GlyCosmos Portal

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
magnesium ion binding	IDA
magnesium ion binding	IEA
isocitrate dehydrogenase (NADP+) activity	IDA
isocitrate dehydrogenase (NADP+) activity	IBA
isocitrate dehydrogenase (NADP+) activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

isocitrate dehydrogenase [NAD(P)+] activity [inference]

isocitrate dehydrogenase (NADP+) activity

binding [inference]

protein binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

cell adhesion molecule binding [inference]

cadherin binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

magnesium ion binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

isocitrate dehydrogenase (NADP)

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis

Displaying **all 9** entries
Gene Ontology
NADP metabolic process
glyoxylate cycle
isocitrate dehydrogenase (NADP+) activity
isocitrate metabolic process
magnesium ion binding
metal ion binding
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
oxidoreductase activity
tricarboxylic acid cycle

Displaying **all 3** entries
InterPro
Isocitrate dehydrogenase NADP-dependent
Isocitrate/isopropylmalate dehydrogenase, conserved site
Isopropylmalate dehydrogenase-like domain

Human Protein Atlas

ENSG00000138413

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K00031

Name

isocitrate dehydrogenase [EC:1.1.1.42]

References

Rhea

RHEA:19629

D-threo-isocitrate + NADP⁺

CO₂ + 2-oxoglutarate + NADPH

Enzyme

1.1.1.42

PMID

Disease

Disease Ontology

Displaying **all 6** entries
DO ID	Disease Name	Source
DOID:0050908	myelodysplastic syndrome	Alliance of Genome Resources
DOID:3068	glioblastoma	Alliance of Genome Resources
DOID:3070	high grade glioma	Alliance of Genome Resources
DOID:417	autoimmune disease	Alliance of Genome Resources
DOID:5016	hepatocellular clear cell carcinoma	Alliance of Genome Resources
DOID:9119	acute myeloid leukemia	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of **101** in total

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HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0000122	Unilateral renal agenesis
HP:0000233	Thin vermilion border
HP:0000256	Macrocephaly
HP:0000278	Retrognathia
HP:0000337	Broad forehead
HP:0000343	Long philtrum
HP:0000400	Macrotia
HP:0000470	Short neck
HP:0000494	Downslanted palpebral fissures

Displaying **all 4** entries
Disease ID	Disease Name
ORPHA:296	Ollier disease
OMIM:137800	glioma susceptibility 1
ORPHA:163634	Maffucci syndrome
ORPHA:99646	metaphyseal chondromatosis with D-2-hydroxyglutaric aciduria