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cyclin G associated kinase

Summary

Gene Symbol

GAK

Organism

Homo sapiens (human)

External Links

NCBI Gene

2580

KEGG Gene ID

[""]

PubChem

2580

Alliance of Genome Resources

HGNC:4113

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Alternative splicing
Cell cycle
Cell junction
Cytoplasm
Cytoplasmic vesicle
Golgi apparatus
Kinase
Methylation
Phosphoprotein
Proteomics identification
Reference proteome
Serine/threonine-protein kinase

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B4DS37
O14976	DnaJ homolog subfamily C member 26

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
protein folding	TAS
receptor-mediated endocytosis	IMP
endoplasmic reticulum organization	ISS
Golgi organization	IMP
negative regulation of neuron projection development	IDA

GO Hierarchy

biological process

cellular process [inference]

protein folding

intercellular transport [inference]

Golgi to vacuole transport [inference]

Golgi to lysosome transport

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

clathrin-dependent endocytosis

Golgi vesicle transport [inference]

post-Golgi vesicle-mediated transport [inference]

Golgi to vacuole transport [inference]

Golgi to lysosome transport

cellular localization [inference]

intracellular transport

vacuolar transport [inference]

Golgi to vacuole transport [inference]

Golgi to lysosome transport

lysosomal transport [inference]

Golgi to lysosome transport

cytosolic transport [inference]

Golgi to lysosome transport

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cellular component disassembly [inference]

protein-containing complex disassembly [inference]

protein depolymerization [inference]

vesicle uncoating [inference]

clathrin coat disassembly

synaptic vesicle uncoating

cellular component assembly [inference]

protein-containing complex assembly [inference]

clathrin coat assembly

protein-containing complex organization [inference]

protein-containing complex disassembly [inference]

protein depolymerization [inference]

vesicle uncoating [inference]

clathrin coat disassembly

synaptic vesicle uncoating

protein-containing complex assembly [inference]

clathrin coat assembly

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein localization to organelle [inference]

protein localization to Golgi apparatus

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

establishment of localization [inference]

transport [inference]

intercellular transport [inference]

Golgi to vacuole transport [inference]

Golgi to lysosome transport

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

clathrin-dependent endocytosis

Golgi vesicle transport [inference]

post-Golgi vesicle-mediated transport [inference]

Golgi to vacuole transport [inference]

Golgi to lysosome transport

intracellular transport

vacuolar transport [inference]

Golgi to vacuole transport [inference]

Golgi to lysosome transport

lysosomal transport [inference]

Golgi to lysosome transport

cytosolic transport [inference]

Golgi to lysosome transport

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis

clathrin-dependent endocytosis

establishment of localization in cell [inference]

intracellular transport

vacuolar transport [inference]

Golgi to vacuole transport [inference]

Golgi to lysosome transport

lysosomal transport [inference]

Golgi to lysosome transport

cytosolic transport [inference]

Golgi to lysosome transport

cellular localization [inference]

intracellular transport

vacuolar transport [inference]

Golgi to vacuole transport [inference]

Golgi to lysosome transport

lysosomal transport [inference]

Golgi to lysosome transport

cytosolic transport [inference]

Golgi to lysosome transport

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

regulation of cellular process [inference]

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

regulation of clathrin coat assembly

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

negative regulation of neuron projection development

regulation of protein-containing complex assembly [inference]

regulation of clathrin coat assembly

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
cytoplasm	IBA
Golgi apparatus	IDA
Golgi apparatus	IEA
cytosol	TAS
focal adhesion	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

organelle [inference]

membrane-bounded organelle [inference]

vesicle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

intracellular membrane-bounded organelle

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
protein kinase activity	IEA
protein serine/threonine kinase activity	IDA
protein serine/threonine kinase activity	IEA
protein binding	IPI
ATP binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity

binding [inference]

protein binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

protein folding chaperone

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

protein kinase

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
AP-2 adaptor complex binding
ATP binding
positive regulation of Notch signaling pathway
regulation of clathrin-dependent endocytosis

Displaying **all 8** entries
InterPro
C2 domain superfamily
Chaperone J-domain superfamily
DnaJ domain
Protein kinase domain
Protein kinase-like domain superfamily
Protein-tyrosine phosphatase-like
Serine/threonine-protein kinase, active site
Tensin phosphatase, C2 domain