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glycine receptor alpha 1

Summary

Gene Symbol

GLRA1

Organism

Bos taurus (domestic cattle)

External Links

NCBI Gene

281783

KEGG Gene ID

PubChem

281783

Annotation

Keyword

Alternative splicing
Cell membrane
Cell projection
Chloride channel
Disulfide bond
Glycoprotein
Ligand-gated ion channel
Metal-binding
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Transmembrane helix
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
P57695	Glycine receptor 48 kDa subunit Glycine receptor strychnine-binding subunit

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 37 in total

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GO Term	Evidence Code	PMID
startle response	ISS
regulation of respiratory gaseous exchange by nervous system process
monoatomic ion transport	ISS
ion transport	ISS
monoatomic ion transport	IEA

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, glycinergic

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

neuropeptide signaling pathway

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to acid chemical [inference]

cellular response to amino acid stimulus

cellular response to metal ion [inference]

cellular response to zinc ion

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to ethanol

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

reproductive process [inference]

acrosome reaction

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction

nervous system process

regulation of respiratory gaseous exchange by nervous system process

sensory perception [inference]

sensory perception of light stimulus [inference]

visual perception

neuromuscular process [inference]

behavior [inference]

locomotory behavior [inference]

adult locomotory behavior [inference]

adult walking behavior

walking behavior [inference]

adult walking behavior

adult behavior [inference]

adult locomotory behavior [inference]

adult walking behavior

response to stimulus [inference]

response to external stimulus [inference]

startle response

reflex [inference]

righting reflex

response to chemical [inference]

response to acid chemical [inference]

response to amino acid

cellular response to amino acid stimulus

cellular response to acid chemical [inference]

cellular response to amino acid stimulus

response to metal ion [inference]

response to zinc ion [inference]

cellular response to zinc ion

cellular response to metal ion [inference]

cellular response to zinc ion

cellular response to chemical stimulus [inference]

cellular response to acid chemical [inference]

cellular response to amino acid stimulus

cellular response to metal ion [inference]

cellular response to zinc ion

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to ethanol

response to oxygen-containing compound [inference]

response to alcohol

response to ethanol [inference]

cellular response to ethanol

cellular response to alcohol [inference]

cellular response to ethanol

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to ethanol

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to acid chemical [inference]

cellular response to amino acid stimulus

cellular response to metal ion [inference]

cellular response to zinc ion

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to ethanol

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport

monoatomic anion transport [inference]

chloride transport

chloride transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic anion transport [inference]

chloride transport

chloride transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, glycinergic

positive regulation of biological process [inference]

positive regulation of reproductive process [inference]

positive regulation of acrosome reaction

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of transmission of nerve impulse

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system process [inference]

negative regulation of transmission of nerve impulse

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

neuropeptide signaling pathway

regulation of cell communication [inference]

negative regulation of cell communication [inference]

negative regulation of transmission of nerve impulse

regulation of transmission of nerve impulse [inference]

negative regulation of transmission of nerve impulse

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of transmission of nerve impulse

regulation of multicellular organismal process [inference]

regulation of respiratory gaseous exchange [inference]

regulation of respiratory system process [inference]

regulation of respiratory gaseous exchange by nervous system process

regulation of system process [inference]

regulation of nervous system process [inference]

negative regulation of nervous system process [inference]

negative regulation of transmission of nerve impulse

regulation of transmission of nerve impulse [inference]

negative regulation of transmission of nerve impulse

regulation of respiratory system process [inference]

regulation of respiratory gaseous exchange by nervous system process

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system process [inference]

negative regulation of transmission of nerve impulse

regulation of reproductive process [inference]

regulation of acrosome reaction [inference]

positive regulation of acrosome reaction

positive regulation of reproductive process [inference]

positive regulation of acrosome reaction

regulation of biological quality [inference]

regulation of membrane potential

action potential [inference]

neuronal action potential

regulation of postsynaptic membrane potential [inference]

inhibitory postsynaptic potential

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	PMID
plasma membrane	ISS
plasma membrane	EXP
plasma membrane	IBA
plasma membrane	IEA
external side of plasma membrane	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

chloride channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

chloride channel complex

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic membrane

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

dendrite

perikaryon

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

cell body [inference]

neuronal cell body

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
transmembrane signaling receptor activity	IEA
excitatory extracellular ligand-gated monoatomic ion channel activity	IBA
zinc ion binding	ISS
zinc ion binding	IEA
glycine binding	ISS

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity [inference]

extracellularly glycine-gated chloride channel activity

ligand-gated monoatomic anion channel activity [inference]

extracellularly glycine-gated chloride channel activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

excitatory extracellular ligand-gated monoatomic ion channel activity

extracellularly glycine-gated ion channel activity [inference]

extracellularly glycine-gated chloride channel activity

inhibitory extracellular ligand-gated monoatomic ion channel activity [inference]

extracellularly glycine-gated chloride channel activity

transmitter-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

ligand-gated monoatomic anion channel activity [inference]

extracellularly glycine-gated chloride channel activity

ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

monoatomic anion transmembrane transporter activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity [inference]

extracellularly glycine-gated chloride channel activity

ligand-gated monoatomic anion channel activity [inference]

extracellularly glycine-gated chloride channel activity

chloride transmembrane transporter activity [inference]

chloride channel activity [inference]

extracellularly glycine-gated chloride channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity [inference]

extracellularly glycine-gated chloride channel activity

ligand-gated monoatomic anion channel activity [inference]

extracellularly glycine-gated chloride channel activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

excitatory extracellular ligand-gated monoatomic ion channel activity

extracellularly glycine-gated ion channel activity [inference]

extracellularly glycine-gated chloride channel activity

inhibitory extracellular ligand-gated monoatomic ion channel activity [inference]

extracellularly glycine-gated chloride channel activity

transmitter-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

ligand-gated monoatomic anion channel activity [inference]

extracellularly glycine-gated chloride channel activity

ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

excitatory extracellular ligand-gated monoatomic ion channel activity

extracellularly glycine-gated ion channel activity [inference]

extracellularly glycine-gated chloride channel activity

inhibitory extracellular ligand-gated monoatomic ion channel activity [inference]

extracellularly glycine-gated chloride channel activity

transmitter-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

ligand-gated monoatomic anion channel activity [inference]

extracellularly glycine-gated chloride channel activity

ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

binding [inference]

amino acid binding [inference]

glycine binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

glycine binding

alkanesulfonate binding [inference]

taurine binding

cation binding [inference]

glycine binding

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

organic acid binding [inference]

carboxylic acid binding [inference]

glycine binding

alkanesulfonate binding [inference]

taurine binding

sulfur compound binding [inference]

alkanesulfonate binding [inference]

taurine binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity

neurotransmitter receptor activity [inference]

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

gamma-aminobutyric acid receptor

Functional Category

E: Amino acid transport and metabolism
T: Signal transduction mechanisms
X: Mobilome: prophages, transposons

Displaying **all 7** entries
Gene Ontology
chloride channel activity
chloride transmembrane transport
excitatory extracellular ligand-gated monoatomic ion channel activity
extracellular ligand-gated monoatomic ion channel activity
monoatomic ion channel activity
monoatomic ion transport
transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

Displaying **all 8** entries
InterPro
Gamma-aminobutyric acid A receptor/Glycine receptor alpha
Neuronal acetylcholine receptor
Neurotransmitter-gated ion-channel ligand-binding domain superfamily
Neurotransmitter-gated ion-channel ligand-binding domain
Neurotransmitter-gated ion-channel transmembrane domain superfamily
Neurotransmitter-gated ion-channel transmembrane domain
Neurotransmitter-gated ion-channel, conserved site
Neurotransmitter-gated ion-channel

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements