule-associated protein 2

Summary

Gene Symbol

Map2

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

25595

PubChem

25595

Alliance of Genome Resources

RGD:3044

Annotation

Keyword

Alternative splicing
Calmodulin-binding
Cell projection
Cytoskeleton
Microtubule
Phosphoprotein
Reference proteome
Repeat

Proteins

Displaying **all 8** entries
UniProt	Protein Name
A6KFC4
Q78DZ1
F1MAQ5
A6KFC7
Q64715
A0A9K3Y814
F1LNK0
P15146

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 15** of 24 in total

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GO Term	Evidence Code	PMID
negative regulation of axon extension	IMP	28426968
negative regulation of microtubule polymerization	IMP	28426968
neuron projection development	ISO
neuron projection development	IBA
response to estradiol	IEP	21683086

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization

microtubule bundle formation

establishment or maintenance of cell polarity [inference]

establishment of cell polarity

cellular developmental process [inference]

cell development [inference]

neuron development [inference]

central nervous system neuron development

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization

microtubule bundle formation

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development

dendrite development

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

anatomical structure development [inference]

dendrite development

cell development [inference]

neuron development [inference]

central nervous system neuron development

cellular developmental process [inference]

cell development [inference]

neuron development [inference]

central nervous system neuron development

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to progesterone

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to progesterone

response to organic cyclic compound [inference]

response to estradiol

response to steroid hormone [inference]

response to progesterone

response to lipid [inference]

response to estradiol

response to steroid hormone [inference]

response to progesterone

response to ketone [inference]

response to progesterone

response to oxygen-containing compound [inference]

response to estradiol

response to ketone [inference]

response to progesterone

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of vesicle transport along microtubule [inference]

positive regulation of cytoplasmic transport [inference]

positive regulation of dense core granule transport [inference]

positive regulation of anterograde dense core granule transport

regulation of organelle transport along microtubule

regulation of vesicle transport along microtubule [inference]

positive regulation of vesicle transport along microtubule [inference]

regulation of anterograde dense core granule transport [inference]

positive regulation of anterograde dense core granule transport

regulation of anterograde synaptic vesicle transport [inference]

positive regulation of anterograde synaptic vesicle transport

regulation of cytoplasmic transport [inference]

positive regulation of cytoplasmic transport [inference]

positive regulation of dense core granule transport [inference]

positive regulation of anterograde dense core granule transport

regulation of dense core granule transport [inference]

regulation of anterograde dense core granule transport [inference]

positive regulation of anterograde dense core granule transport

positive regulation of dense core granule transport [inference]

positive regulation of anterograde dense core granule transport

positive regulation of transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of vesicle transport along microtubule [inference]

positive regulation of cytoplasmic transport [inference]

positive regulation of dense core granule transport [inference]

positive regulation of anterograde dense core granule transport

positive regulation of synaptic vesicle transport [inference]

positive regulation of anterograde synaptic vesicle transport

regulation of synaptic vesicle transport [inference]

positive regulation of synaptic vesicle transport [inference]

positive regulation of anterograde synaptic vesicle transport

regulation of anterograde synaptic vesicle transport [inference]

positive regulation of anterograde synaptic vesicle transport

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of vesicle transport along microtubule [inference]

positive regulation of cytoplasmic transport [inference]

positive regulation of dense core granule transport [inference]

positive regulation of anterograde dense core granule transport

regulation of organelle transport along microtubule

regulation of vesicle transport along microtubule [inference]

positive regulation of vesicle transport along microtubule [inference]

regulation of anterograde dense core granule transport [inference]

positive regulation of anterograde dense core granule transport

regulation of anterograde synaptic vesicle transport [inference]

positive regulation of anterograde synaptic vesicle transport

regulation of cytoplasmic transport [inference]

positive regulation of cytoplasmic transport [inference]

positive regulation of dense core granule transport [inference]

positive regulation of anterograde dense core granule transport

regulation of dense core granule transport [inference]

regulation of anterograde dense core granule transport [inference]

positive regulation of anterograde dense core granule transport

positive regulation of dense core granule transport [inference]

positive regulation of anterograde dense core granule transport

regulation of protein localization

regulation of growth [inference]

regulation of cell growth [inference]

negative regulation of cell growth [inference]

negative regulation of axon extension

regulation of extent of cell growth [inference]

regulation of axon extension [inference]

negative regulation of axon extension

negative regulation of growth [inference]

negative regulation of cell growth [inference]

negative regulation of axon extension

negative regulation of developmental growth [inference]

negative regulation of axon extension

regulation of developmental growth [inference]

regulation of axon extension [inference]

negative regulation of axon extension

negative regulation of developmental growth [inference]

negative regulation of axon extension

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of intracellular transport [inference]

positive regulation of vesicle transport along microtubule [inference]

positive regulation of cytoplasmic transport [inference]

positive regulation of dense core granule transport [inference]

positive regulation of anterograde dense core granule transport

positive regulation of synaptic vesicle transport [inference]

positive regulation of anterograde synaptic vesicle transport

positive regulation of transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of vesicle transport along microtubule [inference]

positive regulation of cytoplasmic transport [inference]

positive regulation of dense core granule transport [inference]

positive regulation of anterograde dense core granule transport

positive regulation of synaptic vesicle transport [inference]

positive regulation of anterograde synaptic vesicle transport

negative regulation of biological process [inference]

negative regulation of growth [inference]

negative regulation of cell growth [inference]

negative regulation of axon extension

negative regulation of developmental growth [inference]

negative regulation of axon extension

negative regulation of cellular process [inference]

negative regulation of cell growth [inference]

negative regulation of axon extension

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of microtubule polymerization

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of protein-containing complex disassembly [inference]

negative regulation of protein depolymerization [inference]

negative regulation of microtubule depolymerization

negative regulation of supramolecular fiber organization [inference]

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of developmental growth [inference]

negative regulation of axon extension

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of axonogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

regulation of developmental growth [inference]

regulation of axon extension [inference]

negative regulation of axon extension

negative regulation of developmental growth [inference]

negative regulation of axon extension

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of developmental growth [inference]

negative regulation of axon extension

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

regulation of cellular process [inference]

regulation of microtubule-based process [inference]

regulation of microtubule-based movement [inference]

regulation of organelle transport along microtubule

regulation of vesicle transport along microtubule [inference]

positive regulation of vesicle transport along microtubule [inference]

regulation of anterograde dense core granule transport [inference]

positive regulation of anterograde dense core granule transport

regulation of anterograde synaptic vesicle transport [inference]

positive regulation of anterograde synaptic vesicle transport

regulation of microtubule cytoskeleton organization [inference]

regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

regulation of microtubule polymerization [inference]

negative regulation of microtubule polymerization

regulation of microtubule depolymerization [inference]

negative regulation of microtubule depolymerization

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of microtubule polymerization

regulation of protein polymerization [inference]

regulation of microtubule polymerization [inference]

negative regulation of microtubule polymerization

negative regulation of protein polymerization [inference]

negative regulation of microtubule polymerization

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

positive regulation of cellular process [inference]

positive regulation of intracellular transport [inference]

positive regulation of vesicle transport along microtubule [inference]

positive regulation of cytoplasmic transport [inference]

positive regulation of dense core granule transport [inference]

positive regulation of anterograde dense core granule transport

positive regulation of synaptic vesicle transport [inference]

positive regulation of anterograde synaptic vesicle transport

negative regulation of cellular process [inference]

negative regulation of cell growth [inference]

negative regulation of axon extension

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of microtubule polymerization

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of protein-containing complex disassembly [inference]

negative regulation of protein depolymerization [inference]

negative regulation of microtubule depolymerization

negative regulation of supramolecular fiber organization [inference]

regulation of cellular component organization [inference]

regulation of cell growth [inference]

negative regulation of cell growth [inference]

negative regulation of axon extension

regulation of extent of cell growth [inference]

regulation of axon extension [inference]

negative regulation of axon extension

regulation of cell projection organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

negative regulation of neuron projection development [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

regulation of axonogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

regulation of organelle organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

regulation of cytoskeleton organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

regulation of microtubule cytoskeleton organization [inference]

regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

regulation of microtubule polymerization [inference]

negative regulation of microtubule polymerization

regulation of microtubule depolymerization [inference]

negative regulation of microtubule depolymerization

regulation of protein-containing complex disassembly [inference]

negative regulation of protein-containing complex disassembly [inference]

negative regulation of protein depolymerization [inference]

negative regulation of microtubule depolymerization

regulation of protein depolymerization [inference]

regulation of microtubule depolymerization [inference]

negative regulation of microtubule depolymerization

negative regulation of protein depolymerization [inference]

negative regulation of microtubule depolymerization

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of microtubule polymerization

regulation of protein polymerization [inference]

regulation of microtubule polymerization [inference]

negative regulation of microtubule polymerization

negative regulation of protein polymerization [inference]

negative regulation of microtubule polymerization

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of microtubule polymerization

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of protein-containing complex disassembly [inference]

negative regulation of protein depolymerization [inference]

negative regulation of microtubule depolymerization

negative regulation of supramolecular fiber organization [inference]

regulation of supramolecular fiber organization [inference]

regulation of microtubule polymerization [inference]

negative regulation of microtubule polymerization

regulation of microtubule depolymerization [inference]

negative regulation of microtubule depolymerization

negative regulation of supramolecular fiber organization [inference]

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of vesicle transport along microtubule [inference]

positive regulation of cytoplasmic transport [inference]

positive regulation of dense core granule transport [inference]

positive regulation of anterograde dense core granule transport

regulation of organelle transport along microtubule

regulation of vesicle transport along microtubule [inference]

positive regulation of vesicle transport along microtubule [inference]

regulation of anterograde dense core granule transport [inference]

positive regulation of anterograde dense core granule transport

regulation of anterograde synaptic vesicle transport [inference]

positive regulation of anterograde synaptic vesicle transport

regulation of cytoplasmic transport [inference]

positive regulation of cytoplasmic transport [inference]

positive regulation of dense core granule transport [inference]

positive regulation of anterograde dense core granule transport

regulation of dense core granule transport [inference]

regulation of anterograde dense core granule transport [inference]

positive regulation of anterograde dense core granule transport

positive regulation of dense core granule transport [inference]

positive regulation of anterograde dense core granule transport

regulation of protein localization

regulation of synaptic vesicle transport [inference]

positive regulation of synaptic vesicle transport [inference]

positive regulation of anterograde synaptic vesicle transport

regulation of anterograde synaptic vesicle transport [inference]

positive regulation of anterograde synaptic vesicle transport

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of binding [inference]

negative regulation of protein binding [inference]

negative regulation of microtubule binding

regulation of binding [inference]

regulation of protein binding [inference]

negative regulation of protein binding [inference]

negative regulation of microtubule binding

regulation of microtubule binding [inference]

negative regulation of microtubule binding

negative regulation of binding [inference]

negative regulation of protein binding [inference]

negative regulation of microtubule binding

Displaying entries **11 - 15** of 47 in total

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GO Term	Evidence Code	PMID
cilium	IEA
postsynaptic density	ISO
actin cytoskeleton	IMP	11029056
microtubule cytoskeleton	IMP	11029056
dendrite	ISO

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

cytoplasm

cytoplasmic region [inference]

plasma membrane bounded cell projection cytoplasm [inference]

neuron projection cytoplasm [inference]

dendrite cytoplasm

cytosol

membrane [inference]

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

ruffle membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

site of polarized growth [inference]

growth cone [inference]

dendritic growth cone

leading edge membrane [inference]

ruffle membrane

nuclear periphery

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium

neuron projection

dendrite

dendritic branch

apical dendrite

apical distal dendrite

distal dendrite

apical distal dendrite

proximal dendrite

actin-based cell projection [inference]

filopodium [inference]

dendritic filopodium

organelle [inference]

membrane-bounded organelle [inference]

cilium

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

postsynaptic specialization [inference]

postsynaptic density

dendrite terminus [inference]

dendritic growth cone

cell body

neuronal cell body

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
dystroglycan binding	ISO
dystroglycan binding	IEA
actin binding	IMP	11029056
protein binding	IPI	15623521 21632941 28426968
calmodulin binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

actin binding

tubulin binding [inference]

microtubule binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

protein domain specific binding [inference]

SH2 domain binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

microtubule-associated protein

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
microtubule binding
microtubule cytoskeleton organization
neuron projection development
tubulin binding

Displaying **all 2** entries
InterPro
Microtubule associated protein MAP2/MAP4/Tau
Microtubule associated protein, tubulin-binding repeat

Alliance of Genome Resources

Expression

Displaying **all 4** entries
Location	References
neuronal cell body	PMID:21401443
dendrite	PMID:15623521
protein-containing complex	PMID:15623521
dendritic shaft	PMID:23121659

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:3526	cerebral infarction	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 61 in total

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Species	Gene ID	Orthologous MAtrix
Ictidomys tridecemlineatus	101956247	ICTTR02832
Chinchilla lanigera	102003839	CHILA14639
Myotis lucifugus	102434557	MYOLU00970
Pelodiscus sinensis	102443832	PELSI15249
Chlorocebus sabaeus	103217747	CHLSB01575
Carlito syrichta	103250024	CARSF07585
Ursus maritimus	103659814	URSMA01539
Rhinopithecus roxellana	104655503	RHIRO27863
Pteropus vampyrus	105298390	PTEVA09377
Macaca nemestrina	105481123	MACNE17712

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements