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aquaporin 8

Summary

Gene Symbol

Aqp8

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

29172

KEGG Gene ID

PubChem

29172

Alliance of Genome Resources

RGD:2146

Annotation

Keyword

Cell membrane
Endoplasmic reticulum
Glycoprotein
Mitochondrion inner membrane
Oxidation
Porin
Reference proteome
Repeat
Transmembrane helix
Transport

Proteins

Displaying **all 3** entries
UniProt	Protein Name
P56405
A0A0H2UHM1
A6I904

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
water transport	ISO
water transport	NAS
water transport	IDA
water transport	IMP
water transport	IBA

GO Hierarchy

biological process

immune system process [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

B cell differentiation

B cell activation [inference]

B cell differentiation

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

B cell differentiation

B cell activation [inference]

B cell differentiation

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

B cell differentiation

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to cAMP

cellular response to oxygen-containing compound [inference]

cellular response to cAMP

transmembrane transport

urea transmembrane transport

ammonium transmembrane transport

ammonium import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

ammonium import across plasma membrane

cellular detoxification

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

B cell differentiation

B cell activation [inference]

B cell differentiation

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

B cell differentiation

response to stimulus [inference]

response to chemical [inference]

response to organophosphorus [inference]

response to cAMP [inference]

cellular response to cAMP

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to cAMP

cellular response to oxygen-containing compound [inference]

cellular response to cAMP

response to nitrogen compound [inference]

response to purine-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

cellular response to nitrogen compound [inference]

cellular response to cAMP

response to oxygen-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

cellular response to oxygen-containing compound [inference]

cellular response to cAMP

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to cAMP

cellular response to oxygen-containing compound [inference]

cellular response to cAMP

localization [inference]

establishment of localization [inference]

transport [inference]

lipid transport [inference]

bile acid and bile salt transport [inference]

canalicular bile acid transport

organic cation transport [inference]

methylammonium transport

methylammonium transmembrane transport

organic anion transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

bile acid and bile salt transport [inference]

canalicular bile acid transport

organic acid transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

bile acid and bile salt transport [inference]

canalicular bile acid transport

organic hydroxy compound transport [inference]

bile acid and bile salt transport [inference]

canalicular bile acid transport

one-carbon compound transport

urea transport

urea transmembrane transport

methylammonium transport

methylammonium transmembrane transport

fluid transport [inference]

water transport

transepithelial water transport

epithelial fluid transport [inference]

transepithelial water transport

secretion [inference]

canalicular bile acid transport

transmembrane transport

urea transmembrane transport

ammonium transmembrane transport

ammonium import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

ammonium import across plasma membrane

transepithelial transport [inference]

epithelial fluid transport [inference]

transepithelial water transport

nitrogen compound transport [inference]

amine transport [inference]

methylammonium transport

methylammonium transmembrane transport

urea transport

urea transmembrane transport

ammonium transmembrane transport

ammonium import across plasma membrane

import into cell [inference]

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

ammonium import across plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of lipid biosynthetic process [inference]

regulation of steroid biosynthetic process [inference]

regulation of sterol biosynthetic process [inference]

regulation of cholesterol biosynthetic process

regulation of alcohol biosynthetic process [inference]

regulation of cholesterol biosynthetic process

regulation of small molecule metabolic process [inference]

regulation of cholesterol metabolic process [inference]

regulation of cholesterol biosynthetic process

regulation of alcohol biosynthetic process [inference]

regulation of cholesterol biosynthetic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of steroid metabolic process [inference]

regulation of steroid biosynthetic process [inference]

regulation of sterol biosynthetic process [inference]

regulation of cholesterol biosynthetic process

regulation of cholesterol metabolic process [inference]

regulation of cholesterol biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of steroid biosynthetic process [inference]

regulation of sterol biosynthetic process [inference]

regulation of cholesterol biosynthetic process

detoxification [inference]

cellular detoxification

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GO Term	Evidence Code	PMID
mitochondrial inner membrane	IEA
smooth endoplasmic reticulum	ISS
smooth endoplasmic reticulum	ISO
plasma membrane	ISO
plasma membrane	EXP

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

pore complex

cellular anatomical structure [inference]

membrane

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane [inference]

smooth endoplasmic reticulum membrane

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane

mitochondrial inner membrane

bounding membrane of organelle [inference]

smooth endoplasmic reticulum membrane

plasma membrane region [inference]

cell projection membrane [inference]

brush border membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle

intracellular membrane-bounded organelle [inference]

mitochondrion

endoplasmic reticulum [inference]

smooth endoplasmic reticulum

intracellular vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

endoplasmic reticulum [inference]

smooth endoplasmic reticulum

intracellular vesicle

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
ammonium channel activity	ISS
ammonium channel activity	ISO
ammonium channel activity	IDA
ammonium channel activity	IEA
water channel activity	ISO

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

amine transmembrane transporter activity [inference]

methylammonium transmembrane transporter activity [inference]

methylammonium channel activity

water transmembrane transporter activity [inference]

water channel activity

urea transmembrane transporter activity [inference]

urea channel activity

passive transmembrane transporter activity [inference]

channel activity

wide pore channel activity [inference]

porin activity

Gene Ontology information from NCBI Gene and UniProt.

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
intracellular canaliculus	PMID:11932260

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	11833	MGI:1195271
Homo sapiens	343	HGNC:642

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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