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Repository for lectin-assisted multimodality data
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MIRAGE
HRas proto-oncogene, GTPase
Summary
- Gene Symbol
-
- HRAS
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Alternative splicing
- Cell membrane
- Cytoplasm
- Direct protein sequencing
- Disease variant
- GTP-binding
- Glycoprotein
- Golgi apparatus
- Hydrolase
- Isopeptide bond
- Membrane
- Methylation
- Nucleotide-binding
- Nucleus
- Palmitate
- Prenylation
- Proto-oncogene
- Reference proteome
- S-nitrosylation
- Ubl conjugation
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| MAPK cascade | ||
| positive regulation of protein phosphorylation |
|
|
| regulation of transcription by RNA polymerase II | ||
| endocytosis | ||
| chemotaxis |
GO Hierarchy
- regulation of cell cycle
biological process
cellular process [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of phosphorus metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of signaling [inference]
regulation of localization [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of cellular process [inference]
signal transduction
regulation of cell communication [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of phosphorus metabolic process [inference]
positive regulation of cellular process [inference]
regulation of cellular localization [inference]
regulation of molecular function [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| Golgi membrane | ||
| nucleoplasm | ||
| cytoplasm | ||
| endoplasmic reticulum membrane | ||
| Golgi apparatus |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| GTPase activity | ||
| GTPase activity | ||
| GTPase activity | ||
| GTPase activity | ||
| G protein activity |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Ras
- Functional Category
-
- J: Translation, ribosomal structure and biogenesis
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| GDP binding |
| GTP binding |
| InterPro |
|---|
| P-loop containing nucleoside triphosphate hydrolase |
| Small GTP-binding protein domain |
| Small GTPase, Ras-type |
| Small GTPase |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050469 | Costello syndrome | |
| DOID:0111162 | epidermal nevus | |
| DOID:0111359 | large congenital melanocytic nevus | |
| DOID:0111530 | linear nevus sebaceous syndrome | |
| DOID:10933 | obsessive-compulsive disorder | |
| DOID:11054 | urinary bladder cancer | |
| DOID:12849 | autistic disorder | |
| DOID:1749 | squamous cell carcinoma | |
| DOID:2048 | autoimmune hepatitis | |
| DOID:2671 | transitional cell carcinoma |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000006 | Autosomal dominant inheritance |
| HP:0000028 | Cryptorchidism |
| HP:0000083 | Renal insufficiency |
| HP:0000085 | Horseshoe kidney |
| HP:0000158 | Macroglossia |
| HP:0000164 | Abnormality of the dentition |
| HP:0000179 | Thick lower lip vermilion |
| HP:0000189 | Narrow palate |
| HP:0000194 | Open mouth |
| HP:0000218 | High palate |
| Disease ID | Disease Name |
|---|---|
| ORPHA:3071 |
|
| OMIM:137550 |
|
| OMIM:218040 |
|
| ORPHA:79414 |
|
| OMIM:163200 |
|
| OMIM:188470 |
|
| ORPHA:2612 |
|
| OMIM:109800 |
|
| ORPHA:2874 |
|
| OMIM:162900 |
|
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 3265 | Xenbase:XB-GENE-479381 | ||
| 3845 | FB:FBgn0003205 | ||
| 4893 | FB:FBgn0003205 | ||
| 15461 | MOUSE57051 | ||
| 16653 | FB:FBgn0003205 | ||
| 293621 | RATNO16807 | ||
| 367858 | RATNO45425 | ||
| 466302 | PANTR01907 | ||
| 698830 | MACMU11048 | ||
| 751103 | FELCA24092 |
