GlyCosmos Portal

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
catalytic activity	IEA
(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity	TAS
(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity	IEA
acetyl-CoA C-acetyltransferase activity	TAS
enoyl-CoA hydratase activity	EXP

GO Hierarchy

molecular function

catalytic activity

oxidoreductase activity

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity

long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity

transferase activity

acyltransferase activity [inference]

acyltransferase activity, transferring groups other than amino-acyl groups [inference]

acetyltransferase activity [inference]

C-acetyltransferase activity [inference]

acetyl-CoA C-acetyltransferase activity

C-acyltransferase activity [inference]

acetyl-CoA C-acyltransferase activity [inference]

acetyl-CoA C-acetyltransferase activity

C-acetyltransferase activity [inference]

acetyl-CoA C-acetyltransferase activity

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

thiolester hydrolase activity [inference]

acyl-CoA hydrolase activity [inference]

fatty acyl-CoA hydrolase activity [inference]

long-chain fatty acyl-CoA hydrolase activity

lyase activity [inference]

carbon-oxygen lyase activity [inference]

hydro-lyase activity [inference]

enoyl-CoA hydratase activity

3-hydroxyacyl-CoA dehydratase activity

deacylase activity [inference]

acyl-CoA hydrolase activity [inference]

fatty acyl-CoA hydrolase activity [inference]

long-chain fatty acyl-CoA hydrolase activity

binding [inference]

protein binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

NAD+ binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding [inference]

NAD+ binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding [inference]

NAD+ binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

fatty acid beta-oxidation multifunctional protein

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
I: Lipid transport and metabolism

Displaying **all 7** entries
Gene Ontology
3-hydroxyacyl-CoA dehydrogenase activity
NAD+ binding
catalytic activity
fatty acid beta-oxidation
fatty acid metabolic process
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
oxidoreductase activity

Displaying **all 8** entries
InterPro
3-hydroxyacyl-CoA dehydrogenase, C-terminal
3-hydroxyacyl-CoA dehydrogenase, NAD binding
3-hydroxyacyl-CoA dehydrogenase, conserved site
6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
ClpP/crotonase-like domain superfamily
Enoyl-CoA hydratase/isomerase, conserved site
Enoyl-CoA hydratase/isomerase
NAD(P)-binding domain superfamily

Human Protein Atlas

ENSG00000084754

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K07515

Name

enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.211]

References

8135828

Rhea

RHEA:16105

a (3S)-3-hydroxyacyl-CoA

H₂O + a (2E)-enoyl-CoA

Enzyme

4.2.1.17

PMID

RHEA:20724

a 4-saturated-(3S)-3-hydroxyacyl-CoA

H₂O + a (3E)-enoyl-CoA

Enzyme

4.2.1.17

PMID

RHEA:76647

(3S)-3-hydroxyadipyl-CoA

H₂O + (E)-2,3-didehydroadipoyl-CoA

Enzyme

4.2.1.17

PMID

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:9452	steatotic liver disease	Alliance of Genome Resources
DOID:0070619	mitochondrial trifunctional protein deficiency 1	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 79 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000488	Retinopathy
HP:0000512	Abnormal electroretinogram
HP:0000532	Abnormal chorioretinal morphology
HP:0000533	Chorioretinal atrophy
HP:0000545	Myopia
HP:0000572	Visual loss
HP:0000577	Exotropia
HP:0000580	Pigmentary retinopathy
HP:0000613	Photophobia

Displaying **all 4** entries
Disease ID	Disease Name
OMIM:609015	mitochondrial trifunctional protein deficiency 1
OMIM:609016	long chain 3-hydroxyacyl-CoA dehydrogenase deficiency
ORPHA:5	long chain 3-hydroxyacyl-CoA dehydrogenase deficiency
ORPHA:746	mitochondrial trifunctional protein deficiency

PubChem Disease

GHR Health Conditions

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001501
Gene Name: hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements