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2-hydroxyacyl-CoA lyase 1

Summary

Gene Symbol

HACL1

Organism

Homo sapiens (human)

External Links

NCBI Gene

26061

KEGG Gene ID

PubChem

26061

Alliance of Genome Resources

HGNC:17856

Annotation

Keyword

Alternative splicing
Fatty acid metabolism
Lyase
Magnesium
Metal-binding
Peroxisome
Phosphoprotein
Proteomics identification
Reference proteome
Thiamine pyrophosphate

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B4DXR1
Q9UJ83	2-hydroxyphytanoyl-CoA lyase Phytanoyl-CoA 2-hydroxylase 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
fatty acid alpha-oxidation	IDA
fatty acid alpha-oxidation	IBA
fatty acid alpha-oxidation	IEA
protein targeting to peroxisome	IMP
fatty acid metabolic process	IDA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

lipid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid alpha-oxidation

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid alpha-oxidation

primary metabolic process [inference]

lipid metabolic process [inference]

fatty acid metabolic process

long-chain fatty acid metabolic process [inference]

phytanic acid metabolic process

fatty acid catabolic process [inference]

fatty acid alpha-oxidation

fatty acid oxidation [inference]

fatty acid alpha-oxidation

methyl-branched fatty acid metabolic process

phytanic acid metabolic process

lipid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid alpha-oxidation

lipid modification [inference]

lipid oxidation [inference]

fatty acid oxidation [inference]

fatty acid alpha-oxidation

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid alpha-oxidation

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

long-chain fatty acid metabolic process [inference]

phytanic acid metabolic process

fatty acid catabolic process [inference]

fatty acid alpha-oxidation

fatty acid oxidation [inference]

fatty acid alpha-oxidation

methyl-branched fatty acid metabolic process

phytanic acid metabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid alpha-oxidation

carboxylic acid catabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid alpha-oxidation

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid alpha-oxidation

localization [inference]

establishment of localization [inference]

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to peroxisome

establishment of protein localization to organelle [inference]

establishment of protein localization to peroxisome [inference]

protein targeting to peroxisome

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
nucleoplasm
peroxisome	IDA
peroxisome	IBA
peroxisome	IEA
peroxisomal matrix	TAS

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

microbody lumen [inference]

peroxisomal matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

microbody [inference]

peroxisome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

microbody [inference]

peroxisome

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
magnesium ion binding	IDA
magnesium ion binding	IEA
catalytic activity	IEA
protein binding	IPI
ATP binding	IDA

GO Hierarchy

molecular function

catalytic activity

lyase activity

carbon-carbon lyase activity

aldehyde-lyase activity [inference]

2-hydroxyacyl-CoA lyase activity

2-hydroxyphytanoyl-CoA lyase activity

binding [inference]

protein binding

identical protein binding

small molecule binding [inference]

vitamin binding [inference]

thiamine pyrophosphate binding

ion binding [inference]

anion binding [inference]

thiamine pyrophosphate binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

thiamine pyrophosphate binding

metal ion binding [inference]

magnesium ion binding

quaternary ammonium group binding [inference]

thiamine pyrophosphate binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

thiamine pyrophosphate binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

sulfur compound binding [inference]

thiamine pyrophosphate binding

Gene Ontology information from NCBI Gene and UniProt.

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

GlyCosmos Portal v4.5.0

Last updated: April 6, 2026

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