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torsin family 1, member A

Summary

Gene Symbol

Tor1a

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

266606

KEGG Gene ID

PubChem

266606

Alliance of Genome Resources

RGD:628863

Annotation

Keyword

Cell projection
Cytoplasmic vesicle
Endoplasmic reticulum
Glycoprotein
Hydrolase
Membrane
Nucleus
Reference proteome
Signal
Synapse

Proteins

Displaying 1 entry
UniProt	Protein Name
Q68G38	Dystonia 1 protein Torsin ATPase 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 46 in total

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GO Term	Evidence Code	PMID
protein deneddylation	ISS
protein deneddylation	ISO
protein deneddylation	IEA
protein folding	ISS
protein folding	ISO

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein metabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deneddylation

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deneddylation

primary metabolic process [inference]

protein metabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deneddylation

intermediate filament-based process [inference]

intermediate filament cytoskeleton organization

synaptic vesicle transport

cell motility [inference]

cell migration [inference]

wound healing, spreading of cells

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization

cytoskeleton organization [inference]

intermediate filament cytoskeleton organization

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development

membrane organization [inference]

response to stimulus [inference]

response to stress [inference]

response to oxidative stress

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

response to chemical [inference]

ERAD pathway

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus

establishment of localization [inference]

transport [inference]

synaptic vesicle transport

establishment of localization in cell [inference]

establishment of vesicle localization [inference]

synaptic vesicle transport

establishment of organelle localization [inference]

establishment of vesicle localization [inference]

synaptic vesicle transport

organelle localization [inference]

vesicle localization [inference]

establishment of vesicle localization [inference]

synaptic vesicle transport

synaptic vesicle localization [inference]

synaptic vesicle transport

establishment of organelle localization [inference]

establishment of vesicle localization [inference]

synaptic vesicle transport

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of protein localization [inference]

regulation of protein localization to cell surface

regulation of transport [inference]

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of synaptic vesicle endocytosis

positive regulation of synaptic vesicle recycling [inference]

positive regulation of synaptic vesicle endocytosis

regulation of neurotransmitter transport [inference]

regulation of neurotransmitter uptake [inference]

regulation of dopamine uptake involved in synaptic transmission

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of synaptic vesicle endocytosis

regulation of synaptic vesicle endocytosis [inference]

positive regulation of synaptic vesicle endocytosis

regulation of synaptic vesicle recycling [inference]

regulation of synaptic vesicle endocytosis [inference]

positive regulation of synaptic vesicle endocytosis

positive regulation of synaptic vesicle recycling [inference]

positive regulation of synaptic vesicle endocytosis

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of synaptic vesicle endocytosis

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of synaptic vesicle endocytosis

positive regulation of synaptic vesicle recycling [inference]

positive regulation of synaptic vesicle endocytosis

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of synaptic vesicle endocytosis

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of synaptic vesicle endocytosis

regulation of synaptic vesicle endocytosis [inference]

positive regulation of synaptic vesicle endocytosis

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of synaptic vesicle endocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of synaptic vesicle endocytosis

regulation of synaptic vesicle endocytosis [inference]

positive regulation of synaptic vesicle endocytosis

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GO Term	Evidence Code	PMID
nucleus	ISO
nucleus	IEA
nuclear envelope	ISS
nuclear envelope	ISO
nuclear envelope	IBA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane

organelle inner membrane [inference]

nuclear inner membrane

nuclear membrane

nuclear inner membrane

site of polarized growth [inference]

growth cone

organelle envelope [inference]

nuclear envelope

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

secretory granule

exocytic vesicle [inference]

synaptic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

secretory granule

exocytic vesicle [inference]

synaptic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

secretory granule

exocytic vesicle [inference]

synaptic vesicle

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GO Term	Evidence Code	PMID
protein binding	IPI
ATP binding	IEA
cytoskeletal protein binding	ISO
cytoskeletal protein binding	IEA
ATP hydrolysis activity	ISS

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

binding [inference]

protein binding

cytoskeletal protein binding

kinesin binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

protein folding chaperone [inference]

ATP-dependent protein folding chaperone

ATP-dependent activity [inference]

ATP-dependent protein folding chaperone

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Torsin

Functional Category

J: Translation, ribosomal structure and biogenesis
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
ATP binding

Displaying **all 4** entries
InterPro
ClpA/B family
P-loop containing nucleoside triphosphate hydrolase
Torsin-1A, C-terminal domain
Torsin

Ortholog

Displaying **all 4** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	30931	MGI:1353568
Caenorhabditis elegans	174433	WB:WBGene00003870
Drosophila melanogaster	31399	FB:FBgn0025615
Homo sapiens	1861	HGNC:3098

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements