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glycerol kinase

Summary

Gene Symbol

Aliases

Organism

Homo sapiens (human)

External Links

NCBI Gene

2710

HGNC

4289

KEGG Gene ID

hsa:2710

PubChem

2710

Alliance of Genome Resources

HGNC:4289

JoGo

TogoVar

Annotation

Keyword

ATP-binding
Alternative splicing
Cytoplasm
Disease variant
Glycerol metabolism
Kinase
Metal-binding
Mitochondrion outer membrane
Nucleus
Proteomics identification
Reference proteome
Transmembrane helix
Zinc

Proteins

Displaying **all 3** entries
UniProt	Protein Name
B4DH54
A0A8I5KXY7
P32189	ATP:glycerol 3-phosphotransferase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
carbohydrate metabolic process	IEA
glycerol metabolic process	IMP
glycerol metabolic process	IBA
glycerol-3-phosphate metabolic process	IEA
triglyceride metabolic process	IMP

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

alditol phosphate metabolic process [inference]

glycerol-3-phosphate metabolic process

glycerol-3-phosphate biosynthetic process

organophosphate metabolic process [inference]

alditol phosphate metabolic process [inference]

glycerol-3-phosphate metabolic process

glycerol-3-phosphate biosynthetic process

organophosphate biosynthetic process [inference]

glycerol-3-phosphate biosynthetic process

catabolic process [inference]

carbohydrate catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

small molecule catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

biosynthetic process [inference]

lipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

organophosphate biosynthetic process [inference]

glycerol-3-phosphate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycerol-3-phosphate biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process

glycerol metabolic process

glycerol catabolic process

carbohydrate catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

triglyceride biosynthetic process

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

lipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

triglyceride biosynthetic process

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

glycerol metabolic process

glycerol catabolic process

polyol catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

small molecule catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

carbohydrate derivative metabolic process [inference]

alditol phosphate metabolic process [inference]

glycerol-3-phosphate metabolic process

glycerol-3-phosphate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycerol-3-phosphate biosynthetic process

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
nucleus	EXP
nucleus	IDA
nucleus	IEA
mitochondrion	IDA
mitochondrion	IBA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytosol

membrane [inference]

outer membrane [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle membrane [inference]

mitochondrial membrane [inference]

mitochondrial outer membrane

bounding membrane of organelle [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
glycerol kinase activity	EXP
glycerol kinase activity	NAS
glycerol kinase activity	TAS
glycerol kinase activity	IDA
glycerol kinase activity	IMP

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity

glycerol kinase activity

phosphotransferase activity, alcohol group as acceptor

glycerol kinase activity

binding [inference]

protein binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

glycerol kinase

Functional Category

C: Energy production and conversion
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying entries **1 - 10** of 12 in total

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Gene Ontology
ATP binding
glycerol catabolic process
glycerol kinase activity
glycerol metabolic process
glycerol-3-phosphate biosynthetic process
glycerol-3-phosphate metabolic process
kinase activity
nucleotide binding
phosphorylation
phosphotransferase activity, alcohol group as acceptor

Displaying **all 6** entries
InterPro
ATPase, nucleotide binding domain
Carbohydrate kinase FGGY, C-terminal
Carbohydrate kinase FGGY, N-terminal
Carbohydrate kinase, FGGY, conserved site
Carbohydrate kinase, FGGY
Glycerol kinase

Human Protein Atlas

ENSG00000198814

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K00864

Name

glycerol kinase [EC:2.7.1.30]

References

14756771

Rhea

RHEA:21644

glycerol + ATP

H⁺ + ADP + sn-glycerol 3-phosphate

Enzyme

2.7.1.30

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060363	glycerol kinase deficiency	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 35 in total

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HPO ID	HPO Term
HP:0000028	Cryptorchidism
HP:0000316	Hypertelorism
HP:0000369	Low-set ears
HP:0000486	Strabismus
HP:0000846	Adrenal insufficiency
HP:0000939	Osteoporosis
HP:0001249	Intellectual disability
HP:0001250	Seizure
HP:0001254	Lethargy
HP:0001259	Coma

Displaying 1 entry
Disease ID	Disease Name
OMIM:307030	inborn glycerol kinase deficiency

PubChem Disease

MedGen Diseases

Inborn glycerol kinase deficiency

OMIM Phenotypes

GLYCEROL KINASE DEFICIENCY; GKD

KEGG Diseases

Glycerol kinase deficiency

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001251
Gene Name: glycerol kinase

Ortholog

Displaying **all 4** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	14933	MGI:106594
Rattus norvegicus	79223	RGD:70893
Caenorhabditis elegans	173747	WB:WBGene00020007
Saccharomyces cerevisiae S288C	856353	SGD:S000001024

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements