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3-hydroxy-3-methylglutaryl-CoA reductase

Summary

Gene Symbol

HMGCR

Organism

Homo sapiens (human)

External Links

NCBI Gene

3156

PubChem

3156

Alliance of Genome Resources

HGNC:5006

Annotation

Keyword

3D-structure
Alternative splicing
Cholesterol biosynthesis
Disease variant
Endoplasmic reticulum
Glycoprotein
Isopeptide bond
Limb-girdle muscular dystrophy
NADP
Oxidoreductase
Peroxisome
Phosphoprotein
Reference proteome
Transmembrane helix
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
P04035

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

1

2

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Last »
GO Term	Evidence Code	PMID
cholesterol biosynthetic process	IDA	23063590
isoprenoid biosynthetic process	IBA
visual learning	IEA
coenzyme A metabolic process	IEA
sterol biosynthetic process	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

nucleoside bisphosphate metabolic process [inference]

ribonucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

purine nucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

purine nucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

organonitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

purine nucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

isoprenoid biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

cholesterol biosynthetic process

isoprenoid biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

cholesterol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process

cholesterol biosynthetic process

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

nucleoside bisphosphate metabolic process [inference]

ribonucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

purine nucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

purine nucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

nucleoside bisphosphate metabolic process [inference]

ribonucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

purine nucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

nucleoside bisphosphate metabolic process [inference]

ribonucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

purine nucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

nucleoside bisphosphate metabolic process [inference]

ribonucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

purine nucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

purine nucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

cellular biosynthetic process [inference]

isoprenoid biosynthetic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

isoprenoid biosynthetic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

nucleoside bisphosphate metabolic process [inference]

ribonucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

purine nucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

purine nucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

nucleoside bisphosphate metabolic process [inference]

ribonucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

purine nucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

cholesterol biosynthetic process

sterol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

sterol biosynthetic process

cholesterol biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

cholesterol biosynthetic process

isoprenoid biosynthetic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

isoprenoid biosynthetic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

secondary alcohol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

nucleoside bisphosphate metabolic process [inference]

ribonucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

purine nucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

cholesterol biosynthetic process

sterol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

sterol biosynthetic process

cholesterol biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

cholesterol biosynthetic process

isoprenoid biosynthetic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

isoprenoid biosynthetic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

nucleoside bisphosphate metabolic process [inference]

ribonucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

purine nucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

carbohydrate derivative metabolic process [inference]

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

nucleoside bisphosphate metabolic process [inference]

ribonucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

purine nucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

cholesterol biosynthetic process

sterol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

sterol biosynthetic process

cholesterol biosynthetic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

purine nucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

cholesterol biosynthetic process

organonitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

purine nucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

cholesterol biosynthetic process

isoprenoid biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

cholesterol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process

cholesterol biosynthetic process

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

secondary alcohol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

sterol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

sterol biosynthetic process

cholesterol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process

cholesterol biosynthetic process

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

nucleoside bisphosphate metabolic process [inference]

ribonucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

purine nucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

purine nucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

nucleoside bisphosphate metabolic process [inference]

ribonucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

purine nucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

nucleoside bisphosphate metabolic process [inference]

ribonucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

purine nucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

nucleoside bisphosphate metabolic process [inference]

ribonucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

purine nucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

purine nucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

cellular biosynthetic process [inference]

isoprenoid biosynthetic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

isoprenoid biosynthetic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

nucleoside bisphosphate metabolic process [inference]

ribonucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

purine nucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

coenzyme A metabolic process

purine nucleoside bisphosphate metabolic process [inference]

coenzyme A metabolic process

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

visual learning

behavior [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

visual learning

visual behavior [inference]

visual learning

response to stimulus [inference]

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

visual behavior [inference]

visual learning

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of ERK1 and ERK2 cascade

positive regulation of signaling [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

long-term synaptic potentiation

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of protein secretion

regulation of secretion by cell [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion

negative regulation of secretion by cell [inference]

negative regulation of protein secretion

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of protein secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion

regulation of protein transport [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion

negative regulation of protein localization [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

negative regulation of cellular process [inference]

negative regulation of secretion by cell [inference]

negative regulation of protein secretion

negative regulation of protein localization [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of protein secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion

negative regulation of multicellular organismal process [inference]

negative regulation of amyloid-beta clearance

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of ERK1 and ERK2 cascade

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of ERK1 and ERK2 cascade

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

long-term synaptic potentiation

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

negative regulation of cellular process [inference]

negative regulation of secretion by cell [inference]

negative regulation of protein secretion

negative regulation of protein localization [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion

negative regulation of protein localization [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion

regulation of secretion by cell [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion

negative regulation of secretion by cell [inference]

negative regulation of protein secretion

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of amyloid-beta clearance

regulation of amyloid-beta clearance [inference]

negative regulation of amyloid-beta clearance

regulation of biological quality [inference]

regulation of synaptic plasticity [inference]

long-term synaptic potentiation

Displaying **all 5** entries
GO Term	Evidence Code	PMID
peroxisomal membrane	IDA	17180682
peroxisomal membrane	IBA
endoplasmic reticulum	IDA	17180682
endoplasmic reticulum membrane	TAS	2991281
endoplasmic reticulum membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

bounding membrane of organelle [inference]

microbody membrane [inference]

peroxisomal membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

microbody [inference]

microbody membrane [inference]

peroxisomal membrane

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

microbody [inference]

microbody membrane [inference]

peroxisomal membrane

Displaying entries **1 - 5** of 6 in total

1

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Last »
GO Term	Evidence Code	PMID
hydroxymethylglutaryl-CoA reductase (NADPH) activity	IDA	21357570 2991281
hydroxymethylglutaryl-CoA reductase (NADPH) activity	IBA
protein binding	IPI	23169578 33961781
GTPase regulator activity	IEA
NADPH binding	IDA	10698924

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

hydroxymethylglutaryl-CoA reductase (NADPH) activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

coenzyme A binding

NADP binding [inference]

NADPH binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

coenzyme A binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

coenzyme A binding

ion binding [inference]

anion binding [inference]

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

coenzyme A binding

NADP binding [inference]

NADPH binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

coenzyme A binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

coenzyme A binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

coenzyme A binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

reductase

Functional Category

H: Coenzyme transport and metabolism
I: Lipid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 3** entries
Gene Ontology
ergosterol biosynthetic process
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
oxidoreductase activity

Displaying **all 8** entries
InterPro
Hydroxymethylglutaryl-CoA reductase, N-terminal
Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily
Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily
Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site
Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily
Hydroxymethylglutaryl-CoA reductase, class I/II
Hydroxymethylglutaryl-CoA reductase, eukaryotic/archaeal type
Sterol-sensing domain

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of **103** in total

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Species	Gene ID	Orthologous MAtrix
Anolis carolinensis	100555648	ANOCA02122
Nomascus leucogenys	100597442	NOMLE14298
Loxodonta africana	100661990	LOXAF16814
Oreochromis niloticus	100697646	ORENI11797
Cavia porcellus	100726509	CAVPO24784
Cricetulus griseus	100756363	CRIGR17422
Sarcophilus harrisii	100922433	SARHA02959
Otolemur garnettii	100965474	OTOGA15247
Pan paniscus	100990336	PANPA31744
Papio anubis	101005142	PAPAN31708

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements