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MIRAGE

heat shock protein family A (Hsp70) member 4

Summary

Gene Symbol

HSPA4

Organism

Homo sapiens (human)

External Links

NCBI Gene

3308

KEGG Gene ID

PubChem

3308

Alliance of Genome Resources

HGNC:5237

Annotation

Keyword

ATP-binding
Acetylation
Alternative splicing
Cytoplasm
Direct protein sequencing
Methylation
Phosphoprotein
Proteomics identification
Reference proteome
Stress response

Proteins

Displaying 1 entry
UniProt	Protein Name
P34932	HSP70RY Heat shock 70-related protein APG-2 Heat shock protein family H member 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein folding	IBA
response to unfolded protein	NAS
protein import into mitochondrial matrix	IDA
chaperone-mediated protein complex assembly	IDA

GO Hierarchy

biological process

cellular process [inference]

protein folding

intercellular transport [inference]

protein import into mitochondrial matrix

transmembrane transport [inference]

protein transmembrane transport [inference]

protein import into mitochondrial matrix

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

chaperone-mediated protein complex assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

chaperone-mediated protein complex assembly

response to stimulus [inference]

response to stress [inference]

response to topologically incorrect protein [inference]

response to unfolded protein

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein transport [inference]

protein transmembrane transport [inference]

protein import into mitochondrial matrix

protein localization to organelle [inference]

protein localization to mitochondrion [inference]

protein import into mitochondrial matrix

establishment of localization [inference]

transport [inference]

intercellular transport [inference]

protein import into mitochondrial matrix

protein transport [inference]

protein transmembrane transport [inference]

protein import into mitochondrial matrix

transmembrane transport [inference]

protein transmembrane transport [inference]

protein import into mitochondrial matrix

establishment of protein localization [inference]

protein transport [inference]

protein transmembrane transport [inference]

protein import into mitochondrial matrix

establishment of protein localization to organelle [inference]

protein import into mitochondrial matrix

Displaying entries **6 - 7** of 7 in total

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2
GO Term	Evidence Code	PMID
extracellular exosome	IDA
extracellular exosome	HDA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 6 in total

1

2

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GO Term	Evidence Code	PMID
adenyl-nucleotide exchange factor activity	IBA
protein binding	IPI
ATP binding	NAS
ATP binding	IEA
ATP hydrolysis activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

binding [inference]

protein binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

protein folding chaperone [inference]

ATP-dependent protein folding chaperone

molecular function regulator activity [inference]

enzyme regulator activity [inference]

nucleoside-triphosphatase regulator activity [inference]

ATPase regulator activity [inference]

adenyl-nucleotide exchange factor activity

ATP-dependent activity [inference]

ATP-dependent protein folding chaperone

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Heat shock

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ATP binding
ATP-dependent protein folding chaperone
nucleotide binding

Displaying **all 5** entries
InterPro
ATPase, nucleotide binding domain
Heat shock protein 70 family
Heat shock protein 70, conserved site
Heat shock protein 70kD, C-terminal domain superfamily
Heat shock protein 70kD, peptide-binding domain superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:12140	Chagas disease	Alliance of Genome Resources

Ortholog

Displaying 1 entry
Species	Gene ID	Alliance of Genome Resources
Drosophila melanogaster	39557	FB:FBgn0026418

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026