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glucagon receptor

Summary

Gene Symbol

GCGR

Organism

Homo sapiens (human)

External Links

NCBI Gene

2642

PubChem

2642

Alliance of Genome Resources

HGNC:4192

JoGo

GCGR

TogoVar

GCGR

Annotation

Keyword

3D-structure
Cell membrane
Diabetes mellitus
Disease variant
Disulfide bond
G-protein coupled receptor
Glycoprotein
Phosphoprotein
Proteomics identification
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P47871

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
generation of precursor metabolites and energy	TAS
cell surface receptor signaling pathway	IEA
G protein-coupled receptor signaling pathway	IEA
adenylate cyclase-modulating G protein-coupled receptor signaling pathway	TAS
adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IMP

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

metabolic process [inference]

generation of precursor metabolites and energy

cellular response to stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stress [inference]

cellular response to starvation

cellular response to chemical stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

cellular response to nitrogen compound [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

homeostatic process [inference]

chemical homeostasis [inference]

carbohydrate homeostasis [inference]

glucose homeostasis

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to starvation

response to starvation

cellular response to starvation

response to endogenous stimulus [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

response to peptide hormone [inference]

response to glucagon [inference]

cellular response to glucagon stimulus

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

cellular response to endogenous stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

response to nutrient levels [inference]

response to nutrient

cellular response to nutrient levels [inference]

cellular response to starvation

response to starvation

cellular response to starvation

response to chemical [inference]

response to nutrient

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

response to peptide hormone [inference]

response to glucagon [inference]

cellular response to glucagon stimulus

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

cellular response to chemical stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

cellular response to nitrogen compound [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

response to nitrogen compound [inference]

response to peptide hormone [inference]

response to glucagon [inference]

cellular response to glucagon stimulus

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

cellular response to nitrogen compound [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

response to oxygen-containing compound [inference]

response to peptide hormone [inference]

response to glucagon [inference]

cellular response to glucagon stimulus

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

cellular response to stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stress [inference]

cellular response to starvation

cellular response to chemical stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

cellular response to nitrogen compound [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of generation of precursor metabolites and energy [inference]

regulation of glycogen metabolic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of polysaccharide metabolic process [inference]

regulation of glycogen metabolic process

regulation of primary metabolic process [inference]

regulation of carbohydrate metabolic process [inference]

regulation of polysaccharide metabolic process [inference]

regulation of glycogen metabolic process

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of biological quality [inference]

regulation of blood pressure

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
plasma membrane	EXP
plasma membrane	TAS
plasma membrane	IDA
plasma membrane	IMP
plasma membrane	IBA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

plasma membrane

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
transmembrane signaling receptor activity	IEA
G protein-coupled receptor activity	IEA
glucagon receptor activity	TAS
glucagon receptor activity	IDA
glucagon receptor activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

hormone binding [inference]

peptide hormone binding

molecular transducer activity [inference]

signaling receptor activity [inference]

peptide receptor activity [inference]

G protein-coupled peptide receptor activity [inference]

glucagon receptor activity

transmembrane signaling receptor activity

G protein-coupled receptor activity

G protein-coupled peptide receptor activity [inference]

glucagon receptor activity

molecular function regulator activity [inference]

enzyme regulator activity [inference]

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

guanyl-nucleotide exchange factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

vasoactive intestinal polypeptide

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
G protein-coupled peptide receptor activity
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
cell surface receptor signaling pathway
peptide hormone binding

Displaying **all 5** entries
InterPro
GPCR family 2, extracellular hormone receptor domain superfamily
GPCR, family 2, extracellular hormone receptor domain
GPCR, family 2, secretin-like, conserved site
GPCR, family 2, secretin-like
GPCR, family 2-like, 7TM