GlyCosmos Portal

Submissions

glutamate ionotropic receptor AMPA type subunit 4

Summary

Gene Symbol

GRIA4

Organism

Homo sapiens (human)

External Links

NCBI Gene

2893

KEGG Gene ID

PubChem

2893

Alliance of Genome Resources

HGNC:4574

Annotation

Keyword

Alternative splicing
Cell membrane
Cell projection
Disease variant
Disulfide bond
Glycoprotein
Intellectual disability
Ligand-gated ion channel
Palmitate
Phosphoprotein
Postsynaptic cell membrane
Proteomics identification
Receptor
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 5** entries
UniProt	Protein Name
A0A8D9PH77
A0A994J6J2
G3V164
Q1WWK6
P48058	AMPA-selective glutamate receptor 4 GluR-D Glutamate receptor ionotropic, AMPA 4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

1

2

3

Next ›

Last »
GO Term	Evidence Code	PMID
monoatomic ion transport	IEA
ion transport	IEA
glutamate receptor signaling pathway	TAS
monoatomic ion transmembrane transport	IEA
ion transmembrane transport	IEA

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, glutamatergic

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway

ionotropic glutamate receptor signaling pathway

ligand-gated ion channel signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

transmembrane transport [inference]

monoatomic ion transmembrane transport

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport

monoatomic ion transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, glutamatergic

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of muscle cell apoptotic process [inference]

negative regulation of smooth muscle cell apoptotic process

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway

ionotropic glutamate receptor signaling pathway

ligand-gated ion channel signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

regulation of muscle cell apoptotic process [inference]

negative regulation of muscle cell apoptotic process [inference]

negative regulation of smooth muscle cell apoptotic process

regulation of smooth muscle cell apoptotic process [inference]

negative regulation of smooth muscle cell apoptotic process

negative regulation of apoptotic process [inference]

negative regulation of muscle cell apoptotic process [inference]

negative regulation of smooth muscle cell apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of muscle cell apoptotic process [inference]

negative regulation of smooth muscle cell apoptotic process

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of muscle cell apoptotic process [inference]

negative regulation of smooth muscle cell apoptotic process

regulation of biological quality [inference]

regulation of membrane potential [inference]

Displaying entries **6 - 10** of 17 in total

« First

‹ Prev

1

2

3

4

Next ›

Last »
GO Term	Evidence Code	PMID
dendrite	ISS
dendrite	IEA
endocytic vesicle membrane	TAS
endocytic vesicle membrane	IEA
AMPA glutamate receptor complex	ISS

GO Hierarchy

cellular component

protein-containing complex [inference]

signaling receptor complex [inference]

plasma membrane signaling receptor complex [inference]

neurotransmitter receptor complex [inference]

ionotropic glutamate receptor complex [inference]

AMPA glutamate receptor complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

neurotransmitter receptor complex [inference]

ionotropic glutamate receptor complex [inference]

AMPA glutamate receptor complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

ionotropic glutamate receptor complex [inference]

AMPA glutamate receptor complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

ionotropic glutamate receptor complex [inference]

AMPA glutamate receptor complex

cellular anatomical structure [inference]

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endocytic vesicle membrane

bounding membrane of organelle [inference]

endocytic vesicle membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic membrane

postsynaptic specialization membrane [inference]

postsynaptic density membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

neuron spine [inference]

dendritic spine

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle

extracellular membrane-bounded organelle [inference]

extracellular vesicle

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle

cell body [inference]

neuronal cell body

postsynapse [inference]

dendritic spine

Displaying entries **1 - 5** of 14 in total

1

2

3

Next ›

Last »
GO Term	Evidence Code	PMID
amyloid-beta binding	NAS
glutamate-gated receptor activity	ISS
glutamate-gated receptor activity	IEA
AMPA glutamate receptor activity	IDA
AMPA glutamate receptor activity	IBA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity

ligand-gated monoatomic ion channel activity

extracellular ligand-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity

AMPA glutamate receptor activity

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

amino acid transmembrane transporter activity [inference]

glutamate-gated receptor activity

AMPA glutamate receptor activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity

ligand-gated monoatomic ion channel activity

extracellular ligand-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity

AMPA glutamate receptor activity

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity

extracellular ligand-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity

AMPA glutamate receptor activity

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity

AMPA glutamate receptor activity

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

carboxylic acid transmembrane transporter activity [inference]

glutamate-gated receptor activity

AMPA glutamate receptor activity

binding [inference]

protein binding

peptide binding [inference]

amyloid-beta binding

molecular transducer activity [inference]

signaling receptor activity

transmembrane signaling receptor activity [inference]

glutamate receptor activity [inference]

glutamate-gated receptor activity

AMPA glutamate receptor activity

neurotransmitter receptor activity [inference]

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity

AMPA glutamate receptor activity

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

GLUTAMATE RECEPTOR

Functional Category

E: Amino acid transport and metabolism
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
ligand-gated monoatomic ion channel activity
modulation of chemical synaptic transmission
monoatomic ion channel activity
monoatomic ion transport
synaptic transmission, glutamatergic
transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

Displaying **all 6** entries
InterPro
Ionotropic glutamate receptor, C-terminal
Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
Ionotropic glutamate receptor, metazoa
Ionotropic glutamate receptor
Periplasmic binding protein-like I
Receptor, ligand binding region

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:5419	schizophrenia	Alliance of Genome Resources

Ortholog

Displaying **all 5** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	14802	MGI:95811
Rattus norvegicus	29629	RGD:61863
Caenorhabditis elegans	176204	WB:WBGene00001612
Caenorhabditis elegans	175999	WB:WBGene00001613
Drosophila melanogaster	38742	FB:FBgn0004619