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dunce

Summary

Gene Symbol

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

31309

KEGG Gene ID

[""]

PubChem

31309

Alliance of Genome Resources

FB:FBgn0000479

Annotation

Keyword

Alternative initiation
Alternative splicing
Hydrolase
Metal-binding
Proteomics identification
Reference proteome
cAMP

Proteins

Displaying **all 7** entries
UniProt	Protein Name
M9PDN2
Q9W4T4	Learning/memory process protein Protein dunce cAMP-specific phosphodiesterase, isoform I
H8F4P8
P12252	Learning/memory process protein Protein dunce cAMP-specific phosphodiesterase
Q8IRU4	Learning/memory process protein Protein dunce cAMP-specific phosphodiesterase, isoform F
E2QD73
Q9W4S9	Learning/memory process protein Protein dunce cAMP-specific phosphodiesterase, isoforms N/G

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 30 in total

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GO Term	Evidence Code	PMID
conditioned taste aversion	IMP
conditioned taste aversion	IEA
cAMP catabolic process	IEA
signal transduction	IEA
chemical synaptic transmission	IMP

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

signal transduction

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

cAMP metabolic process [inference]

cAMP catabolic process

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process [inference]

cAMP catabolic process

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

cyclic nucleotide catabolic process [inference]

cAMP catabolic process

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

cyclic nucleotide metabolic process [inference]

cyclic nucleotide catabolic process [inference]

cAMP catabolic process

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process [inference]

cAMP catabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

cAMP metabolic process [inference]

cAMP catabolic process

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

cyclic nucleotide catabolic process [inference]

cAMP catabolic process

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

cAMP metabolic process [inference]

cAMP catabolic process

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

cAMP metabolic process [inference]

cAMP catabolic process

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process [inference]

cAMP catabolic process

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

cyclic nucleotide catabolic process [inference]

cAMP catabolic process

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

cyclic nucleotide metabolic process [inference]

cyclic nucleotide catabolic process [inference]

cAMP catabolic process

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process [inference]

cAMP catabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

cAMP metabolic process [inference]

cAMP catabolic process

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

cyclic nucleotide catabolic process [inference]

cAMP catabolic process

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

cAMP metabolic process [inference]

cAMP catabolic process

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

cyclic nucleotide catabolic process [inference]

cAMP catabolic process

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

cyclic nucleotide catabolic process [inference]

cAMP catabolic process

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

cyclic nucleotide catabolic process [inference]

cAMP catabolic process

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

purine-containing compound catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

carbohydrate derivative catabolic process [inference]

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

cyclic nucleotide catabolic process [inference]

cAMP catabolic process

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

cAMP metabolic process [inference]

cAMP catabolic process

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process [inference]

cAMP catabolic process

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

cyclic nucleotide catabolic process [inference]

cAMP catabolic process

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

cyclic nucleotide metabolic process [inference]

cyclic nucleotide catabolic process [inference]

cAMP catabolic process

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process [inference]

cAMP catabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

cAMP metabolic process [inference]

cAMP catabolic process

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

cyclic nucleotide catabolic process [inference]

cAMP catabolic process

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

cAMP metabolic process [inference]

cAMP catabolic process

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process [inference]

cAMP catabolic process

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

cyclic nucleotide catabolic process [inference]

cAMP catabolic process

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

cyclic nucleotide metabolic process [inference]

cyclic nucleotide catabolic process [inference]

cAMP catabolic process

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process [inference]

cAMP catabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

cAMP metabolic process [inference]

cAMP catabolic process

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

cyclic nucleotide catabolic process [inference]

cAMP catabolic process

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

cAMP metabolic process [inference]

cAMP catabolic process

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process [inference]

cAMP catabolic process

purine-containing compound catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

carbohydrate derivative metabolic process [inference]

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

cAMP metabolic process [inference]

cAMP catabolic process

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

carbohydrate derivative catabolic process [inference]

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

cAMP catabolic process

cell growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension

reproductive process [inference]

multicellular organismal reproductive process [inference]

reproductive behavior [inference]

mating behavior

courtship behavior

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning

associative learning

nonassociative learning

memory

behavior [inference]

learning or memory [inference]

learning

associative learning

nonassociative learning

memory

feeding behavior [inference]

conditioned taste aversion

chemosensory behavior [inference]

olfactory behavior [inference]

olfactory learning

reproductive behavior [inference]

mating behavior

courtship behavior

adult behavior [inference]

behavioral response to ethanol

thermosensory behavior

growth [inference]

cell growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension

developmental growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension

developmental growth involved in morphogenesis [inference]

neuron projection extension [inference]

axon extension

rhythmic process [inference]

circadian rhythm

response to stimulus [inference]

response to abiotic stimulus [inference]

response to temperature stimulus [inference]

thermosensory behavior

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP/PKA signal transduction

regulation of intracellular signal transduction [inference]

regulation of cAMP/PKA signal transduction [inference]

negative regulation of cAMP/PKA signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP/PKA signal transduction

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP/PKA signal transduction

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP/PKA signal transduction

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP/PKA signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP/PKA signal transduction

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP/PKA signal transduction

regulation of intracellular signal transduction [inference]

regulation of cAMP/PKA signal transduction [inference]

negative regulation of cAMP/PKA signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP/PKA signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP/PKA signal transduction

regulation of cellular process [inference]

signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP/PKA signal transduction

regulation of intracellular signal transduction [inference]

regulation of cAMP/PKA signal transduction [inference]

negative regulation of cAMP/PKA signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP/PKA signal transduction

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP/PKA signal transduction

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP/PKA signal transduction

Displaying **all 3** entries
GO Term	Evidence Code	PMID
nucleus	IDA
cytosol	IDA
synapse	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytosol

cell junction [inference]

synapse

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
3',5'-cyclic-nucleotide phosphodiesterase activity	IEA
3',5'-cyclic-AMP phosphodiesterase activity	ISS
3',5'-cyclic-AMP phosphodiesterase activity	EXP
3',5'-cyclic-AMP phosphodiesterase activity	IBA
3',5'-cyclic-AMP phosphodiesterase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphoric diester hydrolase activity

cyclic-nucleotide phosphodiesterase activity [inference]

3',5'-cyclic-nucleotide phosphodiesterase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cAMP-specific 3',5'-cyclic phosphodiesterase

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
3',5'-cyclic-AMP phosphodiesterase activity
3',5'-cyclic-nucleotide phosphodiesterase activity
hydrolase activity
metal ion binding

Displaying **all 5** entries
InterPro
3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily
3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
3'5'-cyclic nucleotide phosphodiesterase, conserved site
3'5'-cyclic nucleotide phosphodiesterase
HD/PDEase domain

Alliance of Genome Resources

Expression

Displaying **all 3** entries
Location	References
membrane	FB:FBrf0231198
cytosol	PMID:28076795
nucleus	PMID:28076795

Rhea

RHEA:25277

H₂O + 3',5'-cyclic AMP

H⁺ + AMP

Enzyme

3.1.4.53

PMID

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements