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sodium voltage-gated channel alpha subunit 8

Summary

Gene Symbol

Scn8a

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

29710

KEGG Gene ID

PubChem

29710

Alliance of Genome Resources

RGD:3638

Annotation

Keyword

Alternative splicing
Cell membrane
Cell projection
Disulfide bond
Glycoprotein
Metal-binding
Phosphoprotein
Reference proteome
Repeat
Sodium channel
Transmembrane helix
Ubl conjugation
Voltage-gated channel

Proteins

Displaying **all 3** entries
UniProt	Protein Name
F1LMH2
O88420	Peripheral nerve protein type 4 Sodium channel 6 Sodium channel protein type VIII subunit alpha Voltage-gated sodium channel subunit alpha Nav1.6
A0A8I5ZX68

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 24 in total

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GO Term	Evidence Code	PMID
action potential	ISO
action potential	IEA
monoatomic ion transport	IEA
ion transport	IEA
sodium ion transport	IDA

GO Hierarchy

biological process

cellular process [inference]

ensheathment of neurons [inference]

axon ensheathment [inference]

myelination

transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of pain

sensory perception of mechanical stimulus [inference]

sensory perception of sound

behavior [inference]

locomotory behavior

adult locomotory behavior [inference]

adult walking behavior

walking behavior [inference]

adult walking behavior

adult behavior [inference]

adult locomotory behavior [inference]

adult walking behavior

developmental process [inference]

anatomical structure development [inference]

nerve development

cranial nerve development [inference]

optic nerve development

animal organ development [inference]

muscle organ development

system development [inference]

peripheral nervous system development

muscle structure development [inference]

muscle organ development

response to stimulus [inference]

response to chemical [inference]

response to toxic substance

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport

sodium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

biological regulation [inference]

regulation of biological quality [inference]

regulation of membrane potential [inference]

action potential

neuronal action potential

membrane depolarization [inference]

membrane depolarization during action potential

Displaying entries **1 - 5** of 24 in total

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GO Term	Evidence Code	PMID
voltage-gated sodium channel complex	ISO
voltage-gated sodium channel complex	IBA
voltage-gated sodium channel complex	IEA
plasma membrane	ISO
plasma membrane	EXP

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

voltage-gated sodium channel complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

sodium channel complex

voltage-gated sodium channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

sodium channel complex

voltage-gated sodium channel complex

cellular anatomical structure [inference]

membrane

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic active zone membrane

postsynaptic specialization membrane [inference]

postsynaptic density membrane

Z disc

cell junction

synapse [inference]

excitatory synapse [inference]

parallel fiber to Purkinje cell synapse

glutamatergic synapse

node of Ranvier

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon initial segment

cell body [inference]

neuronal cell body

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
ion channel activity	IEA
monoatomic ion channel activity	IEA
voltage-gated sodium channel activity	ISO
voltage-gated sodium channel activity	IC
voltage-gated sodium channel activity	IDA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity

monoatomic cation channel activity

sodium channel activity [inference]

voltage-gated sodium channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity

sodium channel activity [inference]

voltage-gated sodium channel activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity

monoatomic cation channel activity

sodium channel activity [inference]

voltage-gated sodium channel activity

binding [inference]

protein binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

alkali metal ion binding [inference]

sodium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

sodium channel protein

Functional Category

E: Amino acid transport and metabolism
K: Transcription
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
membrane depolarization during action potential
monoatomic ion channel activity
monoatomic ion transport
neuronal action potential
sodium channel activity
sodium ion transmembrane transport
voltage-gated sodium channel activity

Displaying **all 7** entries
InterPro
Ion transport domain
Sodium ion transport-associated domain
Voltage gated sodium channel, alpha subunit
Voltage-dependent channel domain superfamily
Voltage-gated Na+ ion channel, cytoplasmic domain
Voltage-gated cation channel calcium and sodium
Voltage-gated sodium channel alpha subunit, inactivation gate

Ortholog

Displaying **all 3** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	20273	MGI:103169
Drosophila melanogaster	32619	FB:FBgn0285944
Homo sapiens	6334	HGNC:10596

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements