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ATP binding cassette subfamily A member 3

Summary

Gene Symbol

Abca3

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

302973

KEGG Gene ID

PubChem

302973

Alliance of Genome Resources

RGD:1307174

Annotation

Keyword

ATP-binding
Cytoplasmic vesicle
Disulfide bond
Endosome
Glycoprotein
Lipid transport
Lysosome
Reference proteome
Repeat
Translocase
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
A0A0G2K1Q8	ATP-binding cassette sub-family A member 3 Xenobiotic-transporting ATPase ABCA3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 47 in total

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GO Term	Evidence Code	PMID
xenobiotic transmembrane transport	ISS
xenobiotic transmembrane transport	ISO
xenobiotic transmembrane transport	IEA
lipid transport	IBA
positive regulation of cholesterol efflux	ISS

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

membrane organization [inference]

regulation of membrane lipid distribution [inference]

lipid translocation

export from cell [inference]

xenobiotic export from cell

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

surfactant homeostasis

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

lung development

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

surfactant homeostasis

chemical homeostasis [inference]

lipid homeostasis [inference]

phospholipid homeostasis

multicellular organismal-level chemical homeostasis [inference]

surfactant homeostasis

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to chemical [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to lipid [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

localization [inference]

establishment of localization [inference]

transport [inference]

lipid transport

organophosphate ester transport [inference]

phospholipid transport

xenobiotic transport

transmembrane transport

export from cell [inference]

xenobiotic export from cell

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of lipid transport

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

positive regulation of phospholipid transport

positive regulation of phospholipid efflux

regulation of sterol transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

regulation of cholesterol transport [inference]

regulation of cholesterol efflux [inference]

positive regulation of cholesterol efflux

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

regulation of phospholipid transport [inference]

regulation of phospholipid efflux [inference]

positive regulation of phospholipid efflux

positive regulation of phospholipid transport

positive regulation of phospholipid efflux

positive regulation of transport [inference]

positive regulation of vesicle fusion

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

positive regulation of phospholipid transport

positive regulation of phospholipid efflux

regulation of vesicle-mediated transport [inference]

regulation of vesicle fusion [inference]

positive regulation of vesicle fusion

regulation of lipid localization [inference]

regulation of lipid transport

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

positive regulation of phospholipid transport

positive regulation of phospholipid efflux

regulation of sterol transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

regulation of cholesterol transport [inference]

regulation of cholesterol efflux [inference]

positive regulation of cholesterol efflux

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

regulation of phospholipid transport [inference]

regulation of phospholipid efflux [inference]

positive regulation of phospholipid efflux

positive regulation of phospholipid transport

positive regulation of phospholipid efflux

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

positive regulation of phospholipid transport

positive regulation of phospholipid efflux

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein oligomerization [inference]

positive regulation of protein homooligomerization

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of vesicle fusion

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein oligomerization [inference]

positive regulation of protein homooligomerization

positive regulation of transport [inference]

positive regulation of vesicle fusion

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

positive regulation of phospholipid transport

positive regulation of phospholipid efflux

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

positive regulation of phospholipid transport

positive regulation of phospholipid efflux

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of lipid biosynthetic process

regulation of phosphorus metabolic process [inference]

regulation of phospholipid metabolic process [inference]

regulation of phosphatidylcholine metabolic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of lipid biosynthetic process

regulation of phospholipid metabolic process [inference]

regulation of phosphatidylcholine metabolic process

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein oligomerization [inference]

positive regulation of protein homooligomerization

regulation of protein oligomerization [inference]

positive regulation of protein oligomerization [inference]

positive regulation of protein homooligomerization

regulation of protein homooligomerization [inference]

positive regulation of protein homooligomerization

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein oligomerization [inference]

positive regulation of protein homooligomerization

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein oligomerization [inference]

positive regulation of protein homooligomerization

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of vesicle fusion

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein oligomerization [inference]

positive regulation of protein homooligomerization

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of vesicle fusion

regulation of vesicle fusion [inference]

positive regulation of vesicle fusion

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein oligomerization [inference]

positive regulation of protein homooligomerization

regulation of protein oligomerization [inference]

positive regulation of protein oligomerization [inference]

positive regulation of protein homooligomerization

regulation of protein homooligomerization [inference]

positive regulation of protein homooligomerization

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of vesicle fusion

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein oligomerization [inference]

positive regulation of protein homooligomerization

regulation of vesicle-mediated transport [inference]

regulation of vesicle fusion [inference]

positive regulation of vesicle fusion

regulation of biological quality [inference]

regulation of membrane lipid distribution [inference]

lipid translocation

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GO Term	Evidence Code	PMID
cytoplasm	IEA
lysosomal membrane	ISS
lysosomal membrane	ISO
lysosomal membrane	IEA
late endosome	ISS

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane

endosome membrane [inference]

late endosome membrane

multivesicular body membrane

secretory granule membrane [inference]

lamellar body membrane

alveolar lamellar body membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane [inference]

late endosome membrane

multivesicular body membrane

secretory granule membrane [inference]

lamellar body membrane

alveolar lamellar body membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

secretory vesicle [inference]

secretory granule [inference]

lamellar body

alveolar lamellar body

intracellular membrane-bounded organelle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

secretory vesicle [inference]

secretory granule [inference]

lamellar body

alveolar lamellar body

intracellular organelle [inference]

intracellular membrane-bounded organelle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

secretory vesicle [inference]

secretory granule [inference]

lamellar body

alveolar lamellar body

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
lipid carrier activity	IBA
ATP binding	IEA
ABC-type xenobiotic transporter activity	ISS
ABC-type xenobiotic transporter activity	ISO
ABC-type xenobiotic transporter activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity [inference]

transmembrane transporter activity [inference]

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity

ABC-type xenobiotic transporter activity

xenobiotic transmembrane transporter activity [inference]

ABC-type xenobiotic transporter activity

lipid transfer activity [inference]

phospholipid transfer activity [inference]

phosphatidylcholine transfer activity

intramembrane lipid carrier activity [inference]

phosphatidylcholine intramembrane carrier activity [inference]

phosphatidylcholine flippase activity

ATPase-coupled intramembrane lipid carrier activity

flippase activity [inference]

glycerophospholipid flippase activity [inference]

phosphatidylcholine flippase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

molecular carrier activity [inference]

lipid carrier activity

lipid transfer activity [inference]

phospholipid transfer activity [inference]

phosphatidylcholine transfer activity

intramembrane lipid carrier activity [inference]

phosphatidylcholine intramembrane carrier activity [inference]

phosphatidylcholine flippase activity

ATPase-coupled intramembrane lipid carrier activity

flippase activity [inference]

glycerophospholipid flippase activity [inference]

phosphatidylcholine flippase activity

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity

ABC-type xenobiotic transporter activity

ATPase-coupled intramembrane lipid carrier activity

flippase activity [inference]

glycerophospholipid flippase activity [inference]

phosphatidylcholine flippase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Transporter

Functional Category

M: Cell wall/membrane/envelope biogenesis
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
ABC-type transporter activity
ATP binding
lipid transporter activity
nucleotide binding

Displaying **all 6** entries
InterPro
AAA+ ATPase domain
ABC transporter A
ABC transporter-like, ATP-binding domain
ABC transporter-like, conserved site
ABC-2 type transporter, transmembrane domain
P-loop containing nucleoside triphosphate hydrolase

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
alveolar lamellar body membrane	PMID:11940594

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	27410	MGI:1351617
Homo sapiens	21	HGNC:33

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements