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epsin 1

Summary

Gene Symbol

EPN1

Organism

Homo sapiens (human)

External Links

NCBI Gene

29924

KEGG Gene ID

PubChem

29924

Alliance of Genome Resources

HGNC:21604

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Coated pit
Cytoplasm
Endocytosis
Lipid-binding
Methylation
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9Y6I3	EH domain-binding mitotic phosphoprotein EPS-15-interacting protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
in utero embryonic development
endocytosis	TAS
endocytosis	IBA
Notch signaling pathway
female pregnancy

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

vesicle-mediated transport [inference]

endocytosis

reproductive process [inference]

multi-organism reproductive process [inference]

female pregnancy

multicellular organismal process [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

multi-multicellular organism process [inference]

female pregnancy

developmental process [inference]

anatomical structure development [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

animal organ development [inference]

embryonic organ development

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis

import into cell [inference]

endocytosis

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of developmental process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis [inference]

negative regulation of sprouting angiogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis [inference]

negative regulation of sprouting angiogenesis

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis [inference]

negative regulation of sprouting angiogenesis

regulation of sprouting angiogenesis [inference]

negative regulation of sprouting angiogenesis

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis [inference]

negative regulation of sprouting angiogenesis

negative regulation of developmental process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis [inference]

negative regulation of sprouting angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis [inference]

negative regulation of sprouting angiogenesis

regulation of sprouting angiogenesis [inference]

negative regulation of sprouting angiogenesis

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis [inference]

negative regulation of sprouting angiogenesis

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis [inference]

negative regulation of sprouting angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis [inference]

negative regulation of sprouting angiogenesis

regulation of sprouting angiogenesis [inference]

negative regulation of sprouting angiogenesis

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis [inference]

negative regulation of sprouting angiogenesis

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
nucleus	IEA
cytoplasm	IEA
endosome	IBA
cytosol	TAS
plasma membrane	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

membrane coat [inference]

clathrin coat [inference]

clathrin vesicle coat

vesicle coat [inference]

clathrin vesicle coat

cellular anatomical structure [inference]

membrane [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI
phospholipid binding	IBA
clathrin binding	IBA
molecular sequestering activity	EXP
molecular sequestering activity	IPI

GO Hierarchy

molecular function

binding [inference]

protein binding

clathrin binding

lipid binding [inference]

phospholipid binding

molecular sequestering activity

Gene Ontology information from NCBI Gene and UniProt.

Ortholog

Displaying 1 entry
Species	Gene ID	Alliance of Genome Resources
Mus musculus	13854	MGI:1333763

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026

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