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Chondroitin sulfate synthase

Summary

Gene Symbol

Chsy

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

32497

KEGG Gene ID

dme:Dmel_CG9220

PubChem

32497

Alliance of Genome Resources

FB:FBgn0030662

Annotation

Keyword

Glycoprotein
Glycosyltransferase
Golgi apparatus
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q7KUZ9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
chondroitin sulfate proteoglycan biosynthetic process	IMP
chondroitin sulfate proteoglycan biosynthetic process	IBA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via xylose [inference]

chondroitin sulfate proteoglycan biosynthetic process

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via xylose [inference]

chondroitin sulfate proteoglycan biosynthetic process

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via xylose [inference]

chondroitin sulfate proteoglycan biosynthetic process

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

chondroitin sulfate proteoglycan metabolic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via xylose [inference]

chondroitin sulfate proteoglycan biosynthetic process

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

primary metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

chondroitin sulfate proteoglycan metabolic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via xylose [inference]

chondroitin sulfate proteoglycan biosynthetic process

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

chondroitin sulfate proteoglycan metabolic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via xylose [inference]

chondroitin sulfate proteoglycan biosynthetic process

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via xylose [inference]

chondroitin sulfate proteoglycan biosynthetic process

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

Displaying **all 4** entries
GO Term	Evidence Code	PMID
Golgi membrane	ISS
cytoplasm	IEA
Golgi apparatus	ISS
Golgi cisterna membrane	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytoplasm

membrane [inference]

organelle membrane [inference]

Golgi cisterna membrane

bounding membrane of organelle [inference]

Golgi membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying **all 4** entries
GO Term	Evidence Code	PMID
acetylgalactosaminyltransferase activity	IEA
glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity	ISS
glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity	IBA
N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity	ISS

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

acetylgalactosaminyltransferase activity

glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity

glucuronosyltransferase activity [inference]

N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity

hexosyltransferase activity [inference]

acetylgalactosaminyltransferase activity

glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity

glucuronosyltransferase activity [inference]

N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K13499

Name

chondroitin sulfate synthase [EC:2.4.1.175 2.4.1.226]

References

Reactions

Displaying **all 4** entries
KEGG Reaction	Enzyme	Acceptor	Product
R05933	2.4.1.226	G95036CM	G91368UC
R05931	2.4.1.226	G40609EP	G09318DC
R05934	2.4.1.175	G91368UC	G66923HV
R05932	2.4.1.175	G09318DC	G95036CM

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
membrane	FB:FBrf0231198

Ortholog

Displaying **all 10** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	269941	MGI:2681120
Mus musculus	78923	MGI:1926173
Rattus norvegicus	292999	RGD:1311904
Rattus norvegicus	291577	RGD:1560819
Caenorhabditis elegans	172851	WB:WBGene00005023
Homo sapiens	22856	HGNC:17198
Homo sapiens	337876	HGNC:24293
Danio rerio	324407	ZFIN:ZDB-GENE-030131-3127
Danio rerio	368477	ZFIN:ZDB-GENE-030616-4
Xenopus tropicalis	100036707	Xenbase:XB-GENE-961883

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026