GlyCosmos Portal

Submissions

heat shock protein family A (Hsp70) member 9

Summary

Gene Symbol

HSPA9

Organism

Homo sapiens (human)

External Links

NCBI Gene

3313

KEGG Gene ID

[""]

PubChem

3313

Alliance of Genome Resources

HGNC:5244

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Chaperone
Coiled coil
Cytoplasm
Direct protein sequencing
Disease variant
Dwarfism
Hydrolase
Methylation
Mitochondrion
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Transit peptide

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A384P5G6	75 kDa glucose-regulated protein Heat shock 70 kDa protein 9
P38646	75 kDa glucose-regulated protein Heat shock 70 kDa protein 9 Heat shock protein family A member 9 Mortalin Peptide-binding protein 74

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 21 in total

1

2

3

4

5

Next ›

Last »
GO Term	Evidence Code	PMID
protein folding	IEA
protein export from nucleus
intracellular protein transport	NAS
inner mitochondrial membrane organization	IC
response to toxic substance	IEA

GO Hierarchy

biological process

cellular process [inference]

protein folding

protein refolding

intercellular transport [inference]

calcium import into the mitochondrion

nuclear export [inference]

protein export from nucleus

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation [inference]

erythrocyte differentiation

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

protein export from nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

protein export from nucleus

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport [inference]

calcium import into the mitochondrion

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization [inference]

mitochondrial membrane organization [inference]

inner mitochondrial membrane organization

cellular component assembly [inference]

metallo-sulfur cluster assembly [inference]

iron-sulfur cluster assembly

membrane organization [inference]

mitochondrial membrane organization [inference]

inner mitochondrial membrane organization

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation [inference]

erythrocyte differentiation

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to thyroid hormone [inference]

response to thyroxine

response to nutrient levels [inference]

response to nutrient [inference]

response to vitamin [inference]

response to folic acid

response to chemical [inference]

response to acid chemical [inference]

response to amino acid [inference]

response to thyroxine

response to nutrient [inference]

response to vitamin [inference]

response to folic acid

response to toxic substance

response to hormone [inference]

response to thyroid hormone [inference]

response to thyroxine

response to peptide [inference]

response to cytokine [inference]

response to interleukin-1 [inference]

cellular response to interleukin-1

cellular response to cytokine stimulus [inference]

cellular response to interleukin-1

response to nitrogen compound [inference]

response to folic acid

response to L-phenylalanine derivative [inference]

response to thyroxine

response to oxygen-containing compound [inference]

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein transport [inference]

intracellular protein transport

protein export from nucleus

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport [inference]

calcium import into the mitochondrion

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport [inference]

calcium import into the mitochondrion

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport [inference]

calcium import into the mitochondrion

intercellular transport [inference]

calcium import into the mitochondrion

nuclear export [inference]

protein export from nucleus

protein transport [inference]

intracellular protein transport

protein export from nucleus

intracellular transport [inference]

intracellular protein transport

protein export from nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

protein export from nucleus

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport [inference]

calcium import into the mitochondrion

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

protein export from nucleus

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport

protein export from nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

protein export from nucleus

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

protein export from nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

protein export from nucleus

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of hemopoiesis

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

negative regulation of myeloid cell differentiation [inference]

negative regulation of erythrocyte differentiation

regulation of erythrocyte differentiation

negative regulation of erythrocyte differentiation

negative regulation of hemopoiesis

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of hemopoiesis

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis

negative regulation of myeloid cell differentiation [inference]

negative regulation of erythrocyte differentiation

negative regulation of hematopoietic progenitor cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis

negative regulation of myeloid cell differentiation [inference]

negative regulation of erythrocyte differentiation

negative regulation of hematopoietic progenitor cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of multicellular organismal process [inference]

negative regulation of hemopoiesis

regulation of developmental process [inference]

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis

negative regulation of myeloid cell differentiation [inference]

negative regulation of erythrocyte differentiation

negative regulation of hematopoietic progenitor cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

negative regulation of myeloid cell differentiation [inference]

negative regulation of erythrocyte differentiation

regulation of erythrocyte differentiation

negative regulation of erythrocyte differentiation

negative regulation of hemopoiesis

regulation of hematopoietic progenitor cell differentiation [inference]

negative regulation of hematopoietic progenitor cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

regulation of hematopoietic stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

regulation of stem cell differentiation [inference]

regulation of hematopoietic stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis

negative regulation of myeloid cell differentiation [inference]

negative regulation of erythrocyte differentiation

negative regulation of hematopoietic progenitor cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

negative regulation of myeloid cell differentiation [inference]

negative regulation of erythrocyte differentiation

regulation of erythrocyte differentiation

negative regulation of erythrocyte differentiation

negative regulation of hemopoiesis

regulation of cellular process [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis

negative regulation of myeloid cell differentiation [inference]

negative regulation of erythrocyte differentiation

negative regulation of hematopoietic progenitor cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

negative regulation of myeloid cell differentiation [inference]

negative regulation of erythrocyte differentiation

regulation of erythrocyte differentiation

negative regulation of erythrocyte differentiation

negative regulation of hemopoiesis

regulation of hematopoietic progenitor cell differentiation [inference]

negative regulation of hematopoietic progenitor cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

regulation of hematopoietic stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

regulation of stem cell differentiation [inference]

regulation of hematopoietic stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis

negative regulation of myeloid cell differentiation [inference]

negative regulation of erythrocyte differentiation

negative regulation of hematopoietic progenitor cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of hemopoiesis

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

negative regulation of myeloid cell differentiation [inference]

negative regulation of erythrocyte differentiation

regulation of erythrocyte differentiation

negative regulation of erythrocyte differentiation

negative regulation of hemopoiesis

Displaying entries **1 - 5** of 21 in total

1

2

3

4

5

Next ›

Last »
GO Term	Evidence Code	PMID
SAM complex	HDA
nucleolus	IEA
cytoplasm	EXP
cytoplasm	TAS
cytoplasm	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

outer mitochondrial membrane protein complex [inference]

mitochondrial outer membrane translocase complex [inference]

SAM complex

inner mitochondrial membrane protein complex [inference]

mitochondrial protein-containing complex [inference]

outer mitochondrial membrane protein complex [inference]

mitochondrial outer membrane translocase complex [inference]

SAM complex

inner mitochondrial membrane protein complex [inference]

cellular anatomical structure [inference]

cytoplasm

nucleoid [inference]

mitochondrial nucleoid

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

mitochondrion

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

membraneless organelle [inference]

intracellular membraneless organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular membraneless organelle [inference]

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 17 in total

1

2

3

4

Next ›

Last »
GO Term	Evidence Code	PMID
RNA binding	HDA
protein binding	IPI
ATP binding	IEA
ATP hydrolysis activity	EXP
ATP hydrolysis activity	IDA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

binding [inference]

nucleic acid binding [inference]

RNA binding

protein binding

growth factor binding [inference]

fibroblast growth factor binding

enzyme binding

ubiquitin-like protein ligase binding [inference]

ubiquitin protein ligase binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

protein folding chaperone

ATP-dependent protein folding chaperone

ATP-dependent activity [inference]

ATP-dependent protein folding chaperone

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

heat shock

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 3** entries
Gene Ontology
ATP binding
ATP-dependent protein folding chaperone
nucleotide binding

Displaying **all 5** entries
InterPro
ATPase, nucleotide binding domain
Heat shock protein 70 family
Heat shock protein 70, conserved site
Heat shock protein 70kD, C-terminal domain superfamily
Heat shock protein 70kD, peptide-binding domain superfamily

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060335	autosomal dominant sideroblastic anemia 4	Alliance of Genome Resources
DOID:14330	Parkinson's disease	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements