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hydroxysteroid 17-beta dehydrogenase 4

Summary

Gene Symbol

HSD17B4

Aliases

17-beta-HSD IV
17-beta-hydroxysteroid dehydrogenase 4
17beta-estradiol dehydrogenase type IV
3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase
D-3-hydroxyacyl-CoA dehydratase
D-bifunctional protein, peroxisomal
DBP
MFE-2
SDR8C1
beta-hydroxyacyl dehydrogenase
beta-keto-reductase
peroxisomal multifunctional protein 2
short chain dehydrogenase/reductase family 8C, member 1

Organism

Homo sapiens (human)

External Links

NCBI Gene

3295

HGNC

5213

KEGG Gene ID

hsa:3295

PubChem

3295

Alliance of Genome Resources

HGNC:5213

JoGo

HSD17B4

TogoVar

HSD17B4

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Deafness
Direct protein sequencing
Disease variant
Fatty acid metabolism
Isomerase
Lyase
NAD
Oxidoreductase
Peroxisome
Phosphoprotein
Proteomics identification
Reference proteome

Proteins

Displaying **all 7** entries
UniProt	Protein Name
B3KSP2	D-bifunctional protein Multifunctional protein 2
B2R659	17-beta-hydroxysteroid dehydrogenase 4 D-bifunctional protein Multifunctional protein 2
A0A0S2Z4J1	17-beta-hydroxysteroid dehydrogenase 4 D-bifunctional protein Multifunctional protein 2
P51659	17-beta-hydroxysteroid dehydrogenase 4 D-bifunctional protein Multifunctional protein 2 Short chain dehydrogenase/reductase family 8C member 1
E7ET17	D-bifunctional protein Multifunctional protein 2
A0A804HK65
A0A2R8Y7L2	D-bifunctional protein Multifunctional protein 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 16 in total

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GO Term	Evidence Code	PMID
fatty acid beta-oxidation	IEA
unsaturated fatty acid biosynthetic process
androgen metabolic process	IDA
estrogen metabolic process	IDA
fatty acid beta-oxidation using acyl-CoA oxidase	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

sulfur compound metabolic process [inference]

acyl-CoA metabolic process [inference]

fatty-acyl-CoA metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

fatty-acyl-CoA metabolic process [inference]

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

fatty-acyl-CoA metabolic process [inference]

catabolic process [inference]

lipid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA oxidase

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA oxidase

biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process

fatty acid derivative biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

hormone metabolic process [inference]

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

fatty-acyl-CoA metabolic process [inference]

lipid metabolic process [inference]

fatty acid metabolic process [inference]

very long-chain fatty acid metabolic process

long-chain fatty acid metabolic process [inference]

fatty acid biosynthetic process

fatty acid catabolic process [inference]

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA oxidase

fatty acid oxidation [inference]

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA oxidase

unsaturated fatty acid metabolic process [inference]

steroid metabolic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process

fatty acid derivative biosynthetic process

lipid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA oxidase

lipid modification [inference]

lipid oxidation [inference]

fatty acid oxidation [inference]

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA oxidase

fatty acid derivative metabolic process [inference]

fatty-acyl-CoA metabolic process [inference]

fatty acid derivative biosynthetic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA oxidase

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

very long-chain fatty acid metabolic process

long-chain fatty acid metabolic process [inference]

fatty acid biosynthetic process

fatty acid catabolic process [inference]

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA oxidase

fatty acid oxidation [inference]

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA oxidase

unsaturated fatty acid metabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA oxidase

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA oxidase

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA oxidase

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

fatty-acyl-CoA metabolic process [inference]

purine-containing compound metabolic process [inference]

acyl-CoA metabolic process [inference]

fatty-acyl-CoA metabolic process [inference]

olefinic compound metabolic process [inference]

alpha-linolenic acid metabolic process

cellular developmental process [inference]

cell differentiation [inference]

osteoblast differentiation

cell development [inference]

epithelial cell development [inference]

Sertoli cell development

reproductive process [inference]

developmental process involved in reproduction [inference]

Sertoli cell development

developmental process [inference]

developmental process involved in reproduction [inference]

Sertoli cell development

anatomical structure development [inference]

cell development [inference]

epithelial cell development [inference]

Sertoli cell development

cellular developmental process [inference]

cell differentiation [inference]

osteoblast differentiation

cell development [inference]

epithelial cell development [inference]

Sertoli cell development

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
peroxisome	NAS
peroxisome	IDA
peroxisome	IBA
peroxisome	IEA
peroxisomal membrane	HDA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytosol

membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

microbody membrane [inference]

peroxisomal membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

microbody lumen [inference]

peroxisomal matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

microbody [inference]

peroxisome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

microbody [inference]

peroxisome

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity	IEA
enoyl-CoA hydratase activity	IDA
estradiol 17-beta-dehydrogenase [NAD(P)+] activity	IDA
oxidoreductase activity
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

steroid dehydrogenase activity [inference]

steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity

steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

(3R)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity

lyase activity [inference]

carbon-oxygen lyase activity [inference]

hydro-lyase activity [inference]

enoyl-CoA hydratase activity

3-hydroxyacyl-CoA dehydratase activity

(2E)-enoyl-CoA hydratase activity

3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity

isomerase activity

binding [inference]

protein binding [inference]

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000133835

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K12405

Name

(3R)-3-hydroxyacyl-CoA dehydrogenase / 3a,7a,12a-trihydroxy-5b-cholest-24-enoyl-CoA hydratase / enoyl-CoA hydratase 2 [EC:1.1.1.- 4.2.1.107 4.2.1.119]

References

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0090031	D-bifunctional protein deficiency	Alliance of Genome Resources
DOID:13366	Stiff-Person syndrome	Alliance of Genome Resources
DOID:0050857	Perrault syndrome	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 78 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000107	Renal cyst
HP:0000133	Gonadal dysgenesis
HP:0000218	High palate
HP:0000239	Large fontanelles
HP:0000256	Macrocephaly
HP:0000268	Dolichocephaly
HP:0000270	Delayed cranial suture closure
HP:0000278	Retrognathia
HP:0000286	Epicanthus

Displaying **all 2** entries
Disease ID	Disease Name
OMIM:233400	Perrault syndrome 1
OMIM:261515	d-bifunctional protein deficiency

PubChem Disease

GHR Health Conditions

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP000062
Gene Name: hydroxysteroid (17-beta) dehydrogenase 4

Ortholog

Displaying 1 entry
Species	Gene ID	Alliance of Genome Resources
Mus musculus	15488	MGI:105089

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements