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GLI family zinc finger 2
Summary
- Gene Symbol
-
- GLI2
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- Acetylation
- Activator
- Alternative splicing
- Cilium
- Cytoplasm
- DNA-binding
- Developmental protein
- Disease variant
- Holoprosencephaly
- Isopeptide bond
- Nucleus
- Phosphoprotein
- Proteomics identification
- Reference proteome
- Repeat
- Repressor
- Transcription regulation
- Ubl conjugation
- Zinc-finger
- Proteins
| UniProt | Protein Name |
|---|---|
| Q59FV5 |
|
| P10070 |
|
| A0A7I2PJA1 |
|
| Q1PSW9 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| negative regulation of transcription by RNA polymerase II | ||
| negative regulation of transcription by RNA polymerase II | ||
| skeletal system development | ||
| osteoblast differentiation | ||
| kidney development |
GO Hierarchy
biological process
cellular process [inference]
developmental process [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
regulation of cell activation [inference]
regulation of multicellular organismal process [inference]
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | ||
| DNA-binding transcription factor activity, RNA polymerase II-specific | ||
| DNA-binding transcription factor activity | ||
| protein binding | ||
| zinc ion binding |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- zinc finger protein
- Functional Category
-
- G: Carbohydrate transport and metabolism
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| metal ion binding |
| smoothened signaling pathway |
| InterPro |
|---|
| C2H2-type zinc-finger protein GLI-like |
| Zinc finger C2H2 superfamily |
| Zinc finger C2H2-type |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0080016 | spina bifida | |
| DOID:0080328 | Culler-Jones syndrome | |
| DOID:0110873 | holoprosencephaly 9 |
