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glutamate decarboxylase 2

Summary

Gene Symbol

GAD2

Aliases

GAD65

Organism

Homo sapiens (human)

External Links

NCBI Gene

2572

HGNC

4093

KEGG Gene ID

["hsa:2572"]

PubChem

2572

Alliance of Genome Resources

HGNC:4093

JoGo

GAD2

TogoVar

GAD2

Annotation

Keyword

3D-structure
Cell membrane
Cell projection
Cytoplasm
Cytoplasmic vesicle
Decarboxylase
Golgi apparatus
Neurotransmitter biosynthesis
Palmitate
Phosphoprotein
Proteomics identification
Pyridoxal phosphate
Reference proteome
Synapse

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q05329	65 kDa glutamic acid decarboxylase Glutamate decarboxylase 65 kDa isoform
Q5VZ30	65 kDa glutamic acid decarboxylase Glutamate decarboxylase 65 kDa isoform

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
GABA shunt	TAS
GABA shunt	IBA
chemical synaptic transmission	TAS
GABA biosynthetic process	IBA
carboxylic acid metabolic process	IEA

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

metabolic process [inference]

biosynthetic process [inference]

amino acid biosynthetic process [inference]

GABA biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

non-proteinogenic amino acid biosynthetic process [inference]

GABA biosynthetic process

primary metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

GABA biosynthetic process

proteinogenic amino acid metabolic process [inference]

GABA shunt

non-proteinogenic amino acid metabolic process [inference]

GABA metabolic process [inference]

GABA biosynthetic process

non-proteinogenic amino acid biosynthetic process [inference]

GABA biosynthetic process

alpha-amino acid metabolic process [inference]

glutamate metabolic process [inference]

GABA shunt

L-amino acid metabolic process [inference]

GABA shunt

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

non-proteinogenic amino acid biosynthetic process [inference]

GABA biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process

monocarboxylic acid metabolic process [inference]

GABA metabolic process [inference]

GABA biosynthetic process

dicarboxylic acid metabolic process [inference]

succinate metabolic process [inference]

GABA shunt

glutamate metabolic process [inference]

GABA shunt

carboxylic acid biosynthetic process [inference]

non-proteinogenic amino acid biosynthetic process [inference]

GABA biosynthetic process

proteinogenic amino acid metabolic process [inference]

GABA shunt

non-proteinogenic amino acid metabolic process [inference]

GABA metabolic process [inference]

GABA biosynthetic process

non-proteinogenic amino acid biosynthetic process [inference]

GABA biosynthetic process

alpha-amino acid metabolic process [inference]

glutamate metabolic process [inference]

GABA shunt

L-amino acid metabolic process [inference]

GABA shunt

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

non-proteinogenic amino acid biosynthetic process [inference]

GABA biosynthetic process

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

Displaying entries **1 - 5** of 10 in total

1

2

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GO Term	Evidence Code	PMID
Golgi membrane	IEA
cytoplasm	IBA
cytoplasm	IEA
cytosol	IEA
plasma membrane	TAS

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

coated vesicle membrane [inference]

clathrin-coated vesicle membrane [inference]

clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane

bounding membrane of organelle [inference]

Golgi membrane

coated vesicle membrane [inference]

clathrin-coated vesicle membrane [inference]

clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic membrane

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

Displaying entries **1 - 5** of 6 in total

1

2

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GO Term	Evidence Code	PMID
glutamate decarboxylase activity	IBA
glutamate decarboxylase activity	IEA
protein binding	IPI
carbon-carbon lyase activity	IEA
carboxy-lyase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

lyase activity [inference]

carbon-carbon lyase activity

carboxy-lyase activity

glutamate decarboxylase activity

binding [inference]

protein binding

small molecule binding [inference]

vitamin binding [inference]

vitamin B6 binding [inference]

pyridoxal phosphate binding

ion binding [inference]

anion binding [inference]

pyridoxal phosphate binding

heterocyclic compound binding [inference]

vitamin B6 binding [inference]

pyridoxal phosphate binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Glutamate decarboxylase

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
J: Translation, ribosomal structure and biogenesis

Displaying **all 5** entries
Gene Ontology
carbon-carbon lyase activity
carboxy-lyase activity
carboxylic acid metabolic process
lyase activity
pyridoxal phosphate binding

Displaying **all 3** entries
InterPro
Pyridoxal phosphate-dependent decarboxylase
Pyridoxal phosphate-dependent transferase, major domain
Pyridoxal phosphate-dependent transferase

KEGG BRITE Database

Orthology

K01580

Name

glutamate decarboxylase [EC:4.1.1.15]

References

Rhea

RHEA:17785

H⁺ + L-glutamate

CO₂ + 4-aminobutanoate

Enzyme

4.1.1.15

PMID

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:0050741	alcohol dependence	Alliance of Genome Resources
DOID:11714	gestational diabetes	Alliance of Genome Resources
DOID:1742	drug psychosis	Alliance of Genome Resources
DOID:5419	schizophrenia	Alliance of Genome Resources
DOID:670	amphetamine abuse	Alliance of Genome Resources
DOID:9744	type 1 diabetes mellitus	Alliance of Genome Resources
DOID:9976	heroin dependence	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

International Collaboration

Acknowledgements