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C-X-C motif chemokine receptor 2

Summary

Gene Symbol

Cxcr2

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

29385

PubChem

29385

Alliance of Genome Resources

RGD:2906

Annotation

Keyword

Cell membrane
Chemotaxis
Disulfide bond
G-protein coupled receptor
Glycoprotein
Phosphoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A6JVS7	High affinity interleukin-8 receptor B
P35407	GRO/MGSA receptor High affinity interleukin-8 receptor B

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 27 in total

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GO Term	Evidence Code	PMID
acute inflammatory response to antigenic stimulus	IMP	15516486
positive regulation of leukocyte chemotaxis	IMP	17717298
chemotaxis	ISO
immune response	IBA
cellular defense response	ISO

GO Hierarchy

biological process

immune system process [inference]

immune response

inflammatory response to antigenic stimulus [inference]

acute inflammatory response to antigenic stimulus

leukocyte activation [inference]

myeloid leukocyte activation [inference]

granulocyte activation [inference]

neutrophil activation

leukocyte migration [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

myeloid leukocyte migration [inference]

granulocyte migration [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

neutrophil migration [inference]

neutrophil chemotaxis

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

myeloid leukocyte activation [inference]

granulocyte activation [inference]

neutrophil activation

signal transduction [inference]

cell surface receptor signaling pathway

cytokine-mediated signaling pathway [inference]

G protein-coupled receptor signaling pathway [inference]

phospholipase C-activating G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

cell motility [inference]

cell migration [inference]

leukocyte migration [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

myeloid leukocyte migration [inference]

granulocyte migration [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

neutrophil migration [inference]

neutrophil chemotaxis

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

myeloid leukocyte activation [inference]

granulocyte activation [inference]

neutrophil activation

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

regulation of vascular permeability [inference]

positive regulation of vascular permeability

developmental process [inference]

anatomical structure morphogenesis [inference]

tube morphogenesis [inference]

epithelial tube morphogenesis [inference]

metanephric tubule morphogenesis

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

epithelial tube morphogenesis [inference]

metanephric tubule morphogenesis

anatomical structure development [inference]

midbrain development

locomotion [inference]

taxis [inference]

chemotaxis

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response [inference]

inflammatory response to antigenic stimulus [inference]

acute inflammatory response to antigenic stimulus

acute inflammatory response [inference]

acute inflammatory response to antigenic stimulus

cellular defense response

immune response

inflammatory response to antigenic stimulus [inference]

acute inflammatory response to antigenic stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

positive regulation of neutrophil migration [inference]

positive regulation of neutrophil chemotaxis

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

positive regulation of neutrophil migration [inference]

positive regulation of neutrophil chemotaxis

regulation of leukocyte chemotaxis [inference]

positive regulation of leukocyte chemotaxis

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

regulation of granulocyte chemotaxis [inference]

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

regulation of neutrophil chemotaxis [inference]

positive regulation of neutrophil chemotaxis

regulation of neutrophil migration [inference]

regulation of neutrophil chemotaxis [inference]

positive regulation of neutrophil chemotaxis

positive regulation of neutrophil migration [inference]

positive regulation of neutrophil chemotaxis

regulation of neutrophil apoptotic process [inference]

negative regulation of neutrophil apoptotic process

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

positive regulation of neutrophil migration [inference]

positive regulation of neutrophil chemotaxis

regulation of chemotaxis [inference]

regulation of leukocyte chemotaxis [inference]

positive regulation of leukocyte chemotaxis

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

regulation of granulocyte chemotaxis [inference]

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

regulation of neutrophil chemotaxis [inference]

positive regulation of neutrophil chemotaxis

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

positive regulation of neutrophil migration [inference]

positive regulation of neutrophil chemotaxis

regulation of leukocyte chemotaxis [inference]

positive regulation of leukocyte chemotaxis

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

regulation of granulocyte chemotaxis [inference]

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

regulation of neutrophil chemotaxis [inference]

positive regulation of neutrophil chemotaxis

regulation of neutrophil migration [inference]

regulation of neutrophil chemotaxis [inference]

positive regulation of neutrophil chemotaxis

positive regulation of neutrophil migration [inference]

positive regulation of neutrophil chemotaxis

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

positive regulation of neutrophil migration [inference]

positive regulation of neutrophil chemotaxis

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

positive regulation of neutrophil migration [inference]

positive regulation of neutrophil chemotaxis

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

positive regulation of neutrophil migration [inference]

positive regulation of neutrophil chemotaxis

positive regulation of locomotion [inference]

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

positive regulation of neutrophil migration [inference]

positive regulation of neutrophil chemotaxis

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of muscle cell apoptotic process [inference]

positive regulation of striated muscle cell apoptotic process [inference]

positive regulation of cardiac muscle cell apoptotic process

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

positive regulation of neutrophil migration [inference]

positive regulation of neutrophil chemotaxis

positive regulation of response to stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of myeloid cell apoptotic process [inference]

negative regulation of neutrophil apoptotic process

negative regulation of leukocyte apoptotic process [inference]

negative regulation of neutrophil apoptotic process

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

regulation of chemotaxis [inference]

regulation of leukocyte chemotaxis [inference]

positive regulation of leukocyte chemotaxis

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

regulation of granulocyte chemotaxis [inference]

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

regulation of neutrophil chemotaxis [inference]

positive regulation of neutrophil chemotaxis

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

positive regulation of response to stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

cytokine-mediated signaling pathway [inference]

G protein-coupled receptor signaling pathway [inference]

phospholipase C-activating G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

regulation of muscle cell apoptotic process [inference]

positive regulation of muscle cell apoptotic process [inference]

positive regulation of striated muscle cell apoptotic process [inference]

positive regulation of cardiac muscle cell apoptotic process

regulation of striated muscle cell apoptotic process [inference]

positive regulation of striated muscle cell apoptotic process [inference]

positive regulation of cardiac muscle cell apoptotic process

regulation of cardiac muscle cell apoptotic process [inference]

positive regulation of cardiac muscle cell apoptotic process

regulation of myeloid cell apoptotic process [inference]

regulation of neutrophil apoptotic process [inference]

negative regulation of neutrophil apoptotic process

negative regulation of myeloid cell apoptotic process [inference]

negative regulation of neutrophil apoptotic process

positive regulation of apoptotic process [inference]

positive regulation of muscle cell apoptotic process [inference]

positive regulation of striated muscle cell apoptotic process [inference]

positive regulation of cardiac muscle cell apoptotic process

negative regulation of apoptotic process

negative regulation of myeloid cell apoptotic process [inference]

negative regulation of neutrophil apoptotic process

negative regulation of leukocyte apoptotic process [inference]

negative regulation of neutrophil apoptotic process

regulation of leukocyte apoptotic process [inference]

regulation of neutrophil apoptotic process [inference]

negative regulation of neutrophil apoptotic process

negative regulation of leukocyte apoptotic process [inference]

negative regulation of neutrophil apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of muscle cell apoptotic process [inference]

positive regulation of striated muscle cell apoptotic process [inference]

positive regulation of cardiac muscle cell apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of myeloid cell apoptotic process [inference]

negative regulation of neutrophil apoptotic process

negative regulation of leukocyte apoptotic process [inference]

negative regulation of neutrophil apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of muscle cell apoptotic process [inference]

positive regulation of striated muscle cell apoptotic process [inference]

positive regulation of cardiac muscle cell apoptotic process

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

positive regulation of neutrophil migration [inference]

positive regulation of neutrophil chemotaxis

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of myeloid cell apoptotic process [inference]

negative regulation of neutrophil apoptotic process

negative regulation of leukocyte apoptotic process [inference]

negative regulation of neutrophil apoptotic process

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

positive regulation of neutrophil migration [inference]

positive regulation of neutrophil chemotaxis

regulation of leukocyte chemotaxis [inference]

positive regulation of leukocyte chemotaxis

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

regulation of granulocyte chemotaxis [inference]

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

regulation of neutrophil chemotaxis [inference]

positive regulation of neutrophil chemotaxis

regulation of neutrophil migration [inference]

regulation of neutrophil chemotaxis [inference]

positive regulation of neutrophil chemotaxis

positive regulation of neutrophil migration [inference]

positive regulation of neutrophil chemotaxis

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

positive regulation of neutrophil migration [inference]

positive regulation of neutrophil chemotaxis

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

positive regulation of neutrophil migration [inference]

positive regulation of neutrophil chemotaxis

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of biological quality [inference]

positive regulation of cytosolic calcium ion concentration

regulation of vascular permeability [inference]

positive regulation of vascular permeability

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
nucleoplasm	ISO
nucleoplasm	IEA
plasma membrane	ISO
external side of plasma membrane	IBA
cell surface	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome [inference]

mast cell granule

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

spindle [inference]

mitotic spindle

cytoskeleton [inference]

microtubule cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome [inference]

mast cell granule

intracellular non-membrane-bounded organelle [inference]

spindle [inference]

mitotic spindle

cytoskeleton [inference]

microtubule cytoskeleton

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
interleukin-8 receptor activity	ISO
G protein-coupled receptor activity	ISO
chemokine receptor activity	ISO
C-C chemokine receptor activity	IBA
C-X-C chemokine receptor activity	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

cytokine binding [inference]

chemokine binding [inference]

C-C chemokine binding

C-X-C chemokine binding [inference]

interleukin-8 binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

cytokine receptor activity [inference]

chemokine receptor activity

C-C chemokine receptor activity

C-X-C chemokine receptor activity

interleukin-8 receptor activity

G protein-coupled receptor activity

G protein-coupled chemoattractant receptor activity [inference]

chemokine receptor activity

C-C chemokine receptor activity

C-X-C chemokine receptor activity

interleukin-8 receptor activity

immune receptor activity [inference]

cytokine receptor activity [inference]

chemokine receptor activity

C-C chemokine receptor activity

C-X-C chemokine receptor activity

interleukin-8 receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

receptor 2

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
C-C chemokine binding
C-C chemokine receptor activity
calcium-mediated signaling
chemokine-mediated signaling pathway
chemotaxis
immune response
neutrophil chemotaxis
positive regulation of cytosolic calcium ion concentration

Displaying **all 2** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0060180	colitis	Alliance of Genome Resources
DOID:10952	nephritis	Alliance of Genome Resources
DOID:3213	demyelinating disease	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of **142** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	60628	WB:WBGene00011578
Caenorhabditis elegans	80901	WB:WBGene00011578
Caenorhabditis elegans	84475	WB:WBGene00011578
Caenorhabditis elegans	117029	WB:WBGene00011578
Danio rerio	227288	ZFIN:ZDB-GENE-100414-1
Caenorhabditis elegans	252837	WB:WBGene00011578
Bos taurus	281863		BOVIN24739
Pan troglodytes	470644		PANTR29751
Pan troglodytes	470645		PANTR29752
Canis lupus familiaris	478905		CANLF14212

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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OrthoDB (Group)

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Acknowledgements