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latent transforming growth factor beta binding protein 1

Summary

Gene Symbol

Ltbp1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

268977

PubChem

268977

Alliance of Genome Resources

MGI:109151

Annotation

Keyword

Alternative splicing
Disulfide bond
EGF-like domain
Extracellular matrix
Glycoprotein
Growth factor binding
Hydroxylation
Phosphoprotein
Reference proteome
Repeat
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8CG19	Transforming growth factor beta-1-binding protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
ventricular septum development	IMP
transforming growth factor beta receptor signaling pathway	TAS
positive regulation of collagen biosynthetic process	ISO
obsolete sequestering of TGFbeta in extracellular matrix
establishment of protein localization to extracellular region	ISO

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

transforming growth factor beta receptor signaling pathway

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

cytokine production [inference]

transforming growth factor beta production

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

cytokine production [inference]

transforming growth factor beta production

multicellular organismal process [inference]

cytokine production [inference]

transforming growth factor beta production

developmental process [inference]

anatomical structure development [inference]

blood vessel development [inference]

artery development [inference]

aorta development

coronary vasculature development

cardiac septum development [inference]

ventricular septum development

localization [inference]

establishment of localization [inference]

establishment of protein localization [inference]

establishment of protein localization to extracellular region

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of collagen biosynthetic process

positive regulation of collagen metabolic process [inference]

positive regulation of collagen biosynthetic process

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

transforming growth factor beta receptor signaling pathway

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of collagen biosynthetic process

regulation of collagen biosynthetic process [inference]

positive regulation of collagen biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of collagen biosynthetic process

positive regulation of collagen metabolic process [inference]

positive regulation of collagen biosynthetic process

regulation of collagen metabolic process [inference]

positive regulation of collagen metabolic process [inference]

positive regulation of collagen biosynthetic process

regulation of collagen biosynthetic process [inference]

positive regulation of collagen biosynthetic process

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of collagen biosynthetic process

positive regulation of collagen metabolic process [inference]

positive regulation of collagen biosynthetic process

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
microfibril	ISO
microfibril	IDA
microfibril	IEA
extracellular region	ISS
extracellular region	ISO

GO Hierarchy

cellular component

protein-containing complex

large latent transforming growth factor-beta complex

extracellular protein-containing complex [inference]

transforming growth factor beta complex

cellular anatomical structure [inference]

extracellular region

external encapsulating structure [inference]

extracellular matrix

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

cell body [inference]

neuronal cell body

perinuclear region of cytoplasm

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
extracellular matrix structural constituent	RCA
calcium ion binding	IEA
transforming growth factor beta binding	ISO
transforming growth factor beta binding	IEA
microfibril binding	ISO

GO Hierarchy

molecular function

structural molecule activity [inference]

extracellular matrix structural constituent

binding [inference]

protein binding [inference]

growth factor binding [inference]

transforming growth factor beta binding

cytokine binding [inference]

transforming growth factor beta binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

extracellular matrix binding [inference]

microfibril binding

molecular adaptor activity

molecular function regulator activity [inference]

molecular function inhibitor activity [inference]

receptor ligand inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

latent-transforming growth factor beta-binding

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
calcium ion binding

Displaying **all 8** entries
InterPro
EGF-like calcium-binding domain
EGF-like calcium-binding, conserved site
EGF-like domain
EGF-type aspartate/asparagine hydroxylation site
Growth factor receptor cysteine-rich domain superfamily
NOTCH1 EGF-like calcium-binding domain
TB domain
TGF-beta binding (TB) domain superfamily