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twisted

Summary

Gene Symbol

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

31024

KEGG Gene ID

dme:Dmel_CG12311

PubChem

31024

Alliance of Genome Resources

FB:FBgn0086368

Annotation

Keyword

Developmental protein
Endoplasmic reticulum
Glycoprotein
Glycosyltransferase
Reference proteome
Repeat
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
M9PG53	Protein twisted
Q9W5D4	Dolichyl-phosphate-mannose--protein mannosyltransferase 2 Protein twisted

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein O-linked glycosylation	IEA
muscle organ development	IMP
somatic muscle development	IMP
protein O-linked glycosylation via mannose	IDA
protein O-linked glycosylation via mannose	IBA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation

protein O-linked glycosylation via mannose

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation

protein O-linked glycosylation via mannose

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation

protein O-linked glycosylation via mannose

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation

protein O-linked glycosylation via mannose

primary metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation

protein O-linked glycosylation via mannose

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation

protein O-linked glycosylation via mannose

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation

protein O-linked glycosylation via mannose

actin filament-based process [inference]

actin cytoskeleton organization [inference]

actomyosin structure organization [inference]

sarcomere organization

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization [inference]

actomyosin structure organization [inference]

sarcomere organization

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

muscle organ development

muscle structure development [inference]

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
endoplasmic reticulum	IDA
endoplasmic reticulum	IBA
endoplasmic reticulum membrane	IDA
endoplasmic reticulum membrane	IEA
membrane	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

dolichyl-phosphate-mannose-protein mannosyltransferase complex

endoplasmic reticulum protein-containing complex [inference]

dolichyl-phosphate-mannose-protein mannosyltransferase complex

intracellular protein-containing complex [inference]

mannosyltransferase complex [inference]

dolichyl-phosphate-mannose-protein mannosyltransferase complex

catalytic complex [inference]

transferase complex [inference]

mannosyltransferase complex [inference]

dolichyl-phosphate-mannose-protein mannosyltransferase complex

cellular anatomical structure [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 5** entries
GO Term	Evidence Code	PMID
mannosyltransferase activity	IEA
dolichyl-phosphate-mannose-protein mannosyltransferase activity	IDA
dolichyl-phosphate-mannose-protein mannosyltransferase activity	IMP
dolichyl-phosphate-mannose-protein mannosyltransferase activity	IEA
protein binding	IPI

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

hexosyltransferase activity [inference]

mannosyltransferase activity

dolichyl-phosphate-mannose-protein mannosyltransferase activity

catalytic activity, acting on a protein [inference]

dolichyl-phosphate-mannose-protein mannosyltransferase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Protein O-mannosyl-transferase

Functional Category

H: Coenzyme transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
dolichyl-phosphate-mannose-protein mannosyltransferase activity
mannosyltransferase activity
protein O-linked glycosylation
protein O-linked mannosylation
transferase activity

Displaying **all 5** entries
InterPro
Glycosyl transferase family 39/83
Glycosyltransferase 39-like
MIR motif
Mir domain superfamily
Protein O-mannosyl-transferase, C-terminal four TM domain

KEGG BRITE Database

Orthology

K00728

Name

dolichyl-phosphate-mannose-protein mannosyltransferase [EC:2.4.1.109]

References

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R07620	2.4.1.109	G74840NI	G61491DK

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
dolichyl-phosphate-mannose-protein mannosyltransferase complex	PMID:15271988
endoplasmic reticulum	PMID:16219785

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0112374	muscular dystrophy-dystroglycanopathy	Alliance of Genome Resources
DOID:0050560	Walker-Warburg syndrome	Alliance of Genome Resources

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP009134
Gene Name: Protein O-mannosyltransferase 2

Ortholog

Displaying **all 8** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	217734	MGI:2444430
Rattus norvegicus	688673	RGD:1586427
Homo sapiens	29954	HGNC:19743
Saccharomyces cerevisiae S288C	853113	SGD:S000003431
Saccharomyces cerevisiae S288C	854499	SGD:S000005848
Saccharomyces cerevisiae S288C	851210	SGD:S000000021
Danio rerio	563878	ZFIN:ZDB-GENE-070112-1002
Xenopus tropicalis	100490100	Xenbase:XB-GENE-1006906

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements