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Guidelines

MIRAGE

sphingosine-1-phosphate receptor 1

Summary

Gene Symbol

S1pr1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

29733

KEGG Gene ID

PubChem

29733

Alliance of Genome Resources

RGD:61958

Annotation

Keyword

Acetylation
Angiogenesis
Cell membrane
Chemotaxis
Disulfide bond
Endosome
G-protein coupled receptor
Glycoprotein
Palmitate
Phosphoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P48303	Endothelial differentiation G-protein coupled receptor 1 Sphingosine 1-phosphate receptor Edg-1
A6HV78	Sphingosine 1-phosphate receptor Edg-1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 57 in total

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GO Term	Evidence Code	PMID
angiogenesis	ISO
angiogenesis	IBA
blood vessel maturation	ISS
blood vessel maturation	ISO
blood vessel maturation	IEA

GO Hierarchy

biological process

immune system process [inference]

leukocyte migration [inference]

leukocyte chemotaxis

mononuclear cell migration [inference]

lymphocyte migration [inference]

T cell migration

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

sphingosine-1-phosphate receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

phospholipase C-activating G protein-coupled receptor signaling pathway

sphingolipid mediated signaling pathway [inference]

sphingosine-1-phosphate receptor signaling pathway

cell population proliferation

actin filament-based process [inference]

actin cytoskeleton organization

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation

epithelial cell differentiation [inference]

endothelial cell differentiation

cell motility [inference]

leukocyte migration [inference]

leukocyte chemotaxis

mononuclear cell migration [inference]

lymphocyte migration [inference]

T cell migration

cell chemotaxis [inference]

leukocyte chemotaxis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly

plasma membrane bounded cell projection organization [inference]

lamellipodium organization [inference]

lamellipodium assembly

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

transmission of nerve impulse

developmental process [inference]

anatomical structure morphogenesis [inference]

trabecula morphogenesis [inference]

heart trabecula morphogenesis

developmental maturation [inference]

anatomical structure maturation [inference]

blood vessel maturation

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

anatomical structure development [inference]

animal organ development [inference]

brain development

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation

epithelial cell differentiation [inference]

endothelial cell differentiation

growth [inference]

developmental growth [inference]

cardiac muscle tissue growth [inference]

cardiac muscle tissue growth involved in heart morphogenesis

developmental growth involved in morphogenesis [inference]

growth involved in heart morphogenesis [inference]

cardiac muscle tissue growth involved in heart morphogenesis

locomotion [inference]

taxis [inference]

cell chemotaxis [inference]

leukocyte chemotaxis

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of chemotaxis [inference]

positive regulation of positive chemotaxis

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of chemotaxis [inference]

positive regulation of chemotaxis [inference]

positive regulation of positive chemotaxis

regulation of positive chemotaxis [inference]

positive regulation of positive chemotaxis

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of chemotaxis [inference]

positive regulation of positive chemotaxis

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of smooth muscle cell proliferation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of response to stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis [inference]

positive regulation of positive chemotaxis

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis [inference]

positive regulation of positive chemotaxis

regulation of chemotaxis [inference]

positive regulation of chemotaxis [inference]

positive regulation of positive chemotaxis

regulation of positive chemotaxis [inference]

positive regulation of positive chemotaxis

positive regulation of response to stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis [inference]

positive regulation of positive chemotaxis

regulation of developmental process [inference]

regulation of multicellular organismal development [inference]

regulation of biomineral tissue development [inference]

regulation of bone mineralization

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

sphingosine-1-phosphate receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

phospholipase C-activating G protein-coupled receptor signaling pathway

sphingolipid mediated signaling pathway [inference]

sphingosine-1-phosphate receptor signaling pathway

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of cell adhesion

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actomyosin structure organization [inference]

regulation of stress fiber assembly [inference]

negative regulation of stress fiber assembly

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of stress fiber assembly [inference]

negative regulation of stress fiber assembly

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of smooth muscle cell proliferation

regulation of smooth muscle cell proliferation [inference]

positive regulation of smooth muscle cell proliferation

regulation of cellular component biogenesis [inference]

regulation of actin filament bundle assembly [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of stress fiber assembly [inference]

negative regulation of stress fiber assembly

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of smooth muscle cell proliferation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of cell motility [inference]

positive regulation of cell migration

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actomyosin structure organization [inference]

regulation of stress fiber assembly [inference]

negative regulation of stress fiber assembly

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of stress fiber assembly [inference]

negative regulation of stress fiber assembly

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of supramolecular fiber organization [inference]

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of stress fiber assembly [inference]

negative regulation of stress fiber assembly

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of multicellular organismal process [inference]

regulation of ossification [inference]

regulation of bone mineralization

regulation of tissue remodeling [inference]

regulation of bone remodeling [inference]

regulation of bone resorption

regulation of multicellular organismal development [inference]

regulation of biomineral tissue development [inference]

regulation of bone mineralization

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity

regulation of hydrolase activity [inference]

regulation of GTPase activity [inference]

positive regulation of GTPase activity

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
nucleoplasm
cytoplasm	IBA
endosome	ISS
endosome	IEA
plasma membrane	ISS

GO Hierarchy

cellular component

cellular anatomical structure [inference]

plasma membrane

membrane microdomain [inference]

membrane raft

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

side of membrane [inference]

external side of plasma membrane

presynapse

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
G protein-coupled receptor binding	ISO
G protein-coupled receptor binding	IEA
G protein-coupled receptor activity	TAS
G protein-coupled receptor activity	IMP
G protein-coupled receptor activity	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

G protein-coupled receptor binding

lipid binding [inference]

sphingolipid binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

bioactive lipid receptor activity [inference]

sphingosine-1-phosphate receptor activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:10763	hypertension	Alliance of Genome Resources

Ortholog

Displaying **all 3** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	13609	MGI:1096355
Homo sapiens	1901	HGNC:3165
Danio rerio	64617	ZFIN:ZDB-GENE-001228-2

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026