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polypeptide N-acetylgalactosaminyltransferase 2

Summary

Gene Symbol

GALNT2

Aliases

GalNAc-T2
polypeptide GalNAc transferase 2

Organism

Homo sapiens (human)

External Links

NCBI Gene

2590

GGDB ID

gg088

HGNC

4124

mRNA

NM_004481

map

1q41-q42

Protein

NP_004472

OMIM

602274

KEGG Gene ID

hsa:2590

PubChem

2590

Alliance of Genome Resources

HGNC:4124

JoGo

GALNT2

TogoVar

GALNT2

Annotation

Keyword

3D-structure
Alternative splicing
Congenital disorder of glycosylation
Direct protein sequencing
Disease variant
Disulfide bond
Glycosyltransferase
Golgi apparatus
Lectin
Manganese
Metal-binding
Phosphoprotein
Proteoglycan
Proteomics identification
Reference proteome
Secreted
Signal
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A1L7NY50	Protein-UDP acetylgalactosaminyltransferase
B7Z6K2	Protein-UDP acetylgalactosaminyltransferase
Q10471	Polypeptide GalNAc transferase 2 Protein-UDP acetylgalactosaminyltransferase 2 UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
positive regulation of immunoglobulin production	IDA
protein O-linked glycosylation	IDA
protein O-linked glycosylation	IBA
protein O-linked glycosylation via N-acetyl-galactosamine	TAS
protein O-linked glycosylation via N-acetyl-galactosamine	IDA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation

protein O-linked glycosylation via N-acetyl-galactosamine

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation

protein O-linked glycosylation via N-acetyl-galactosamine

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation

protein O-linked glycosylation via N-acetyl-galactosamine

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation

protein O-linked glycosylation via N-acetyl-galactosamine

protein maturation

primary metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation

protein O-linked glycosylation via N-acetyl-galactosamine

protein maturation

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation

protein O-linked glycosylation via N-acetyl-galactosamine

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation

protein O-linked glycosylation via N-acetyl-galactosamine

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production

regulation of immune effector process [inference]

positive regulation of immune effector process [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production

regulation of production of molecular mediator of immune response [inference]

regulation of immunoglobulin production [inference]

positive regulation of immunoglobulin production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

regulation of immunoglobulin production [inference]

positive regulation of immunoglobulin production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

regulation of immunoglobulin production [inference]

positive regulation of immunoglobulin production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production

Displaying entries **6 - 10** of 13 in total

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GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	TAS
Golgi apparatus	IDA
Golgi apparatus	IBA
Golgi apparatus	IEA
Golgi stack	IDA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

Golgi stack

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

perinuclear region of cytoplasm

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
polypeptide N-acetylgalactosaminyltransferase activity	TAS
polypeptide N-acetylgalactosaminyltransferase activity	IDA
polypeptide N-acetylgalactosaminyltransferase activity	IBA
polypeptide N-acetylgalactosaminyltransferase activity	IEA
protein binding	IPI

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

acetylgalactosaminyltransferase activity [inference]

polypeptide N-acetylgalactosaminyltransferase activity

hexosyltransferase activity [inference]

acetylgalactosaminyltransferase activity [inference]

polypeptide N-acetylgalactosaminyltransferase activity

catalytic activity, acting on a protein [inference]

polypeptide N-acetylgalactosaminyltransferase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

manganese ion binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000143641

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg088

Gene Symbol

GALNT2

Orthologous Gene

Displaying **all 4** entries
Species	Protein	mRNA
Caenorhabditis elegans	NP_507850	NM_075449
Mus musculus	NP_644678	NM_139272
Drosophila melanogaster	NP_995625	NM_205903
Rattus norvegicus	XP_238057	XM_238057

KEGG BRITE Database

Orthology

K00710

Name

polypeptide N-acetylgalactosaminyltransferase [EC:2.4.1.41]

References

9295285

Rhea

RHEA:23956

UDP-N-acetyl-α-D-galactosamine

H⁺ + UDP

Enzyme

2.4.1.41

PMID

RHEA:52424

UDP-N-acetyl-α-D-galactosamine

H⁺ + UDP

Enzyme

2.4.1.41

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0050571	congenital disorder of glycosylation type II	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 40 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000020	Urinary incontinence
HP:0000248	Brachycephaly
HP:0000252	Microcephaly
HP:0000276	Long face
HP:0000316	Hypertelorism
HP:0000322	Short philtrum
HP:0000348	High forehead
HP:0000358	Posteriorly rotated ears
HP:0000369	Low-set ears

Displaying 1 entry
Disease ID	Disease Name
OMIM:618885	congenital disorder of glycosylation, type iit

PubChem Disease

MedGen Diseases

Congenital disorder of glycosylation, type iit

OMIM Phenotypes

CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIt; CDG2T

KEGG Diseases

Congenital disorders of glycosylation type II

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying **all 8** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	108148	MGI:894694
Rattus norvegicus	292090	RGD:1310692
Caenorhabditis elegans	180302	WB:WBGene00001629
Drosophila melanogaster	33556	FB:FBgn0031530
Danio rerio	570248	ZFIN:ZDB-GENE-041111-110
Xenopus laevis	108716128	Xenbase:XB-GENE-17346352
Xenopus laevis	101027298	Xenbase:XB-GENE-6486521
Xenopus tropicalis	100488284	Xenbase:XB-GENE-980077

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

GlycoGene Database (GGDB)

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements