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Rac GTPase activating protein 1

Summary

Gene Symbol

RACGAP1

Organism

Homo sapiens (human)

External Links

NCBI Gene

29127

KEGG Gene ID

PubChem

29127

Alliance of Genome Resources

HGNC:9804

Annotation

Keyword

3D-structure
Acetylation
Cell division
Cell membrane
Coiled coil
Congenital dyserythropoietic anemia
Cytoplasmic vesicle
Cytoskeleton
Developmental protein
Disease variant
GTPase activation
Ion transport
Isopeptide bond
Lipid-binding
Microtubule
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Spermatogenesis
Ubl conjugation
Zinc-finger

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9H0H5	Male germ cell RacGap Protein CYK4 homolog
B2RE34	Male germ cell RacGap

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	PMID
mitotic cytokinesis	IC
mitotic cytokinesis	IDA
mitotic cytokinesis	IMP
mitotic cytokinesis	IBA
actomyosin contractile ring assembly	IMP

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

spindle midzone assembly [inference]

mitotic spindle midzone assembly

signal transduction

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

small GTPase-mediated signal transduction [inference]

Rho protein signal transduction

cell population proliferation [inference]

neural precursor cell proliferation [inference]

neuroblast proliferation

cell cycle process [inference]

cytokinesis [inference]

cytoskeleton-dependent cytokinesis [inference]

mitotic cytokinesis

cytokinetic process [inference]

assembly of actomyosin apparatus involved in cytokinesis [inference]

actomyosin contractile ring assembly

actomyosin contractile ring organization [inference]

actomyosin contractile ring assembly

spindle midzone assembly [inference]

mitotic spindle midzone assembly

mitotic cell cycle process [inference]

actin filament-based process [inference]

actin cytoskeleton organization [inference]

cortical actin cytoskeleton organization [inference]

actomyosin contractile ring organization [inference]

actomyosin contractile ring assembly

actomyosin structure organization [inference]

actomyosin contractile ring organization [inference]

actomyosin contractile ring assembly

cellular developmental process [inference]

cell differentiation

myeloid cell differentiation [inference]

erythrocyte differentiation

cell division

transmembrane transport [inference]

sulfate transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization [inference]

cortical actin cytoskeleton organization [inference]

actomyosin contractile ring organization [inference]

actomyosin contractile ring assembly

actomyosin structure organization [inference]

actomyosin contractile ring organization [inference]

actomyosin contractile ring assembly

cortical cytoskeleton organization [inference]

cortical actin cytoskeleton organization [inference]

actomyosin contractile ring organization [inference]

actomyosin contractile ring assembly

cellular component assembly [inference]

assembly of actomyosin apparatus involved in cytokinesis [inference]

actomyosin contractile ring assembly

spindle midzone assembly [inference]

mitotic spindle midzone assembly

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

developmental process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

cellular developmental process [inference]

cell differentiation

myeloid cell differentiation [inference]

erythrocyte differentiation

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport

inorganic anion transport [inference]

sulfate transmembrane transport

transmembrane transport [inference]

sulfate transmembrane transport

sulfur compound transport [inference]

sulfate transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of cytokinesis

positive regulation of cell division [inference]

positive regulation of cytokinesis

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction

regulation of developmental process [inference]

regulation of multicellular organismal development [inference]

regulation of embryonic development

regulation of cellular process [inference]

signal transduction

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

small GTPase-mediated signal transduction [inference]

Rho protein signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of cytokinesis

positive regulation of cell division [inference]

positive regulation of cytokinesis

regulation of cell division [inference]

regulation of cytokinesis [inference]

positive regulation of cytokinesis

positive regulation of cell division [inference]

positive regulation of cytokinesis

regulation of cell cycle [inference]

regulation of cell cycle process [inference]

regulation of cytokinesis [inference]

positive regulation of cytokinesis

regulation of attachment of spindle microtubules to kinetochore

positive regulation of cell cycle process [inference]

positive regulation of cytokinesis

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of cytokinesis

regulation of multicellular organismal process [inference]

regulation of multicellular organismal development [inference]

regulation of embryonic development

Displaying entries **1 - 5** of 27 in total

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GO Term	Evidence Code	PMID
acrosomal vesicle	IEA
nucleus	IDA
nucleus	IBA
nucleus	IEA
nucleoplasm	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

intracellular protein-containing complex [inference]

centralspindlin complex

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

cleavage furrow

midbody

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

membraneless organelle [inference]

intracellular membraneless organelle [inference]

spindle

mitotic spindle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

intracellular membraneless organelle [inference]

spindle

mitotic spindle

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of plasma membrane

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
GTPase activator activity	TAS
GTPase activator activity	IDA
GTPase activator activity	IMP
GTPase activator activity	IBA
GTPase activator activity	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

tubulin binding [inference]

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

lipid binding

phospholipid binding [inference]

phosphatidylinositol phosphate binding [inference]

phosphatidylinositol-3,4,5-trisphosphate binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

phosphatidylinositol-3,4,5-trisphosphate binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

GTPase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:1338	congenital dyserythropoietic anemia	Alliance of Genome Resources

Ortholog

Displaying 1 entry
Species	Gene ID	Alliance of Genome Resources
Mus musculus	26934	MGI:1349423

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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