GlyCosmos Portal

Annotation

Keyword

3D-structure
Acetylation
Cytoplasm
Direct protein sequencing
Disease variant
Hydrolase
Intellectual disability
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
mRNA splicing

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A384MTI8
Q96C86	DCS-1 Decapping scavenger enzyme Hint-related 7meGMP-directed hydrolase Histidine triad nucleotide-binding protein 5 Histidine triad protein member 5 Scavenger mRNA-decapping enzyme DcpS

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	TAS
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IEA
deadenylation-dependent decapping of nuclear-transcribed mRNA	IBA
deadenylation-dependent decapping of nuclear-transcribed mRNA	IEA
mRNA processing

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

mRNA metabolic process [inference]

mRNA processing

mRNA splicing, via spliceosome [inference]

mRNA cis splicing, via spliceosome

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

mRNA methylguanosine-cap decapping

deadenylation-dependent decapping of nuclear-transcribed mRNA

RNA decapping [inference]

mRNA methylguanosine-cap decapping

deadenylation-dependent decapping of nuclear-transcribed mRNA

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

mRNA metabolic process [inference]

mRNA processing

mRNA splicing, via spliceosome [inference]

mRNA cis splicing, via spliceosome

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

mRNA methylguanosine-cap decapping

deadenylation-dependent decapping of nuclear-transcribed mRNA

RNA decapping [inference]

mRNA methylguanosine-cap decapping

deadenylation-dependent decapping of nuclear-transcribed mRNA

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA splicing, via spliceosome [inference]

mRNA cis splicing, via spliceosome

RNA splicing

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome [inference]

mRNA cis splicing, via spliceosome

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of macromolecule metabolic process [inference]

positive regulation of RNA metabolic process [inference]

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA metabolic process [inference]

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of RNA stability [inference]

regulation of mRNA stability [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of mRNA catabolic process [inference]

regulation of mRNA stability [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of macromolecule metabolic process [inference]

positive regulation of RNA metabolic process [inference]

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA metabolic process [inference]

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of RNA stability [inference]

regulation of mRNA stability [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of mRNA catabolic process [inference]

regulation of mRNA stability [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of RNA stability [inference]

regulation of mRNA stability [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of mRNA catabolic process [inference]

regulation of mRNA stability [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of macromolecule metabolic process [inference]

positive regulation of RNA metabolic process [inference]

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA metabolic process [inference]

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of RNA metabolic process [inference]

regulation of RNA stability [inference]

regulation of mRNA stability [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of RNA metabolic process [inference]

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA metabolic process [inference]

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of mRNA metabolic process [inference]

regulation of mRNA catabolic process [inference]

regulation of mRNA stability [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA metabolic process [inference]

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA stability [inference]

regulation of mRNA stability [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of RNA metabolic process [inference]

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA metabolic process [inference]

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of mRNA metabolic process [inference]

regulation of mRNA catabolic process [inference]

regulation of mRNA stability [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA metabolic process [inference]

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of macromolecule metabolic process [inference]

positive regulation of RNA metabolic process [inference]

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA metabolic process [inference]

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of biological quality [inference]

regulation of RNA stability [inference]

regulation of mRNA stability [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
P-body	IBA
nucleus	IDA
nucleus	IBA
nucleus	IEA
nucleoplasm	IDA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

membraneless organelle [inference]

intracellular membraneless organelle [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

P-body

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular membraneless organelle [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

P-body

perinuclear region of cytoplasm

supramolecular complex [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

P-body

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
RNA 7-methylguanosine cap binding	IDA
RNA 7-methylguanosine cap binding	IBA
RNA 7-methylguanosine cap binding	IEA
RNA exonuclease activity	TAS
protein binding	IPI

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity

hydrolase activity, acting on ester bonds [inference]

exonuclease activity [inference]

RNA exonuclease activity

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity

catalytic activity, acting on a nucleic acid [inference]

nuclease activity [inference]

exonuclease activity [inference]

RNA exonuclease activity

RNA nuclease activity [inference]

RNA exonuclease activity

catalytic activity, acting on RNA [inference]

RNA nuclease activity [inference]

RNA exonuclease activity

binding [inference]

nucleic acid binding [inference]

RNA binding [inference]

RNA cap binding [inference]

RNA 7-methylguanosine cap binding

protein binding

identical protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

E3 ubiquitin-protein ligase E3D

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
RNA 7-methylguanosine cap binding
deadenylation-dependent decapping of nuclear-transcribed mRNA
hydrolase activity

Displaying **all 2** entries
InterPro
HIT-like superfamily
Scavenger mRNA decapping enzyme DcpS/DCS2

Human Protein Atlas

ENSG00000110063

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Rhea

RHEA:65384

H₂O

H⁺ + (N²,N²,N⁷)-trimethyl-GMP

Enzyme

3.6.1.59

PMID

15383679

RHEA:65388

H₂O

H⁺ + N⁷-methyl-GMP

Enzyme

3.6.1.59

PMID

Disease

The Human Phenotype Ontology

Displaying entries **1 - 10** of 22 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000160	Narrow mouth
HP:0000219	Thin upper lip vermilion
HP:0000252	Microcephaly
HP:0000369	Low-set ears
HP:0000490	Deeply set eye
HP:0000750	Delayed speech and language development
HP:0001010	Hypopigmentation of the skin
HP:0001156	Brachydactyly
HP:0001250	Seizure