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Guidelines

MIRAGE

amyloid beta precursor like protein 1

Summary

Gene Symbol

APLP1

Organism

Homo sapiens (human)

External Links

NCBI Gene

333

KEGG Gene ID

PubChem

333

Alliance of Genome Resources

HGNC:597

Annotation

Keyword

3D-structure
Alternative splicing
Apoptosis
Cell adhesion
Cell membrane
Copper
Cytoplasm
Disulfide bond
Endocytosis
Glycoprotein
Heparin-binding
Metal-binding
Neurodegeneration
Proteomics identification
Reference proteome
Signal
Transmembrane helix
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
P51693	Amyloid beta (A4) precursor-like protein 1 Amyloid-like protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
regulation of translation
endocytosis
apoptotic process
cell adhesion
nervous system development	TAS

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mRNA metabolic process [inference]

cytosolic mRNA polyadenylation

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mRNA metabolic process [inference]

cytosolic mRNA polyadenylation

cell death [inference]

programmed cell death [inference]

apoptotic process

vesicle-mediated transport [inference]

endocytosis

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

cellular response to oxygen-containing compound [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis

extracellular structure organization [inference]

extracellular matrix organization

external encapsulating structure organization [inference]

extracellular matrix organization

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis

anatomical structure development [inference]

system development [inference]

response to stimulus [inference]

response to chemical [inference]

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

cellular response to oxygen-containing compound [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

response to nitrogen compound [inference]

response to monoamine [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

response to catecholamine [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

response to norepinephrine [inference]

cellular response to norepinephrine stimulus

cellular response to nitrogen compound [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

response to oxygen-containing compound [inference]

response to catecholamine [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

response to norepinephrine [inference]

cellular response to norepinephrine stimulus

cellular response to oxygen-containing compound [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

cellular response to oxygen-containing compound [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis

import into cell [inference]

endocytosis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

regulation of protein metabolic process [inference]

regulation of translation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of translation

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
basement membrane	TAS
nucleoplasm
cytoplasm	IEA
Golgi apparatus	IBA
Golgi apparatus	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

plasma membrane

external encapsulating structure [inference]

extracellular matrix [inference]

basement membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

perinuclear region of cytoplasm

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
protein binding	IPI
heparin binding	IEA
alpha-2A adrenergic receptor binding	IBA
alpha-2A adrenergic receptor binding	IPI
alpha-2B adrenergic receptor binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

G protein-coupled receptor binding [inference]

adrenergic receptor binding [inference]

identical protein binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

Gene Ontology information from NCBI Gene and UniProt.

Ortholog

Displaying **all 3** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	11803	MGI:88046
Caenorhabditis elegans	180783	WB:WBGene00000149
Drosophila melanogaster	31002	FB:FBgn0000108

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026