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tenascin C

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

3371

PubChem

3371

Alliance of Genome Resources

HGNC:5318

JoGo

TNC

TogoVar

TNC

Annotation

Keyword

3D-structure
Alternative splicing
Cell adhesion
Coiled coil
Direct protein sequencing
Disease variant
Disulfide bond
EGF-like domain
Extracellular matrix
Glycoprotein
Non-syndromic deafness
Phosphoprotein
Proteoglycan
Proteomics identification
Reference proteome
Repeat
Signal

Proteins

Displaying **all 3** entries
UniProt	Protein Name
B4E1W8
P24821	Cytotactin GMEM GP 150-225 Glioma-associated-extracellular matrix antigen Hexabrachion JI Myotendinous antigen Neuronectin Tenascin-C
J3QSU6	Hexabrachion Tenascin-C

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 26 in total

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GO Term	Evidence Code	PMID
regulation of cell growth	IDA
osteoblast differentiation	HDA
morphogenesis of an epithelium	IEA
cell adhesion	TAS
negative regulation of cell adhesion

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

mesenchymal-epithelial cell signaling [inference]

mesenchymal-epithelial cell signaling involved in prostate gland development

cell adhesion

cellular developmental process [inference]

cell differentiation [inference]

osteoblast differentiation

cellular response to stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin D

cellular response to stress [inference]

neuron projection regeneration [inference]

axon regeneration [inference]

peripheral nervous system axon regeneration

cellular response to chemical stimulus [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin D

cellular response to hormone stimulus [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin D stimulus

cellular response to lipid [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin D stimulus

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to prostaglandin D stimulus

cellular response to ketone [inference]

cellular response to prostaglandin D stimulus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection regeneration [inference]

axon regeneration [inference]

peripheral nervous system axon regeneration

axon development [inference]

axon regeneration [inference]

peripheral nervous system axon regeneration

cell junction organization [inference]

synapse organization [inference]

neuromuscular junction development

reproductive process [inference]

developmental process involved in reproduction [inference]

prostate gland epithelium morphogenesis

developmental process [inference]

developmental process involved in reproduction [inference]

prostate gland epithelium morphogenesis

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

odontogenesis [inference]

odontogenesis of dentin-containing tooth

tissue morphogenesis [inference]

morphogenesis of an epithelium

prostate gland epithelium morphogenesis

anatomical structure development [inference]

regeneration [inference]

neuron projection regeneration [inference]

axon regeneration [inference]

peripheral nervous system axon regeneration

cellular developmental process [inference]

cell differentiation [inference]

osteoblast differentiation

growth [inference]

developmental growth [inference]

developmental growth involved in morphogenesis [inference]

axis elongation [inference]

branch elongation of an epithelium [inference]

bud outgrowth involved in lung branching

response to stimulus [inference]

response to stress [inference]

response to wounding

response to axon injury [inference]

axon regeneration [inference]

peripheral nervous system axon regeneration

cellular response to stress [inference]

neuron projection regeneration [inference]

axon regeneration [inference]

peripheral nervous system axon regeneration

response to external stimulus [inference]

response to mechanical stimulus

response to abiotic stimulus [inference]

response to mechanical stimulus

response to endogenous stimulus [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin D stimulus

response to prostaglandin [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin D stimulus

response to prostaglandin D [inference]

cellular response to prostaglandin D stimulus

response to growth factor [inference]

response to fibroblast growth factor

cellular response to endogenous stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin D stimulus

response to nutrient levels [inference]

response to nutrient [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin D

response to vitamin [inference]

response to vitamin D [inference]

cellular response to vitamin D

cellular response to vitamin [inference]

cellular response to vitamin D

cellular response to nutrient levels [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin D

response to chemical [inference]

response to nutrient [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin D

response to vitamin [inference]

response to vitamin D [inference]

cellular response to vitamin D

cellular response to vitamin [inference]

cellular response to vitamin D

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin D stimulus

response to prostaglandin [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin D stimulus

response to prostaglandin D [inference]

cellular response to prostaglandin D stimulus

response to lipid [inference]

response to retinoic acid [inference]

cellular response to retinoic acid

response to vitamin D [inference]

cellular response to vitamin D

response to prostaglandin [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin D stimulus

response to prostaglandin D [inference]

cellular response to prostaglandin D stimulus

cellular response to lipid [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin D stimulus

cellular response to chemical stimulus [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin D

cellular response to hormone stimulus [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin D stimulus

cellular response to lipid [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin D stimulus

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to prostaglandin D stimulus

cellular response to ketone [inference]

cellular response to prostaglandin D stimulus

response to oxygen-containing compound [inference]

response to retinoic acid [inference]

cellular response to retinoic acid

response to vitamin D [inference]

cellular response to vitamin D

response to alcohol [inference]

response to ethanol

response to prostaglandin D [inference]

cellular response to prostaglandin D stimulus

cellular response to alcohol [inference]

cellular response to prostaglandin D stimulus

response to ketone [inference]

response to prostaglandin D [inference]

cellular response to prostaglandin D stimulus

cellular response to ketone [inference]

cellular response to prostaglandin D stimulus

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to prostaglandin D stimulus

cellular response to ketone [inference]

cellular response to prostaglandin D stimulus

cellular response to stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin D

cellular response to stress [inference]

neuron projection regeneration [inference]

axon regeneration [inference]

peripheral nervous system axon regeneration

cellular response to chemical stimulus [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin D

cellular response to hormone stimulus [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin D stimulus

cellular response to lipid [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin D stimulus

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to prostaglandin D stimulus

cellular response to ketone [inference]

cellular response to prostaglandin D stimulus

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

mesenchymal-epithelial cell signaling [inference]

mesenchymal-epithelial cell signaling involved in prostate gland development

regulation of growth [inference]

regulation of cell growth

regulation of locomotion [inference]

regulation of cell motility [inference]

regulation of cell migration

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell adhesion

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

regulation of inflammatory response

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of inflammatory response

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cell adhesion

negative regulation of cell adhesion

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

negative regulation of cellular process [inference]

negative regulation of cell adhesion

regulation of cellular component organization [inference]

regulation of cell growth

regulation of cell motility [inference]

regulation of cell migration

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular region	IBA
extracellular region	IEA
extracellular region	HDA
basement membrane	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

protein complex involved in cell adhesion [inference]

protein complex involved in cell-matrix adhesion [inference]

tenascin complex

extracellular protein-containing complex [inference]

tenascin complex

cellular anatomical structure [inference]

cell junction [inference]

synapse [inference]

glutamatergic synapse

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

external encapsulating structure [inference]

extracellular matrix

specialized extracellular matrix [inference]

extracellular matrix of synaptic cleft

synapse-associated extracellular matrix [inference]

perisynaptic extracellular matrix

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
integrin binding	IDA
extracellular matrix structural constituent	RCA
extracellular matrix structural constituent	ISS
protein binding	IPI
identical protein binding	IPI

GO Hierarchy

molecular function

structural molecule activity [inference]

extracellular matrix structural constituent

binding [inference]

protein binding

signaling receptor binding [inference]

integrin binding

identical protein binding

proteoglycan binding [inference]

syndecan binding

cell adhesion molecule binding [inference]

integrin binding

protein-containing complex binding [inference]

integrin binding

carbohydrate derivative binding [inference]

proteoglycan binding [inference]

syndecan binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

tenascin

Functional Category

G: Carbohydrate transport and metabolism
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
neuron projection development
regulation of cell adhesion

Displaying **all 9** entries
InterPro
EGF-like domain, extracellular
EGF-like domain
Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
Fibrinogen-like, C-terminal
Fibronectin type III superfamily
Fibronectin type III
Immunoglobulin-like fold
Tenascin, EGF-like domain

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0110581	autosomal dominant nonsyndromic deafness 56	Alliance of Genome Resources
DOID:11204	allergic conjunctivitis	Alliance of Genome Resources
DOID:2841	asthma	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements