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ALG6 alpha-1,3-glucosyltransferase

Summary

Gene Symbol

ALG6

Aliases

dolichyl-P-Glc:Man(9)GlcNAc(2)-PP-dolichol alpha- 1->3-glucosyltransferase

Organism

Homo sapiens (human)

External Links

NCBI Gene

29929

GGDB ID

gg146

HGNC

23157

mRNA

NM_013339

map

1p31.3

Protein

NP_037471

OMIM

604566

KEGG Gene ID

hsa:29929

PubChem

29929

Alliance of Genome Resources

HGNC:23157

JoGo

ALG6

TogoVar

ALG6

Annotation

Keyword

Congenital disorder of glycosylation
Disease variant
Endoplasmic reticulum
Glycoprotein
Glycosyltransferase
Proteomics identification
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9Y672	Asparagine-linked glycosylation protein 6 homolog Dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase Dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein N-linked glycosylation	IDA
protein N-linked glycosylation	IMP
dolichol-linked oligosaccharide biosynthetic process	TAS
dolichol-linked oligosaccharide biosynthetic process	IMP
dolichol-linked oligosaccharide biosynthetic process	IBA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein N-linked glycosylation

carbohydrate derivative biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

glycoprotein biosynthetic process [inference]

protein N-linked glycosylation

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein N-linked glycosylation

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

protein N-linked glycosylation

primary metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

protein N-linked glycosylation

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

protein N-linked glycosylation

carbohydrate derivative biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

glycoprotein biosynthetic process [inference]

protein N-linked glycosylation

Displaying **all 5** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	TAS
endoplasmic reticulum membrane	IBA
endoplasmic reticulum membrane	IEA
membrane	HDA
lumenal side of endoplasmic reticulum membrane	IC

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

side of membrane [inference]

lumenal side of membrane [inference]

lumenal side of endoplasmic reticulum membrane

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity	TAS
protein binding	IPI
hexosyltransferase activity	IEA
dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity	IMP
dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity	IGI

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

hexosyltransferase activity

glucosyltransferase activity

dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity

dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Alpha-1 3-glucosyltransferase

Functional Category

I: Lipid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity
hexosyltransferase activity
oligosaccharide-lipid intermediate biosynthetic process
protein N-linked glycosylation
transferase activity

Displaying 1 entry
InterPro
Glycosyl transferase, ALG6/ALG8

Human Protein Atlas

ENSG00000088035

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg146

Gene Symbol

ALG6

Reactions

Displaying 1 entry
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
Dol-P-Glc	G39578OU		G24620AI

Displaying 1 entry
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
Dol-P-Glc	G39578OU		G24620AI

Orthologous Gene

Displaying **all 6** entries
Species	Protein	mRNA
Caenorhabditis elegans	NP_495685	NM_063284
Mus musculus	NP_848899	NM_178784
Saccharomyces cerevisiae	CAA99190	Z74910
Drosophila melanogaster	NP_609393	NM_135549
Rattus norvegicus	XP_342869	XM_342868
Arabidopsis thaliana	NP_198662	NM_123207

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0080555	congenital disorder of glycosylation Ic	Glyco-Disease Genes Database Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 40 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000158	Macroglossia
HP:0000316	Hypertelorism
HP:0000369	Low-set ears
HP:0000486	Strabismus
HP:0000510	Rod-cone dystrophy
HP:0000546	Retinal degeneration
HP:0000707	Abnormality of the nervous system
HP:0000924	Abnormality of the skeletal system
HP:0000952	Jaundice