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dihydrolipoamide dehydrogenase

Summary

Gene Symbol

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

298942

KEGG Gene ID

PubChem

298942

Alliance of Genome Resources

RGD:735073

Annotation

Keyword

Acetylation
Cytoplasmic vesicle
Direct protein sequencing
Disulfide bond
FAD
Flagellum
Mitochondrion
NAD
Nucleotide-binding
Nucleus
Oxidoreductase
Phosphoprotein
Proteomics identification
Redox-active center
Reference proteome
Transit peptide

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A6HB44
Q6P6R2	Dihydrolipoamide dehydrogenase
A0A8I5ZXS2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
pyruvate decarboxylation to acetyl-CoA	ISO
pyruvate decarboxylation to acetyl-CoA	IDA
pyruvate decarboxylation to acetyl-CoA	IEA
pyruvate metabolic process	IBA
tricarboxylic acid cycle	ISO

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

cellular respiration [inference]

aerobic respiration [inference]

aerobic electron transport chain [inference]

mitochondrial electron transport, NADH to ubiquinone

electron transport chain [inference]

respiratory electron transport chain [inference]

aerobic electron transport chain [inference]

mitochondrial electron transport, NADH to ubiquinone

sulfur compound metabolic process [inference]

acyl-CoA metabolic process [inference]

acetyl-CoA metabolic process [inference]

acetyl-CoA biosynthetic process [inference]

pyruvate decarboxylation to acetyl-CoA

succinyl-CoA metabolic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

fatty-acyl-CoA metabolic process [inference]

branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA

acyl-CoA biosynthetic process [inference]

acetyl-CoA biosynthetic process [inference]

pyruvate decarboxylation to acetyl-CoA

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

lipoate metabolic process

sulfur compound biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

acetyl-CoA biosynthetic process [inference]

pyruvate decarboxylation to acetyl-CoA

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

dihydrolipoamide metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

acetyl-CoA metabolic process [inference]

acetyl-CoA biosynthetic process [inference]

pyruvate decarboxylation to acetyl-CoA

succinyl-CoA metabolic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

fatty-acyl-CoA metabolic process [inference]

branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA

acyl-CoA biosynthetic process [inference]

acetyl-CoA biosynthetic process [inference]

pyruvate decarboxylation to acetyl-CoA

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

nucleoside phosphate biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

acetyl-CoA biosynthetic process [inference]

pyruvate decarboxylation to acetyl-CoA

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

acetyl-CoA metabolic process [inference]

acetyl-CoA biosynthetic process [inference]

pyruvate decarboxylation to acetyl-CoA

succinyl-CoA metabolic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

fatty-acyl-CoA metabolic process [inference]

branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA

acyl-CoA biosynthetic process [inference]

acetyl-CoA biosynthetic process [inference]

pyruvate decarboxylation to acetyl-CoA

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

nucleoside phosphate biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

acetyl-CoA biosynthetic process [inference]

pyruvate decarboxylation to acetyl-CoA

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

organophosphate biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

acetyl-CoA biosynthetic process [inference]

pyruvate decarboxylation to acetyl-CoA

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

branched-chain amino acid catabolic process

biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

acetyl-CoA biosynthetic process [inference]

pyruvate decarboxylation to acetyl-CoA

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

sulfur compound biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

acetyl-CoA biosynthetic process [inference]

pyruvate decarboxylation to acetyl-CoA

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

purine-containing compound biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

acetyl-CoA biosynthetic process [inference]

pyruvate decarboxylation to acetyl-CoA

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

organophosphate biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

acetyl-CoA biosynthetic process [inference]

pyruvate decarboxylation to acetyl-CoA

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

primary metabolic process [inference]

tricarboxylic acid cycle

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

acetyl-CoA biosynthetic process [inference]

pyruvate decarboxylation to acetyl-CoA

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

acetyl-CoA metabolic process [inference]

acetyl-CoA biosynthetic process [inference]

pyruvate decarboxylation to acetyl-CoA

succinyl-CoA metabolic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

fatty-acyl-CoA metabolic process [inference]

branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA

acyl-CoA biosynthetic process [inference]

acetyl-CoA biosynthetic process [inference]

pyruvate decarboxylation to acetyl-CoA

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

nucleoside phosphate biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

acetyl-CoA biosynthetic process [inference]

pyruvate decarboxylation to acetyl-CoA

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process

branched-chain amino acid metabolic process [inference]

branched-chain amino acid catabolic process

lipid metabolic process [inference]

fatty acid metabolic process [inference]

lipoate metabolic process

fatty acid derivative metabolic process [inference]

fatty-acyl-CoA metabolic process [inference]

branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA

protein metabolic process [inference]

proteolysis

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

branched-chain amino acid catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

branched-chain amino acid metabolic process [inference]

branched-chain amino acid catabolic process

monocarboxylic acid metabolic process [inference]

pyruvate metabolic process

pyruvate decarboxylation to acetyl-CoA

fatty acid metabolic process [inference]

lipoate metabolic process

dicarboxylic acid metabolic process [inference]

2-oxoglutarate metabolic process

2-oxoglutarate decarboxylation to succinyl-CoA

carboxylic acid catabolic process [inference]

branched-chain amino acid catabolic process

branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

branched-chain amino acid catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

acetyl-CoA metabolic process [inference]

acetyl-CoA biosynthetic process [inference]

pyruvate decarboxylation to acetyl-CoA

succinyl-CoA metabolic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

fatty-acyl-CoA metabolic process [inference]

branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA

acyl-CoA biosynthetic process [inference]

acetyl-CoA biosynthetic process [inference]

pyruvate decarboxylation to acetyl-CoA

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

nucleoside phosphate biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

acetyl-CoA biosynthetic process [inference]

pyruvate decarboxylation to acetyl-CoA

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

purine-containing compound metabolic process [inference]

acyl-CoA metabolic process [inference]

acetyl-CoA metabolic process [inference]

acetyl-CoA biosynthetic process [inference]

pyruvate decarboxylation to acetyl-CoA

succinyl-CoA metabolic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

fatty-acyl-CoA metabolic process [inference]

branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA

acyl-CoA biosynthetic process [inference]

acetyl-CoA biosynthetic process [inference]

pyruvate decarboxylation to acetyl-CoA

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

purine-containing compound biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

acetyl-CoA biosynthetic process [inference]

pyruvate decarboxylation to acetyl-CoA

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

cellular process involved in reproduction in multicellular organism [inference]

sperm capacitation

cellular developmental process [inference]

cell maturation [inference]

sperm capacitation

reproductive process [inference]

developmental process involved in reproduction [inference]

sperm capacitation

multicellular organismal reproductive process [inference]

cellular process involved in reproduction in multicellular organism [inference]

sperm capacitation

developmental process [inference]

developmental process involved in reproduction [inference]

sperm capacitation

anatomical structure morphogenesis [inference]

embryonic morphogenesis [inference]

gastrulation

developmental maturation [inference]

anatomical structure maturation [inference]

cell maturation [inference]

sperm capacitation

cellular developmental process [inference]

cell maturation [inference]

sperm capacitation

biological regulation [inference]

regulation of biological quality [inference]

regulation of membrane potential

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	PMID
acrosomal vesicle	IEA
nucleus	ISS
nucleus	ISO
nucleus	IEA
nucleoplasm	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

tricarboxylic acid cycle heteromeric enzyme complex [inference]

oxoglutarate dehydrogenase complex

oxidoreductase complex [inference]

alpha-ketoacid dehydrogenase complex [inference]

transferase complex [inference]

acetyltransferase complex [inference]

pyruvate dehydrogenase complex

cellular anatomical structure [inference]

nucleoplasm

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium

motile cilium

acrosomal matrix

organelle [inference]

membrane-bounded organelle [inference]

cilium

motile cilium

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
dihydrolipoyl dehydrogenase (NADH) activity	ISS
dihydrolipoyl dehydrogenase (NADH) activity	ISO
dihydrolipoyl dehydrogenase (NADH) activity	IDA
dihydrolipoyl dehydrogenase (NADH) activity	IBA
dihydrolipoyl dehydrogenase (NADH) activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

oxidoreductase activity, acting on a sulfur group of donors [inference]

oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor

dihydrolipoyl dehydrogenase (NADH) activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

flavin adenine dinucleotide binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

flavin adenine dinucleotide binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

flavin adenine dinucleotide binding

sulfur compound binding [inference]

lipoamide binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Glutathione

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
cellular response to oxidative stress
flavin adenine dinucleotide binding
nucleotide binding
oxidoreductase activity

Displaying **all 6** entries
InterPro
FAD/NAD(P)-binding domain superfamily
FAD/NAD(P)-binding domain
FAD/NAD-linked reductase, dimerisation domain superfamily
Pyridine nucleotide-disulphide oxidoreductase, class I, active site
Pyridine nucleotide-disulphide oxidoreductase, class I
Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
pyruvate dehydrogenase complex	PMID:7487891
oxoglutarate dehydrogenase complex	PMID:3571202

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	13382	MGI:107450
Homo sapiens	1738	HGNC:2898

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements