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MIRAGE

drosha ribonuclease III

Summary

Gene Symbol

DROSHA

Organism

Homo sapiens (human)

External Links

NCBI Gene

29102

KEGG Gene ID

PubChem

29102

Alliance of Genome Resources

HGNC:17904

Annotation

Keyword

3D-structure
Alternative splicing
Cytoplasm
Endonuclease
Magnesium
Manganese
Metal-binding
Nucleus
Phosphoprotein
Proteomics identification
RNA-binding
RNA-mediated gene silencing
Reference proteome
Repeat
Ribosome biogenesis

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9NRR4	Protein Drosha Ribonuclease III p241

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
rRNA processing	IEA
RNA processing	IEA
miRNA metabolic process
positive regulation of gene expression	IEA
primary miRNA processing	IDA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

miRNA metabolic process

rRNA metabolic process [inference]

rRNA processing

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

miRNA metabolic process

rRNA metabolic process [inference]

rRNA processing

rRNA processing

regulatory ncRNA processing [inference]

miRNA processing

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to bacterium [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of leukocyte activation [inference]

regulation of lymphocyte activation [inference]

regulation of lymphocyte differentiation [inference]

regulation of T cell differentiation [inference]

regulation of regulatory T cell differentiation

regulation of T cell activation [inference]

regulation of T cell differentiation [inference]

regulation of regulatory T cell differentiation

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

regulation of lymphocyte differentiation [inference]

regulation of T cell differentiation [inference]

regulation of regulatory T cell differentiation

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

regulation of inflammatory response

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of inflammatory response

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of cell development [inference]

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

regulation of lymphocyte differentiation [inference]

regulation of T cell differentiation [inference]

regulation of regulatory T cell differentiation

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

regulation of lymphocyte differentiation [inference]

regulation of T cell differentiation [inference]

regulation of regulatory T cell differentiation

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of RNA metabolic process [inference]

regulation of miRNA metabolic process

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of miRNA metabolic process

regulation of cell differentiation [inference]

regulation of cell development [inference]

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

regulation of lymphocyte differentiation [inference]

regulation of T cell differentiation [inference]

regulation of regulatory T cell differentiation

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

regulation of lymphocyte activation [inference]

regulation of lymphocyte differentiation [inference]

regulation of T cell differentiation [inference]

regulation of regulatory T cell differentiation

regulation of T cell activation [inference]

regulation of T cell differentiation [inference]

regulation of regulatory T cell differentiation

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

regulation of lymphocyte activation [inference]

regulation of lymphocyte differentiation [inference]

regulation of T cell differentiation [inference]

regulation of regulatory T cell differentiation

regulation of T cell activation [inference]

regulation of T cell differentiation [inference]

regulation of regulatory T cell differentiation

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

regulation of lymphocyte differentiation [inference]

regulation of T cell differentiation [inference]

regulation of regulatory T cell differentiation

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
nucleus	EXP
nucleus	IBA
nucleus	IEA
nucleoplasm	TAS
nucleoplasm	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

microprocessor complex

intracellular protein-containing complex [inference]

endonuclease complex [inference]

endoribonuclease complex [inference]

ribonuclease III complex [inference]

microprocessor complex

catalytic complex [inference]

endonuclease complex [inference]

endoribonuclease complex [inference]

ribonuclease III complex [inference]

microprocessor complex

cellular anatomical structure [inference]

cell junction [inference]

synapse [inference]

glutamatergic synapse

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

membraneless organelle [inference]

intracellular membraneless organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular membraneless organelle [inference]

nucleolus

postsynaptic specialization [inference]

postsynaptic density

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
lipopolysaccharide binding	IDA
RNA binding	IPI
RNA binding	IEA
RNA binding	HDA
RNA endonuclease activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism [inference]

ribonuclease III activity

double-stranded RNA-specific ribonuclease activity [inference]

ribonuclease III activity

catalytic activity, acting on a nucleic acid [inference]

nuclease activity [inference]

endonuclease activity [inference]

RNA endonuclease activity

RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism [inference]

ribonuclease III activity

RNA nuclease activity [inference]

RNA endonuclease activity

RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism [inference]

ribonuclease III activity

double-stranded RNA-specific ribonuclease activity [inference]

ribonuclease III activity

catalytic activity, acting on RNA [inference]

RNA nuclease activity [inference]

RNA endonuclease activity

RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism [inference]

ribonuclease III activity

double-stranded RNA-specific ribonuclease activity [inference]

ribonuclease III activity

binding [inference]

nucleic acid binding [inference]

primary miRNA binding

protein binding

enzyme binding [inference]

DEAD/H-box RNA helicase binding

identical protein binding [inference]

protein homodimerization activity

R-SMAD binding

protein dimerization activity [inference]

protein homodimerization activity

lipid binding [inference]

lipopolysaccharide binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

carbohydrate derivative binding [inference]

lipopolysaccharide binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Ribonuclease

Functional Category

K: Transcription
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
RNA endonuclease activity
U4 snRNA 3'-end processing
double-stranded RNA binding
endonuclease activity
hydrolase activity
nuclease activity
pre-miRNA processing
ribonuclease III activity

Displaying **all 5** entries
InterPro
Double-stranded RNA-binding domain
RNase III, double-stranded RNA binding domain, animal
Ribonuclease III domain
Ribonuclease III, endonuclease domain superfamily
Ribonuclease III

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026