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major histocompatibility complex, class II, DR beta 3

Summary

Gene Symbol

HLA-DRB3

Organism

Homo sapiens (human)

External Links

NCBI Gene

3125

PubChem

3125

Alliance of Genome Resources

HGNC:4951

JoGo

HLA-DRB3

TogoVar

HLA-DRB3

Annotation

Keyword

3D-structure
Cell membrane
Cytoplasmic vesicle
Disulfide bond
Endoplasmic reticulum
Endosome
Glycoprotein
Lysosome
MHC II
Proteomics identification
Reference proteome
Signal
Transmembrane helix
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A4D6G1L1
P79483	MHC class II antigen DRB3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
adaptive immune response
myeloid dendritic cell antigen processing and presentation	IDA
peptide antigen assembly with MHC class II protein complex	IBA
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
positive regulation of T cell mediated immune response to tumor cell	IDA

GO Hierarchy

biological process

immune system process [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

immune response

adaptive immune response

antigen processing and presentation

dendritic cell antigen processing and presentation [inference]

myeloid dendritic cell antigen processing and presentation

antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

antigen processing and presentation of peptide antigen via MHC class II [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

antigen processing and presentation of exogenous antigen [inference]

antigen processing and presentation of exogenous peptide antigen [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

antigen processing and presentation of peptide antigen [inference]

antigen processing and presentation of exogenous peptide antigen [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

antigen processing and presentation of peptide antigen via MHC class II [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

cellular process [inference]

signal transduction

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

cell surface receptor signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

peptide antigen assembly with MHC protein complex [inference]

peptide antigen assembly with MHC class II protein complex

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

peptide antigen assembly with MHC protein complex [inference]

peptide antigen assembly with MHC class II protein complex

response to stimulus [inference]

immune response

adaptive immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of immune response

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

regulation of CD4-positive, alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

positive regulation of T cell activation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

regulation of immune effector process [inference]

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of leukocyte mediated immunity [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of lymphocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

regulation of adaptive immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of immune response to tumor cell [inference]

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of immune response

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of immune response

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of cellular process [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of response to tumor cell [inference]

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of immune response

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of response to tumor cell [inference]

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of response to tumor cell [inference]

positive regulation of response to tumor cell [inference]

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of immune response to tumor cell [inference]

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of response to tumor cell [inference]

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of immune response

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

regulation of adaptive immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of immune response to tumor cell [inference]

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of immune response

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immune response to tumor cell

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell

regulation of cellular process [inference]

signal transduction

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

cell surface receptor signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

regulation of cell adhesion [inference]

regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

positive regulation of cellular process [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

regulation of CD4-positive, alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

positive regulation of T cell activation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

regulation of alpha-beta T cell activation [inference]

positive regulation of alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

regulation of CD4-positive, alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

positive regulation of T cell activation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of alpha-beta T cell activation [inference]

positive regulation of CD4-positive, alpha-beta T cell activation

Displaying entries **1 - 5** of 28 in total

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GO Term	Evidence Code	PMID
Golgi membrane	TAS
lysosomal membrane	TAS
lysosomal membrane	IDA
lysosomal membrane	IBA
lysosomal membrane	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

MHC protein complex [inference]

MHC class II protein complex

cellular anatomical structure [inference]

membrane

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

late endosome membrane

transport vesicle membrane

ER to Golgi transport vesicle membrane

coated vesicle membrane [inference]

ER to Golgi transport vesicle membrane

clathrin-coated vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

endocytic vesicle membrane

clathrin-coated endocytic vesicle membrane

trans-Golgi network membrane

bounding membrane of organelle [inference]

Golgi membrane

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

autolysosome membrane

endosome membrane

late endosome membrane

transport vesicle membrane

ER to Golgi transport vesicle membrane

coated vesicle membrane [inference]

ER to Golgi transport vesicle membrane

clathrin-coated vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

endocytic vesicle membrane

clathrin-coated endocytic vesicle membrane

side of membrane [inference]

lumenal side of membrane [inference]

lumenal side of endoplasmic reticulum membrane

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein binding	IPI
MHC class II protein complex binding	IBA
MHC class II receptor activity	NAS
peptide antigen binding	ISS
peptide antigen binding	IDA

GO Hierarchy

molecular function

binding [inference]

antigen binding [inference]

peptide antigen binding

protein binding

peptide binding [inference]

peptide antigen binding

protein-containing complex binding [inference]

MHC protein complex binding [inference]

MHC class II protein complex binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

MHC class II receptor activity

immune receptor activity [inference]

MHC class II receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

HLA class II histocompatibility antigen, DO beta chain

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
adaptive immune response
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
immune response
immune system process

Displaying **all 5** entries
InterPro
Immunoglobulin C1-set
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold
Immunoglobulin/major histocompatibility complex, conserved site

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0080822	aspirin-induced respiratory disease	Alliance of Genome Resources
DOID:12361	Graves' disease	Alliance of Genome Resources
DOID:2377	multiple sclerosis	Alliance of Genome Resources
DOID:2841	asthma	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements