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Guidelines

MIRAGE

dopamine beta-hydroxylase

Summary

Gene Symbol

DBH

Organism

Bos taurus (domestic cattle)

External Links

NCBI Gene: 280758
KEGG Gene ID: [""]
PubChem: 280758

Annotation

Keyword

Catecholamine biosynthesis
Copper
Cytoplasmic vesicle
Direct protein sequencing
Disulfide bond
Glycoprotein
Metal-binding
Monooxygenase
Reference proteome
Signal-anchor
Transmembrane helix
Vitamin C

Proteins

Displaying 1 entry
UniProt	Protein Name
P15101	Dopamine beta-monooxygenase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 26 in total

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GO Term	Evidence Code	PMID
blood vessel remodeling
response to amphetamine
leukocyte mediated immunity
octopamine biosynthetic process	IEA
memory

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

leukocyte mediated immunity

leukocyte migration

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

amine catabolic process [inference]

biogenic amine catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

biosynthetic process [inference]

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

octopamine biosynthetic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

octopamine biosynthetic process

phenol-containing compound biosynthetic process [inference]

octopamine biosynthetic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

amine metabolic process [inference]

biogenic amine metabolic process [inference]

catecholamine metabolic process [inference]

norepinephrine metabolic process [inference]

norepinephrine biosynthetic process

dopamine metabolic process [inference]

dopamine catabolic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

catecholamine catabolic process [inference]

dopamine catabolic process

biogenic amine biosynthetic process [inference]

octopamine biosynthetic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

octopamine biosynthetic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

amine catabolic process [inference]

biogenic amine catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

phenol-containing compound metabolic process [inference]

catechol-containing compound metabolic process [inference]

catecholamine metabolic process [inference]

norepinephrine metabolic process [inference]

norepinephrine biosynthetic process

dopamine metabolic process [inference]

dopamine catabolic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

catecholamine catabolic process [inference]

dopamine catabolic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

catechol-containing compound catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

phenol-containing compound biosynthetic process [inference]

octopamine biosynthetic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

octopamine metabolic process [inference]

octopamine biosynthetic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

alcohol biosynthetic process [inference]

octopamine biosynthetic process

octopamine metabolic process [inference]

octopamine biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

octopamine biosynthetic process

cell motility [inference]

cell migration [inference]

leukocyte migration

reproductive process [inference]

multicellular organismal reproductive process [inference]

reproductive behavior [inference]

parental behavior [inference]

maternal behavior

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction [inference]

positive regulation of vasoconstriction

vasoconstriction

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

visual learning

memory

behavior [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

visual learning

memory

locomotory behavior

visual behavior [inference]

visual learning

reproductive behavior [inference]

parental behavior [inference]

maternal behavior

adult behavior [inference]

behavioral response to ethanol

multicellular organismal response to stress [inference]

tissue remodeling [inference]

blood vessel remodeling

multicellular organismal-level homeostasis [inference]

temperature homeostasis [inference]

homoiothermy

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

temperature homeostasis [inference]

homoiothermy

chemical homeostasis [inference]

carbohydrate homeostasis [inference]

glucose homeostasis

response to stimulus [inference]

response to stress [inference]

multicellular organismal response to stress [inference]

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

visual behavior [inference]

visual learning

response to chemical [inference]

response to nitrogen compound [inference]

response to amine [inference]

response to amphetamine

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of apoptotic signaling pathway [inference]

regulation of extrinsic apoptotic signaling pathway

positive regulation of biological process [inference]

positive regulation of multicellular organismal process [inference]

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of apoptotic signaling pathway [inference]

regulation of extrinsic apoptotic signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of apoptotic signaling pathway [inference]

regulation of extrinsic apoptotic signaling pathway

regulation of cell population proliferation [inference]

regulation of smooth muscle cell proliferation [inference]

regulation of vascular associated smooth muscle cell proliferation

regulation of epithelial cell proliferation [inference]

regulation of endothelial cell proliferation [inference]

regulation of vascular endothelial cell proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

regulation of apoptotic signaling pathway [inference]

regulation of extrinsic apoptotic signaling pathway

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of vasoconstriction [inference]

positive regulation of vasoconstriction

positive regulation of multicellular organismal process [inference]

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction [inference]

positive regulation of vasoconstriction

vasoconstriction

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
obsolete extracellular space
endoplasmic reticulum
transport vesicle membrane	IEA
secretory granule membrane	IBA
secretory granule membrane	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane

secretory granule membrane

chromaffin granule membrane

bounding membrane of organelle [inference]

transport vesicle membrane

secretory granule membrane

chromaffin granule membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen

chromaffin granule lumen

intracellular organelle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen

chromaffin granule lumen

centriolar satellite

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
dopamine beta-monooxygenase activity	EXP
dopamine beta-monooxygenase activity	IDA
dopamine beta-monooxygenase activity	IBA
dopamine beta-monooxygenase activity	IEA
copper ion binding	IDA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen [inference]

dopamine beta-monooxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen [inference]

dopamine beta-monooxygenase activity

binding [inference]

carbohydrate binding [inference]

monosaccharide binding [inference]

L-ascorbic acid binding

small molecule binding [inference]

vitamin binding [inference]

L-ascorbic acid binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

copper ion binding

organic acid binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

monosaccharide binding [inference]

L-ascorbic acid binding

heterocyclic compound binding [inference]

L-ascorbic acid binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

DBH-like monooxygenase protein 1-like protein

Functional Category

C: Energy production and conversion
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 9** entries
Gene Ontology
catalytic activity
copper ion binding
dopamine beta-monooxygenase activity
dopamine catabolic process
metal ion binding
monooxygenase activity
norepinephrine biosynthetic process
octopamine biosynthetic process
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen

Displaying **all 10** entries
InterPro
Copper type II ascorbate-dependent monooxygenase, C-terminal
Copper type II, ascorbate-dependent monooxygenase, N-terminal domain superfamily
Copper type II, ascorbate-dependent monooxygenase, N-terminal
Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-1 conserved site
Copper type II, ascorbate-dependent monooxygenase-like, C-terminal
Copper-dependent monooxygenases, DOMON domain
DOMON domain
Dopamine beta-hydroxylase-like
PHM/PNGase F domain superfamily
Tyramine beta-hydroxylase/Dopamine beta-hydroxylase

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026