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Guidelines

MIRAGE

C-type lectin domain family 4 member D

Summary

Gene Symbol

CLEC4D

Organism

Homo sapiens (human)

External Links

NCBI Gene

338339

KEGG Gene ID

PubChem

338339

Alliance of Genome Resources

HGNC:14554

Annotation

Keyword

3D-structure
Adaptive immunity
Calcium
Cell membrane
Disulfide bond
Glycoprotein
Innate immunity
Lectin
Metal-binding
Proteomics identification
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8WXI8	C-type lectin superfamily member 8 C-type lectin-like receptor 6 Dendritic cell-associated C-type lectin 3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
adaptive immune response
T cell differentiation involved in immune response
positive regulation of myeloid dendritic cell activation	ISS
positive regulation of myeloid dendritic cell activation	IEA
Fc-gamma receptor signaling pathway

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell differentiation involved in immune response

immune response [inference]

adaptive immune response

innate immune response [inference]

antifungal innate immune response

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell differentiation involved in immune response

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell differentiation involved in immune response

lymphocyte differentiation [inference]

T cell differentiation [inference]

T cell differentiation involved in immune response

T cell activation [inference]

T cell activation involved in immune response [inference]

T cell differentiation involved in immune response

T cell differentiation [inference]

T cell differentiation involved in immune response

cellular process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell differentiation involved in immune response

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell differentiation involved in immune response

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell differentiation involved in immune response

lymphocyte differentiation [inference]

T cell differentiation [inference]

T cell differentiation involved in immune response

T cell activation [inference]

T cell activation involved in immune response [inference]

T cell differentiation involved in immune response

T cell differentiation [inference]

T cell differentiation involved in immune response

signal transduction [inference]

immune response-regulating signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

Fc receptor signaling pathway [inference]

Fc-gamma receptor signaling pathway

cell surface receptor signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

Fc receptor signaling pathway [inference]

Fc-gamma receptor signaling pathway

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

T cell differentiation involved in immune response

multicellular organismal process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell differentiation involved in immune response

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell differentiation involved in immune response

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell differentiation involved in immune response

lymphocyte differentiation [inference]

T cell differentiation [inference]

T cell differentiation involved in immune response

T cell activation [inference]

T cell activation involved in immune response [inference]

T cell differentiation involved in immune response

T cell differentiation [inference]

T cell differentiation involved in immune response

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

T cell differentiation involved in immune response

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

response to fungus [inference]

defense response to fungus [inference]

antifungal innate immune response

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

antifungal innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to bacterium

defense response to fungus [inference]

antifungal innate immune response

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

antifungal innate immune response

immune response [inference]

adaptive immune response

innate immune response [inference]

antifungal innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

response to fungus [inference]

defense response to fungus [inference]

antifungal innate immune response

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

antifungal innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

response to fungus [inference]

defense response to fungus [inference]

antifungal innate immune response

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

antifungal innate immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of myeloid dendritic cell activation

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of myeloid dendritic cell activation

regulation of myeloid dendritic cell activation [inference]

positive regulation of myeloid dendritic cell activation

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

Fc receptor signaling pathway [inference]

Fc-gamma receptor signaling pathway

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of myeloid dendritic cell activation

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of myeloid dendritic cell activation

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of myeloid dendritic cell activation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

Fc receptor signaling pathway [inference]

Fc-gamma receptor signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

immune response-regulating signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

Fc receptor signaling pathway [inference]

Fc-gamma receptor signaling pathway

cell surface receptor signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

Fc receptor signaling pathway [inference]

Fc-gamma receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of myeloid dendritic cell activation

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of myeloid dendritic cell activation

regulation of myeloid dendritic cell activation [inference]

positive regulation of myeloid dendritic cell activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of myeloid dendritic cell activation

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of myeloid dendritic cell activation

regulation of myeloid dendritic cell activation [inference]

positive regulation of myeloid dendritic cell activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of myeloid dendritic cell activation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of myeloid dendritic cell activation

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
plasma membrane	TAS
plasma membrane	IDA
plasma membrane	IEA
external side of plasma membrane	IBA
specific granule membrane	TAS

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane [inference]

bounding membrane of organelle [inference]

secretory granule membrane [inference]

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
protein binding	IPI
D-mannose binding	IDA
carbohydrate binding	IBA
immunoglobulin receptor binding	IEA
pattern recognition receptor activity	IDA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

immunoglobulin receptor binding

carbohydrate binding

monosaccharide binding [inference]

D-mannose binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

monosaccharide binding [inference]

D-mannose binding

molecular transducer activity [inference]

signaling receptor activity [inference]

pattern recognition receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

C-type lectin c

Functional Category

I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
glucan catabolic process

Displaying **all 2** entries
InterPro
Concanavalin A-like lectin/glucanase domain superfamily
Glycoside hydrolase family 16

Ortholog

Displaying **all 4** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	17474	MGI:1298389
Rattus norvegicus	362432	RGD:1303339
Drosophila melanogaster	35216	FB:FBgn0016675
Drosophila melanogaster	3346222	FB:FBgn0053532

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Last updated: April 6, 2026