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leucine rich repeat containing 8 VRAC subunit A

Summary

Gene Symbol

Lrrc8a

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

311846

KEGG Gene ID

PubChem

311846

Alliance of Genome Resources

RGD:1311690

Annotation

Keyword

Acetylation
Cell membrane
Disulfide bond
Glycoprotein
Ion channel
Leucine-rich repeat
Lysosome
Phosphoprotein
Reference proteome
Repeat
Spermatogenesis
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q4V8I7	Leucine-rich repeat-containing protein 8A Swelling protein 1 SWELL1
A6JTW3	Leucine-rich repeat-containing protein 8A

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 47 in total

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GO Term	Evidence Code	PMID
intracellular glucose homeostasis	ISS
intracellular glucose homeostasis	ISO
intracellular glucose homeostasis	IEA
pre-B cell differentiation	ISS
pre-B cell differentiation	ISO

GO Hierarchy

biological process

immune system process [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

B cell differentiation [inference]

immature B cell differentiation [inference]

pre-B cell differentiation

B cell activation [inference]

B cell differentiation [inference]

immature B cell differentiation [inference]

pre-B cell differentiation

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

B cell differentiation [inference]

immature B cell differentiation [inference]

pre-B cell differentiation

B cell activation [inference]

B cell differentiation [inference]

immature B cell differentiation [inference]

pre-B cell differentiation

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

B cell differentiation [inference]

immature B cell differentiation [inference]

pre-B cell differentiation

transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport

chloride transmembrane transport

alkanesulfonate transmembrane transport [inference]

taurine transmembrane transport

purine-containing compound transmembrane transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

import across plasma membrane [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

nucleotide transmembrane transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

carboxylic acid transmembrane transport [inference]

aspartate transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein hexamerization

regulation of cellular component size [inference]

regulation of cell size [inference]

cell volume homeostasis

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein hexamerization

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

B cell differentiation [inference]

immature B cell differentiation [inference]

pre-B cell differentiation

B cell activation [inference]

B cell differentiation [inference]

immature B cell differentiation [inference]

pre-B cell differentiation

developmental process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

B cell differentiation [inference]

immature B cell differentiation [inference]

pre-B cell differentiation

homeostatic process [inference]

cellular homeostasis [inference]

cell volume homeostasis

intracellular chemical homeostasis [inference]

intracellular glucose homeostasis

chemical homeostasis [inference]

carbohydrate homeostasis [inference]

glucose homeostasis [inference]

intracellular glucose homeostasis

intracellular chemical homeostasis [inference]

intracellular glucose homeostasis

response to stimulus [inference]

response to stress [inference]

response to osmotic stress

response to abiotic stimulus [inference]

response to osmotic stress

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic anion transport

chloride transport [inference]

chloride transmembrane transport

monoatomic anion transmembrane transport

chloride transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport

chloride transmembrane transport

amino acid transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

acidic amino acid transport [inference]

aspartate transmembrane transport

inorganic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

organic anion transport

alkanesulfonate transmembrane transport [inference]

taurine transmembrane transport

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

C4-dicarboxylate transport [inference]

aspartate transmembrane transport

carboxylic acid transmembrane transport [inference]

aspartate transmembrane transport

cyclic-GMP-AMP transmembrane import across plasma membrane

organophosphate ester transport [inference]

nucleotide transport [inference]

purine nucleotide transport [inference]

guanine nucleotide transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

purine ribonucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

adenine nucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

cyclic nucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

nucleotide transmembrane transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

organic acid transport [inference]

alkanesulfonate transmembrane transport [inference]

taurine transmembrane transport

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

C4-dicarboxylate transport [inference]

aspartate transmembrane transport

carboxylic acid transmembrane transport [inference]

aspartate transmembrane transport

transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport

chloride transmembrane transport

alkanesulfonate transmembrane transport [inference]

taurine transmembrane transport

purine-containing compound transmembrane transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

import across plasma membrane [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

nucleotide transmembrane transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

carboxylic acid transmembrane transport [inference]

aspartate transmembrane transport

nitrogen compound transport [inference]

nucleobase-containing compound transport [inference]

nucleotide transport [inference]

purine nucleotide transport [inference]

guanine nucleotide transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

purine ribonucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

adenine nucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

cyclic nucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

nucleotide transmembrane transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

purine-containing compound transmembrane transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

sulfur compound transport [inference]

alkanesulfonate transmembrane transport [inference]

taurine transmembrane transport

import into cell [inference]

import across plasma membrane [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

carbohydrate derivative transport [inference]

purine ribonucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

positive regulation of signaling [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

positive regulation of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

regulation of transport [inference]

regulation of secretion [inference]

regulation of peptide secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of protein secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

regulation of peptide transport [inference]

regulation of peptide secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of cell differentiation [inference]

positive regulation of myoblast differentiation

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of myoblast differentiation

positive regulation of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of myoblast differentiation

regulation of myoblast differentiation [inference]

positive regulation of myoblast differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of myoblast differentiation

regulation of cellular process [inference]

regulation of cell communication [inference]

positive regulation of cell communication [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of myoblast differentiation

regulation of myoblast differentiation [inference]

positive regulation of myoblast differentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of cell differentiation [inference]

positive regulation of myoblast differentiation

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of protein secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

regulation of biological quality [inference]

regulation of hormone levels [inference]

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of cell size [inference]

cell volume homeostasis

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
cytoplasm	IBA
lysosomal membrane	ISS
lysosomal membrane	ISO
lysosomal membrane	IEA
plasma membrane	ISS

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex

cellular anatomical structure [inference]

membrane

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
volume-sensitive anion channel activity	ISS
volume-sensitive anion channel activity	ISO
volume-sensitive anion channel activity	IMP
volume-sensitive anion channel activity	IBA
volume-sensitive anion channel activity	IEA