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G protein-coupled receptor kinase 3

Summary

Gene Symbol

Grk3

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

320129

KEGG Gene ID

PubChem

320129

Alliance of Genome Resources

MGI:87941

Annotation

Keyword

3D-structure
ATP-binding
Cell projection
Proteomics identification
Reference proteome
Serine/threonine-protein kinase
Synapse
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q3UYH7	Beta-adrenergic receptor kinase 2
Q8BVT9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
positive regulation of protein phosphorylation	ISO
desensitization of G protein-coupled receptor signaling pathway	ISS
desensitization of G protein-coupled receptor signaling pathway	ISO
desensitization of G protein-coupled receptor signaling pathway	IMP
desensitization of G protein-coupled receptor signaling pathway	IBA

GO Hierarchy

biological process

cellular process [inference]

signal transduction

G protein-coupled receptor signaling pathway

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

inositol phosphate metabolic process

organophosphate metabolic process [inference]

inositol phosphate metabolic process

pigment metabolic process [inference]

pigment metabolic process involved in pigmentation [inference]

pigment metabolic process involved in developmental pigmentation [inference]

eye pigment metabolic process [inference]

rhodopsin metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

rhodopsin metabolic process

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

rhodopsin metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

inositol phosphate metabolic process

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization [inference]

transport [inference]

protein transport [inference]

intracellular protein transport

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

intracellular transport [inference]

intracellular protein transport

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of signal transduction [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

adaptation of signaling pathway [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of signal transduction [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

adaptation of signaling pathway [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

regulation of cellular process [inference]

signal transduction

G protein-coupled receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of signal transduction [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

adaptation of signaling pathway [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
postsynaptic density	ISO
Z disc	ISO
neuronal cell body	ISO
dendritic spine	ISO
dendritic shaft	ISO

GO Hierarchy

cellular component

cellular anatomical structure [inference]

Z disc

cell junction [inference]

synapse [inference]

glutamatergic synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

neuron spine [inference]

dendritic spine

dendritic shaft

organelle [inference]

postsynaptic specialization [inference]

postsynaptic density

dendrite terminus

cell body [inference]

neuronal cell body

neuron projection terminus [inference]

axon terminus

presynapse

axon terminus

postsynapse

dendritic spine

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
G protein-coupled receptor binding	IBA
protein kinase activity	IEA
protein serine/threonine kinase activity	IEA
G protein-coupled receptor kinase activity	ISO
G protein-coupled receptor kinase activity	IDA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity

protein serine/threonine kinase activity

G protein-coupled receptor kinase activity

beta-adrenergic receptor kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity

protein serine/threonine kinase activity

G protein-coupled receptor kinase activity

beta-adrenergic receptor kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity

protein serine/threonine kinase activity

G protein-coupled receptor kinase activity

beta-adrenergic receptor kinase activity

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

G protein-coupled receptor binding

dopamine receptor binding [inference]

D1 dopamine receptor binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

G protein-coupled receptor kinase

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
ATP binding
G protein-coupled receptor binding
desensitization of G protein-coupled receptor signaling pathway
kinase activity
nucleotide binding
phosphorylation
transferase activity

Displaying entries **1 - 10** of 11 in total

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InterPro
AGC-kinase, C-terminal
GPCR kinase
PH-like domain superfamily
Pleckstrin homology domain
Protein kinase domain
Protein kinase, ATP binding site
Protein kinase-like domain superfamily
RGS domain superfamily
RGS domain
RGS, subdomain 2

Ortholog

Displaying 1 entry
Species	Gene ID	Alliance of Genome Resources
Homo sapiens	157	HGNC:290

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements